公开(公告)号：US11969480B2

公开(公告)日：2024-04-30

申请号：US17185587

申请日：2021-02-25

申请人： Translate Bio, Inc.

发明人： Shrirang Karve ,  Ashish Sarode ,  Frank DeRosa

IPC分类号： C07H21/02 ,  A61K9/51 ,  A61K47/60 ,  A61K47/69 ,  A61K48/00 ,  B01F23/451 ,  B01F33/301 ,  B01J13/20 ,  B01F101/22

CPC分类号： A61K48/0091 ,  A61K9/5123 ,  A61K47/60 ,  A61K47/6925 ,  A61K48/0033 ,  B01F23/451 ,  B01F33/3017 ,  B01J13/203 ,  B01F2101/22

摘要： The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of mixing a suspension of preformed lipid nanoparticles and mRNA.

公开(公告)号：US11944943B2

公开(公告)日：2024-04-02

申请号：US17853149

申请日：2022-06-29

申请人： Oil & Gas Measurement Limited

发明人： Wessenu Abegaz Maru ,  John Richard Waters

IPC分类号： B01F25/00 ,  B01F23/451 ,  B01F25/313 ,  B01F25/314 ,  B01F35/22 ,  G01N1/20

CPC分类号： B01F25/31324 ,  B01F23/451 ,  B01F25/313311 ,  B01F25/31334 ,  B01F25/314 ,  B01F25/31422 ,  B01F35/2202 ,  B01F2025/913 ,  B01F2215/0409 ,  G01N2001/2064

摘要： A nozzle for injecting a first liquid mass into a stream of second liquid mass flowing within a pipe, comprising a first, outer, cylinder and second, inner, cylinder concentrically arranged about a nozzle axis, securing means for securing the nozzle to a wall of the pipe with the nozzle axis orthogonal to the pipe wall, the nozzle projecting into an interior of the pipe in use, duct means for receiving the first liquid mass and transporting it to the interior of the inner and outer cylinders, the inner cylinder comprising at least one hole arranged to expel liquid therethrough, and the outer cylinder comprising at least one hole arranged to expel liquid therethrough.

公开(公告)号：US20240066478A1

公开(公告)日：2024-02-29

申请号：US18548565

申请日：2021-03-02

申请人： CARGILL, INCORPORATED

发明人： Alan SBRAVATI ,  Ron WESTERHOUT ,  Kevin R. WIRTZ

IPC分类号： B01F23/70 ,  B01D15/18 ,  B01D15/22 ,  B01D19/00 ,  B01D36/02 ,  B01F23/40 ,  B01F23/451 ,  B01F25/00 ,  H01B3/20

CPC分类号： B01F23/708 ,  B01D15/1871 ,  B01D15/22 ,  B01D19/0036 ,  B01D36/02 ,  B01F23/451 ,  B01F23/49 ,  B01F23/703 ,  B01F23/711 ,  B01F25/1051 ,  H01B3/20

摘要： Processes for processing bio-sourced oil to produce bio-sourced oil dielectric fluids can be carried out using an apparatus mounted on a mobile transport platform system having a total footprint of no more than about 30 m2. The processes use a described array of pumps, heaters, filters, a degasser and vacuum system, and an additive metering/mixing valve system to achieve production under low energy and pressure conditions.

公开(公告)号：US20240058773A1

公开(公告)日：2024-02-22

申请号：US18260176

申请日：2021-03-25

申请人： East China University of Science and Technology

发明人： Hao LU ,  Qiang YANG ,  Yudong LI ,  Yiqian LIU ,  Pinyi DAI ,  Shihan WU

IPC分类号： B01F23/41 ,  B01F23/451 ,  B01F25/20 ,  B01F25/21 ,  B01F25/10 ,  B01F25/4314 ,  B01F25/433

CPC分类号： B01F23/4105 ,  B01F23/4143 ,  B01F23/451 ,  B01F25/28 ,  B01F25/211 ,  B01F25/103 ,  B01F25/43141 ,  B01F25/4334 ,  B01F2025/916

