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公开(公告)号：US20240252530A1
公开(公告)日：2024-08-01
申请号：US17953209
申请日：2022-09-26
发明人： Geir Hermod Almås
CPC分类号： A61K33/20 , A61K9/0014 , A61K31/19 , C01B11/04
摘要： Disinfecting compositions containing hypochlorous acid and acetic acid are useful for treating transient biofilms in or on tissue without harming the natural flora of the tissue. The compositions are useful for treating a variety of types of tissue. Compositions are useful for treating and preventing orally-associated biofilm. Compositions may be provided in mouthwash form, spray form, gel form, cream form, dentifrice form, and may include nanoparticle encapsulated molecules for controlled release.
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公开(公告)号：US12036519B2
公开(公告)日：2024-07-16
申请号：US17164154
申请日：2021-02-01
IPC分类号： B01F25/10 , B01F25/00 , B01F25/452 , B01F35/71 , B01F23/451 , B01F101/00 , C02F1/68 , C02F1/76
CPC分类号： B01F25/10 , B01F25/4521 , B01F23/451 , B01F2025/911 , B01F2025/919 , B01F35/715 , B01F2101/305 , B01F2215/0431 , B01F2215/045 , B01F2215/0468 , C02F1/686 , C02F1/76 , C02F2209/005 , C02F2209/05 , C02F2209/06 , C02F2301/024
摘要： The invention generally relates to a mixing device. In certain embodiments, devices of the invention include a fluidic inlet, a fluidic outlet, and a chamber, the chamber being configured to produce a plurality of fluidic vortexes within the chamber.
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公开(公告)号：US20220387484A1
公开(公告)日：2022-12-08
申请号：US17842100
申请日：2022-06-16
发明人： Geir Hermod Almås
摘要： Disinfecting compositions containing hypochlorous acid and acetic acid are useful for treating biofilms in or on tissue, including biofilms related to wounds or other skin trauma. The compositions are useful for treating a variety of types of tissue, both on the surface on beneath the surface of tissue. Compositions are provided having various concentrations for different tissue types and infection levels. Compositions may be provided in gel form, and may include nanoparticle encapsulated molecules for controlled release.
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公开(公告)号：US20220323488A1
公开(公告)日：2022-10-13
申请号：US17838866
申请日：2022-06-13
发明人： Geir Hermod Almås
摘要： Provided are anti-microbial compositions that include an aqueous solution of hypochlorous acid encapsulated in a nanoparticle that allows for controlled release of hypochlorous acid. Also provided are methods of making and using such compositions.
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公开(公告)号：US20220008456A1
公开(公告)日：2022-01-13
申请号：US17369620
申请日：2021-07-07
摘要： The present invention provides stable antimicrobial and disinfectant compositions comprising use of a solid precursor of an oxidized state of chlorine. The invention also provides on-demand storage and mixing vessels and methods for preparing and delivering on demand formulations. In addition, the invention provides antiviral, antibiotic and general antimicrobial uses, in vivo, on surfaces and via spray applications.
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公开(公告)号：US20210371279A1
公开(公告)日：2021-12-02
申请号：US17176085
申请日：2021-02-15
发明人： Geir Hermod Almås
摘要： The invention provides a skin disinfectant for treating skin with eczema, preventing bacterial proliferation, and removing biofilm. Compositions of the invention include hypochlorous acid, acetic acid, water, and one or more additives or excipients. The formulation process removes metal ions, reduces ionic strength, controls pH, and reduces exposure to air, thus improving stability and lengthening shelf-life.
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公开(公告)号：US10675299B2
公开(公告)日：2020-06-09
申请号：US15167076
申请日：2016-05-27
发明人： Geir Hermod Almås
摘要： The invention provides a skin disinfectant for treating skin with eczema, preventing bacterial proliferation, and removing biofilm. Compositions of the invention include hypochlorous acid, acetic acid, water, and one or more additives or excipients. The formulation process removes metal ions, reduces ionic strength, controls pH, and reduces exposure to air, thus improving stability and lengthening shelf-life.
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公开(公告)号：US10577244B2
公开(公告)日：2020-03-03
申请号：US14618799
申请日：2015-02-10
发明人： Geir Hermod Almås , Adrian Bignami
摘要： The invention generally relates to compositions of hypochlorous acid (HOCl) and methods of manufacture thereof. In certain aspects, the invention provides air-free compositions of HOCl. In other aspects, the invention provides methods of making HOCl that involve mixing together in water in an air-free environment, a compound that generates a proton (H+) in water and a compound that generates a hypochlorite anion (OCl−) in water to thereby produce air-free hypochlorous acid.
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公开(公告)号：US12115185B2
公开(公告)日：2024-10-15
申请号：US14618820
申请日：2015-02-10
发明人： Geir Hermod Almås , Adrian Bignami
摘要： The invention generally relates to compositions of hypochlorous acid (HOCl) and methods of manufacture thereof. In certain aspects, the invention provides air-free compositions of HOCl. In other aspects, the invention provides methods of making HOCl that involve mixing together in water in an air-free environment, a compound that generates a proton (H+) in water and a compound that generates a hypochlorite anion (OCl−) in water to thereby produce air-free hypochlorous acid.
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公开(公告)号：US20240122971A1
公开(公告)日：2024-04-18
申请号：US18449222
申请日：2023-08-14
发明人： Geir Hermod Almås
CPC分类号： A61K33/20 , A01N25/34 , A01N59/08 , A01P1/00 , A61K9/0007 , A61K9/0078 , A61K9/2009 , A61K9/2013 , A61K9/2031 , A61P31/04
摘要： The present invention provides new storable and stable disinfectant compositions comprising use of a solid precursor of an oxidized state of chlorine. The component in the device is devoid of stability issues, since the solid precursors are instantly to be dissolved in water or a pharmaceutically acceptable diluent, adjuvant, or carrier, and combined with an activator, e.g. adipic or succinic acid or their salts, optionally combined with a viscosity enhancer, optionally combined with a dye. The main product according to the invention is generated by dissolving effervescent material in the form of tablets or granules, the resulting solutions from dissolution of the effervescent material are useful disinfectants for treating a broad spectrum of pathogenic bacterial and/or viral, fungal, or parasitic pathogens, denoted microbials.
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