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公开(公告)号：US11518971B2
公开(公告)日：2022-12-06
申请号：US16695550
申请日：2019-11-26
Applicant: RESEARCH TRIANGLE INSTITUTE
Inventor： Leah Marie Johnson , Ninell Pollas Mortensen , Ginger Denison Rothrock , Nicolas D. Huffman
Abstract: A three-dimensional cell growth containment article is described, which includes a molded body channelized by removal of sacrificial channelizing element(s) therefrom, so that the molded body contains one or more channel(s) therein, with a matrix material in at least one of such channel(s) that is supportive of three-dimensional cell growth in the matrix material. A method for making such articles is also described, in which a molded body is formed with one or more sacrificial channelizing element(s) therein, following which the sacrificial channelizing element(s) are removed. The three-dimensional cell growth containment articles of the present disclosure may be utilized in any applications in which there exists a need to reproducibly generate three-dimensional cellular structures, e.g., islet transplantation for diabetes treatment, transplantation of hormone secreting cells, cellular scaffolds for wound healing, and generation of tissue engineering structures to regain structural usefulness for orthopedic applications.
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公开(公告)号：US10292909B2
公开(公告)日：2019-05-21
申请号：US15918026
申请日：2018-03-12
Inventor： Leah Marie Johnson , Ginger Denison Rothrock , Sarah Dorothy Shepherd , Sandra Cordel O'Buckley , Andrea Gail Neely
Abstract: The disclosure provides biocompatible dental material that is moldable and biodegradable and provides sustained and/or controlled delivery of one or more local anesthetics within a dental cavity or space. Such dental material is customizable for the size and shape needed for a particular patient or particular application. The dental material may also provide customizable sustained and/or controlled delivery of one or more local anesthetics.
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公开(公告)号：US09943466B1
公开(公告)日：2018-04-17
申请号：US15622238
申请日：2017-06-14
Inventor： Leah Marie Johnson , Ginger Denison Rothrock , Sarah Dorothy Shepherd , Sandra Cordel O'Buckley , Andrea Gail Neely
CPC classification number: A61K6/0067 , A61K6/0002 , A61K9/0002 , A61K9/1647 , A61K47/42 , A61K2300/00
Abstract: The disclosure provides biocompatible dental material that is moldable and biodegradable and provides sustained and/or controlled delivery of one or more local anesthetics within a dental cavity or space. Such dental material is customizable for the size and shape needed for a particular patient or particular application. The dental material may also provide customizable sustained and/or controlled delivery of one or more local anesthetics.
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公开(公告)号：US12110451B2
公开(公告)日：2024-10-08
申请号：US17355828
申请日：2021-06-23
Applicant: Research Triangle Institute
Inventor： Leah Marie Johnson , Ginger Denison Rothrock , Chasity Antoninette Norton , Nicolas Daniel Huffman , Jeffrey Brent Mecham
CPC classification number: C09K8/588 , C09K8/508 , C09K8/512 , C09K8/516 , E21B33/138 , E21B43/20 , C09K2208/10
Abstract: The present disclosure relates to delivery and release systems, such as core-shell particles. An exemplary composition according to the disclosure can include a degradable polymeric shell surrounding a core that includes a crosslinker, which can encompass a metal, such as chromium. The core-shell particles can be provided with a gel-forming polymer, such as a polyacrylamide, into a subterranean reservoir having conditions such that the shell of the core-shell polymer degrades, and the so-released metal is effective to at least partially crosslink the gel-forming polymer to form a gel. The so-formed gel can be effective to control water flow through the subterranean reservoir, such as in relation to a waterflood of the reservoir.
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公开(公告)号：US11078404B2
公开(公告)日：2021-08-03
申请号：US16547201
申请日：2019-08-21
Applicant: Research Triangle Institute
Inventor： Leah Marie Johnson , Ginger Denison Rothrock , Chasity Antoninette Norton , Nicolas Daniel Huffman , Jeffrey Brent Mecham
Abstract: The present disclosure relates to delivery and release systems, such as core-shell particles. An exemplary composition according to the disclosure can include a degradable polymeric shell surrounding a core that includes a crosslinker, which can encompass a metal, such as chromium. The core-shell particles can be provided with a gel-forming polymer, such as a polyacrylamide, into a subterranean reservoir having conditions such that the shell of the core-shell polymer degrades, and the so-released metal is effective to at least partially crosslink the gel-forming polymer to form a gel. The so-formed gel can be effective to control water flow through the subterranean reservoir, such as in relation to a waterflood of the reservoir.