摘要： The invention provides a device for enhancing liquid-liquid emulsification. The device includes a jet part and a mixing part connected to the jet part. The jet part includes a feed tee for feeding major and dispersed phases, wherein the feed tee includes a first port, a second port, and a third port. The first port is used for feeding the major phase, and the second port is equipped with an ejector for feeding the dispersed phase. The ejector consists of an ejector housing and an ejector inlet section, as well as a spiral structure, a flow-guided structure, and an ejector pin structure that are connected sequentially. The mixing part includes a mixer comprising a cylindrical mixer shell, a mixer inlet section, a mixer outlet section, as well as a spiral section, a cavity section, and a variable diameter section for enhancing emulsion breakup and dispersion. A method for enhancing liquid-liquid emulsification is also disclosed. The emulsion produced by the device and method of the invention is uniformly dispersed, has long stability, and the device has a compact structure and low energy consumption. It is particularly suitable for liquid-liquid emulsification processes in fields such as chemical industry, food, coatings, and cosmetics.

公开(公告)号：US11788225B2

公开(公告)日：2023-10-17

申请号：US17157138

申请日：2021-01-25

申请人： WHIRLPOOL CORPORATION

发明人： Christopher A. Hartnett ,  James Jeffery ,  Bruno T. Ramasco ,  Guy M. Kazmierzak

IPC分类号： D06F39/02 ,  D06F21/06 ,  D06F37/26 ,  B01F23/451 ,  B01F25/452 ,  B01F25/10 ,  B01F25/421 ,  B01F101/00 ,  B01F101/48

CPC分类号： D06F39/028 ,  B01F23/451 ,  B01F25/103 ,  B01F25/4231 ,  B01F25/4521 ,  D06F37/26 ,  D06F39/022 ,  B01F2101/4505 ,  B01F2101/48 ,  D06F21/06

摘要： A chemistry dispensing assembly for a laundry appliance includes a reservoir that dispenses a laundry chemistry to a treatment chamber. A mixing channel is positioned below the reservoir that receives the laundry chemistry dispensed from the reservoir. A fluid assembly delivers a fluid carrier through a flow path that includes the mixing channel. The mixing channel is defined between an underside of the reservoir and an upper surface of the mixing channel.

公开(公告)号：US20230285312A1

公开(公告)日：2023-09-14

申请号：US18024743

申请日：2022-05-11

申请人： Inventage Lab Inc.

发明人： Euidon HAN ,  Chan Hee CHON ,  Dong Hoon KIM ,  Ju Hee KIM

IPC分类号： A61K9/51 ,  B01F33/301 ,  B01F23/41 ,  B01F23/451 ,  B01F23/40 ,  B01F23/80 ,  C12N15/88 ,  B01L3/00

CPC分类号： A61K9/5192 ,  A61K9/5123 ,  B01F23/4143 ,  B01F23/4145 ,  B01F23/451 ,  B01F23/483 ,  B01F23/49 ,  B01F23/808 ,  B01F33/3017 ,  B01L3/502753 ,  C12N15/88 ,  B01F2101/22

摘要： A lipid nanoparticles manufacturing chip includes a mixer unit for forming a mixed solution by mixing a first raw material containing an active ingredient and a second raw material containing a lipid, a dilution unit that is connected to the mixer unit and dilutes the mixed solution using a diluent solution to make a diluted mixed solution, and a concentration unit connected to the dilution unit and for obtaining a concentrated solution by concentrating lipid nanoparticles (LNP) from the diluted mixed solution.

公开(公告)号：US20240342668A1

公开(公告)日：2024-10-17

申请号：US18677069

申请日：2024-05-29

申请人： SharkNinja Operating LLC

发明人： Nathan Louis Bollen ,  Andrew David Zdeblick ,  Jack Richardson ,  Andrew Terajewicz ,  Brandon J. Suleski

IPC分类号： B01F25/42 ,  B01F23/451 ,  B01F25/00 ,  B01F25/31 ,  B01F35/75 ,  B01F101/14 ,  B67C11/02 ,  B67D3/00

CPC分类号： B01F25/42 ,  B01F23/451 ,  B01F25/12 ,  B01F25/31 ,  B01F35/75415 ,  B67C11/02 ,  B67D3/0012 ,  B01F2025/9321 ,  B01F2101/14

摘要： A mixing funnel for mixing fluids is provided. In one embodiment, the mixing funnel includes a tray having a fluid inlet arranged to receive a primary fluid flow, and first and second fluid passages configured to receive primary fluid flow from the fluid inlet such that the flow is divided to flow along the first and second fluid passages. The first and second fluid passages can be arranged to direct the primary fluid flow to a mixing area. The tray can further include a fluid outlet arranged to receive the primary fluid flow from the mixing area and to deliver the fluid to a container.

