公开(公告)号：US12220605B2

公开(公告)日：2025-02-11

申请号：US17454978

申请日：2021-11-15

Applicant: Rosenbauer International AG

Inventor： Roland Jungmair ,  Hannes Hammer

IPC: A62C5/00 ,  A62C5/02 ,  A62C27/00 ,  B01F25/00 ,  B01F25/312

Abstract: A method as well as a liquid mixing system for providing a liquid mixture of water with at least one additive. The liquid mixing system comprises a first water reservoir, a first additive reservoir, a mixing unit, a conveying device and a line network. At least one first measurement value of the flow of the first additive conveyed to a mixing device is determined by an additive flowmeter. The total stream of the liquid mixture conveyed by the conveying device is measured by a liquid mixture flowmeter. The determined measurement values are transmitted to a control device, and from there passed on to a data storage device where they are stored.

公开(公告)号：US12186719B2

公开(公告)日：2025-01-07

申请号：US18440659

申请日：2024-02-13

Applicant: Control Solutions, Inc.

Inventor： John Carespodi

IPC: B01F25/72 ,  B01F25/74 ,  B01F35/75 ,  B05B7/04 ,  B01F25/00

Abstract: A mixing apparatus including a mixing region can have an inlet and an outlet. The mixing region can be operable to couple with a solution housing, thereby defining a mixing chamber. A stem can extend from a surface of the mixing region and the inlet can be disposed at a distal end of the stem. A wing can disposed at a proximal end of the stem and adjacently engaged with the surface of the mixing region and have a leading edge and a trailing edge.

公开(公告)号：US12097495B2

公开(公告)日：2024-09-24

申请号：US17750195

申请日：2022-05-20

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Benjamin J. Hindson ,  Serge Saxonov ,  Phillip Belgrader ,  Kevin D. Ness ,  Michael Y. Lucero ,  Billy W. Colston, Jr. ,  Shawn Paul Hodges ,  Nicholas J. Heredia ,  Jeffrey Clark Mellen ,  Camille Bodley Troup ,  Paul Wyatt

IPC: B01L3/00 ,  B01F23/41 ,  B01F33/3011 ,  B01F33/81 ,  B01L9/00 ,  C12Q1/686 ,  B01F25/00 ,  B01F25/23 ,  B01F33/302 ,  G01N35/08

CPC classification number: B01L3/50273 ,  B01F23/41 ,  B01F33/3011 ,  B01F33/813 ,  B01L3/502 ,  B01L3/502784 ,  B01L3/52 ,  B01L9/527 ,  C12Q1/686 ,  B01F25/14 ,  B01F25/23 ,  B01F33/3021 ,  B01L3/502761 ,  B01L2200/025 ,  B01L2200/0636 ,  B01L2200/0647 ,  B01L2200/0673 ,  B01L2200/14 ,  B01L2200/16 ,  B01L2300/0609 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0829 ,  B01L2300/0861 ,  B01L2400/049 ,  G01N35/08

Abstract: The present disclosure provides methods and compositions for detecting polynucleotides in a sample and for quantifying polynucleotide load in a sample. The polynucleotides can be associated with a disease, disorder, or condition. In some applications, methylated DNA is quantified, e.g., in order to determine the load of polynucleotides in a sample. The present disclosure also provides methods and compositions for determining the load of fetal polynucleotides in a biological sample, e.g., the load of fetal polynucleotides (e.g., DNA, RNA) in maternal plasma. The present disclosure provides methods and compositions for detecting cellular processes such as cellular viability, growth rates, and infection rates. This disclosure also provides compositions and methods for detecting differences in copy number of a target polynucleotide. In some embodiments, the methods and compositions provided herein are useful for diagnosis of fetal genetic abnormalities, when the starting sample is maternal tissue (e.g., blood, plasma). The methods and materials described apply techniques for allowing detection of small, but statistically significant, differences in polynucleotide copy number.