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Patent Agency Ranking
公开(公告)号：US20230094662A1
公开(公告)日：2023-03-30
申请号：US18053238
申请日：2022-11-07
Applicant: RESEARCH TRIANGLE INSTITUTE
Inventor： Leah Marie Johnson , Ninell Pollas Mortensen , Ginger Denison Rothrock , Nicholas D. Huffman
Abstract: A three-dimensional cell growth containment article is described, which includes a molded body channelized by removal of sacrificial channelizing element(s) therefrom, so that the molded body contains one or more channel(s) therein, with a matrix material in at least one of such channel(s) that is supportive of three-dimensional cell growth in the matrix material. A method for making such articles is also described, in which a molded body is formed with one or more sacrificial channelizing element(s) therein, following which the sacrificial channelizing element(s) are removed. The three-dimensional cell growth containment articles of the present disclosure may be utilized in any applications in which there exists a need to reproducibly generate three-dimensional cellular structures, e.g., islet transplantation for diabetes treatment, transplantation of hormone secreting cells, cellular scaffolds for wound healing, and generation of tissue engineering structures to regain structural usefulness for orthopedic applications.
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公开(公告)号：US11147763B2
公开(公告)日：2021-10-19
申请号：US15770722
申请日：2016-10-25
Applicant: RESEARCH TRIANGLE INSTITUTE
Inventor： Leah Marie Johnson , Stephanie Lynn Swarner , Ginger Denison Rothrock , Ariane Van Der Straten Ponthoz , Brian Rhys Stoner
Abstract: The disclosure provides biomedical devices comprising indicator agents sensitive to the environment of use, methods of using same to enhance adherence to a treatment or usage regimen, and systems for monitoring compliance of use of the biomedical device. The biomedical device may be an intravaginal ring comprised of biocompatible polymeric material having indicator agent incorporated therein capable of producing a detectable change in response to a stimulus within the vaginal environment.
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公开(公告)号：US20210317360A1
公开(公告)日：2021-10-14
申请号：US17355828
申请日：2021-06-23
Applicant: Research Triangle Institute
Inventor： Leah Marie Johnson , Ginger Denison Rothrock , Chasity Antoninette Norton , Nicolas Daniel Huffman , Jeffrey Brent Mecham
Abstract: The present disclosure relates to delivery and release systems, such as core-shell particles. An exemplary composition according to the disclosure can include a degradable polymeric shell surrounding a core that includes a crosslinker, which can encompass a metal, such as chromium. The core-shell particles can be provided with a gel-forming polymer, such as a polyacrylamide, into a subterranean reservoir having conditions such that the shell of the core-shell polymer degrades, and the so-released metal is effective to at least partially crosslink the gel-forming polymer to form a gel. The so-formed gel can be effective to control water flow through the subterranean reservoir, such as in relation to a waterflood of the reservoir.
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公开(公告)号：US10421894B2
公开(公告)日：2019-09-24
申请号：US15634340
申请日：2017-06-27
Applicant: Research Triangle Institute
Inventor： Leah Marie Johnson , Ginger Denison Rothrock , Chasity Antoninette Norton , Nicolas Daniel Huffman , Jeffrey Brent Mecham
Abstract: The present disclosure relates to delivery and release systems, such as core-shell particles. An exemplary composition according to the disclosure can include a degradable polymeric shell surrounding a core that includes a crosslinker, which can encompass a metal, such as chromium. The core-shell particles can be provided with a gel-forming polymer, such as a polyacrylamide, into a subterranean reservoir having conditions such that the shell of the core-shell polymer degrades, and the so-released metal is effective to at least partially crosslink the gel-forming polymer to form a gel. The so-formed gel can be effective to control water flow through the subterranean reservoir, such as in relation to a waterflood of the reservoir.
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公开(公告)号：US20190070104A1
公开(公告)日：2019-03-07
申请号：US15770722
申请日：2016-10-25
Applicant: RESEARCH TRIANGLE INSTITUTE
Inventor： Leah Marie Johnson , Stephanie Lynn Swarner , Ginger Denison Rothrock , Ariane Van Der Straten Ponthoz , Brian Rhys Stoner
Abstract: The disclosure provides biomedical devices comprising indicator agents sensitive to the environment of use, methods of using same to enhance adherence to a treatment or usage regimen, and systems for monitoring compliance of use of the biomedical device. The biomedical device may be an intravaginal ring comprised of biocompatible polymeric material having indicator agent incorporated therein capable of producing a detectable change in response to a stimulus within the vaginal environment.
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