公开(公告)号：US12078650B2

公开(公告)日：2024-09-03

申请号：US16295179

申请日：2019-03-07

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Daniel Mueller

IPC: G01N35/04 ,  G01N35/10 ,  B01D35/02 ,  B01F25/00 ,  B01L3/00 ,  B01L3/02 ,  B04B5/04 ,  B04B11/04 ,  B23P19/00 ,  B65B7/16 ,  B65B7/28 ,  G01N1/28 ,  G01N21/77 ,  G01N33/543 ,  G01N35/00 ,  G01N35/02

CPC classification number: G01N35/04 ,  G01N35/10 ,  B01D35/02 ,  B01F25/00 ,  B01L3/00 ,  B01L3/02 ,  B04B5/04 ,  B04B11/04 ,  B23P19/00 ,  B65B7/16 ,  B65B7/28 ,  G01N1/28 ,  G01N21/77 ,  G01N33/543 ,  G01N35/00 ,  G01N2035/00346 ,  G01N35/02 ,  G01N2035/0405

Abstract: A method for unsealing an opening of a laboratory sample container containing a sample is presented. The opening is sealed by a closure attached to the laboratory sample container by an adhesive. An adhesive strength of the adhesive is lowerable by treatment. The method comprises treating the adhesive such that its adhesive strength is lowered and removing the closure from the laboratory sample container.

公开(公告)号：US12005408B1

公开(公告)日：2024-06-11

申请号：US18300860

申请日：2023-04-14

Applicant: SharkNinja Operating LLC

Inventor： Nathan Louis Bollen ,  Andrew David Zdeblick ,  Jack Richardson ,  Andrew Terajewicz ,  Brandon J. Suleski

IPC: B67C11/02 ,  B01F23/451 ,  B01F25/00 ,  B01F25/31 ,  B01F25/42 ,  B01F35/75 ,  B67D3/00 ,  B01F101/14

CPC classification number: B01F25/42 ,  B01F23/451 ,  B01F25/12 ,  B01F25/31 ,  B01F35/75415 ,  B67C11/02 ,  B67D3/0012 ,  B01F2025/9321 ,  B01F2101/14

Abstract: A mixing funnel for mixing fluids is provided. In one embodiment, the mixing funnel includes a tray having a fluid inlet arranged to receive a primary fluid flow, and first and second fluid passages configured to receive primary fluid flow from the fluid inlet such that the flow is divided to flow along the first and second fluid passages. The first and second fluid passages can be arranged to direct the primary fluid flow to a mixing area. The tray can further include a fluid outlet arranged to receive the primary fluid flow from the mixing area and to deliver the fluid to a container.

公开(公告)号：US20240181407A1

公开(公告)日：2024-06-06

申请号：US18440659

申请日：2024-02-13

Applicant: Control Solutions, Inc.

Inventor： John Carespodi

IPC: B01F25/72 ,  B01F25/00 ,  B01F25/74 ,  B01F35/75 ,  B05B7/04

CPC classification number: B01F25/72 ,  B01F25/74 ,  B01F35/7543 ,  B05B7/04 ,  B01F2025/9191 ,  Y10T137/2087

Abstract: A mixing apparatus including a mixing region can have an inlet and an outlet. The mixing region can be operable to couple with a solution housing, thereby defining a mixing chamber. A stem can extend from a surface of the mixing region and the inlet can be disposed at a distal end of the stem. A wing can disposed at a proximal end of the stem and adjacently engaged with the surface of the mixing region and have a leading edge and a trailing edge.

公开(公告)号：US20240100549A1

公开(公告)日：2024-03-28

申请号：US18373820

申请日：2023-09-27

Applicant: Walbro LLC

Inventor： Bradley J. Roche ,  Eric G. Zbytowski ,  Cyrus M. Healy ,  Benjermen L. Hill ,  Elizabeth M. VanSipe

IPC: B05B7/04 ,  B01F25/00 ,  B08B3/02 ,  B08B13/00

CPC classification number: B05B7/0408 ,  B01F25/1051 ,  B08B3/026 ,  B08B13/00 ,  B01F2101/4505 ,  B08B2203/0217

Abstract: A mixing system for a power washer includes an electrically actuated valve communicated with a supply of a working fluid, and having a valve head that is movable between open and closed positions to control the flow rate of the working fluid through an outlet of the valve. The outlet of the valve is communicated with a fluid passage of the power washer to enable flow of the working fluid into a primary fluid and discharge of a mixture of the primary fluid and working fluid from the power washer when the valve is open, and to provide a flow of primary fluid from the power washer when the valve is closed.

公开(公告)号：US11845645B2

公开(公告)日：2023-12-19

申请号：US16996402

申请日：2020-08-18

Applicant: Jeffrey Russell ,  John Russell ,  Jo Ann Franklin

Inventor： Jeffrey Russell ,  John Russell ,  Jo Ann Franklin

IPC: B01F25/00 ,  B01F23/451 ,  E04H4/12 ,  B67D3/00

CPC classification number: B67D3/0016 ,  B01F23/451 ,  B01F25/1051 ,  B67D3/0003 ,  B67D3/0041 ,  B67D3/0077 ,  E04H4/1281

Abstract: A chemical mixture dispensing assembly for automatically filling a fluid containment with a predetermined ratio of chemicals and water includes a housing that is mountable on a support surface such that the housing is positioned proximate a fluid containment. The housing is fluid coupled to a water source, a first chemical source and a second chemical source. A mixing unit is positioned in the housing and the mixing unit mixes a predetermined volume of fluid from the first chemical source and the second chemical source with a predetermined volume of water from the water source to produce a fluid mixture. The mixing unit dispenses a predetermined volume of the fluid mixture from the mixture outlet to fill the fluid containment with the fluid mixture.

公开(公告)号：US11835148B2

公开(公告)日：2023-12-05

申请号：US16875490

申请日：2020-05-15

Applicant: FLOW CONTROL LLC

Inventor： Akshaykumar Patel ,  Derrick Tran

IPC: B01F23/10 ,  B01F35/221 ,  B01F25/00 ,  F16K11/00 ,  B01F23/451 ,  B01F23/232

CPC classification number: F16K19/00 ,  B01F23/191 ,  B01F23/232 ,  B01F23/451 ,  B01F25/1051 ,  B01F35/2217 ,  Y10T137/87684

Abstract: A control valve features a first housing and a second housing. The first housing includes a first inlet port having a first inlet port orifice member with a first inlet port orifice size configured to provide a first inlet fluid with a first inlet volumetric flow rate, the first inlet port orifice member being detachably coupled inside the first inlet port; includes a second inlet port having a second inlet port orifice member with a second inlet port orifice size configured to provide a second inlet fluid with a second inlet volumetric flow rate, the second inlet port orifice member being detachably coupled inside the second inlet port; and includes a first housing rim configured to extend from the first fixed inlet and the second fixed inlet. The second housing includes a second housing rim coupled to the first housing rim and configured to form a mixture chamber to mix the first inlet fluid received from the first fixed inlet orifice and the second inlet fluid received from the second fixed inlet orifice and provide a mixture chamber fluid; and an outlet port having an outlet port orifice with an outlet port orifice size configured to provide the mixture chamber fluid as an outlet port fluid having an outlet volumetric flow rate. The outlet port fluid has a mixture ratio of the first inlet fluid and the second inlet fluid for a particular application that depends on dimensions of the first inlet port orifice size, the second inlet port orifice size and the outlet port orifice size.

公开(公告)号：US11821881B2

公开(公告)日：2023-11-21

申请号：US17104874

申请日：2020-11-25

Applicant: Waters Technologies Corporation

Inventor： Timothy M. Raymond ,  Christopher Walden ,  Sean Anderson

IPC: G01N30/32 ,  B01D15/16 ,  G01N30/34 ,  G01N30/20 ,  B01F25/00 ,  G01N30/02

CPC classification number: G01N30/32 ,  B01D15/163 ,  B01D15/166 ,  B01F25/1051 ,  G01N30/20 ,  G01N30/34 ,  G01N2030/027 ,  G01N2030/205 ,  G01N2030/322 ,  G01N2030/328 ,  G01N2030/347

Abstract: Disclosed is a gradient proportioning valve for liquid chromatography that includes a plurality of inlet ports configured to receive a plurality of fluids, a manifold connected to each of the plurality of inlet ports configured to mix the plurality of fluids in a controlled manner to provide a fluid composition, the manifold including a plurality of fluid conduits internal to the manifold, each of the plurality of fluid conduits receiving fluid through a respective one of the plurality of inlet ports, each of the plurality of fluid conduits operatively communicable to a respective actuation mechanism configured to open and close each of the plurality of fluid conduits in a controlled manner, a common outlet port configured to receive the fluid composition, and a passive fluidic dampening system configured to dampen unwanted fluidic pressure pulses in the manifold where at least one of the plurality of fluid conduits is compliant.