公开(公告)号：US20240315284A1

公开(公告)日：2024-09-26

申请号：US18665255

申请日：2024-05-15

申请人： Kraft Foods Group Brands LLC

发明人： Dana Marie Brown ,  Karl Ragnarsson

IPC分类号： A23L2/56 ,  A23L2/385 ,  A23L27/00 ,  B01F23/451 ,  B01F25/20 ,  B01F35/71 ,  B65D47/20

CPC分类号： A23L2/56 ,  A23L2/385 ,  A23L27/88 ,  B01F23/451 ,  B01F25/20 ,  B01F35/712 ,  B01F35/71795 ,  B65D47/2031

摘要： Concentrated liquid flavorings and methods of preparing flavored beverages using the concentrated liquid flavorings are described herein. The concentrated liquid flavorings are shelf stable for prolonged storage times at ambient temperatures. Shelf stability is provided, at least in part, by acidic pH and/or reduced water activity. By one approach, the concentrated liquid flavorings are intended to provide flavor to a beverage, such as coffee, tea, milk, or other savory beverage. The concentrated liquid flavorings may be provided in a convenient portable and dosable format that can be easily used by a consumer to provide the desired flavor and amount of flavor to a beverage.

公开(公告)号：US11957864B2

公开(公告)日：2024-04-16

申请号：US16673347

申请日：2019-11-04

申请人： B. Braun Medical Inc.

发明人： Mike Janders ,  Mariano Mumpower ,  Benjamin R. Lane

IPC分类号： A61J3/00 ,  A61M39/22 ,  A61M39/24 ,  B01F23/45 ,  B01F23/451 ,  B01F25/00 ,  B01F25/30 ,  B01F25/31 ,  B01F33/30 ,  B01F33/301 ,  B01F33/84 ,  B01F35/71 ,  B65B3/12 ,  F16K5/04 ,  F16K11/085 ,  F16K11/22 ,  F16K31/04 ,  F16K99/00 ,  B01F101/00 ,  B01F101/06 ,  B01F101/22

CPC分类号： A61M39/223 ,  A61J3/002 ,  A61M39/24 ,  B01F23/45 ,  B01F23/451 ,  B01F25/1051 ,  B01F25/30 ,  B01F25/31 ,  B01F33/30 ,  B01F33/3017 ,  B01F33/84 ,  B01F33/846 ,  B01F35/7176 ,  B01F35/717611 ,  B01F35/71805 ,  B65B3/12 ,  F16K5/04 ,  F16K5/0407 ,  F16K5/0414 ,  F16K11/085 ,  F16K11/22 ,  F16K31/041 ,  F16K99/0013 ,  F16K99/0042 ,  A61J2200/70 ,  A61M39/22 ,  A61M2039/229 ,  B01F2101/06 ,  B01F2101/22 ,  B01F2101/2202 ,  B01F2101/2204 ,  F16K11/0856 ,  F16K2099/0084

摘要： An exemplary pharmaceutical compounding system and device for mixing materials from at least two distinct material sources can include a transfer set and junction structure that has a junction body, a first inlet port located at a first portion of the junction body, a second inlet port located at a second portion of the junction body, and an outlet port located at a third portion of the junction body. The junction structure can be configured to mix fluid received from both the first inlet port and second inlet port and to deliver the fluid to the outlet port. The junction structure can also include attachment structure located on the junction body and configured to attach the junction structure to the housing of the compounding device at a location downstream of a pump system.

公开(公告)号：US20240024829A1

公开(公告)日：2024-01-25

申请号：US18221086

申请日：2023-07-12

申请人： The Trustees of Princeton University

发明人： Sujit Datta ,  Christopher Browne ,  Richard Huang ,  Callie Zheng

IPC分类号： B01F23/40 ,  C08J3/09 ,  B01J19/30 ,  B01J19/00 ,  B01F21/00 ,  B01F23/451 ,  B01F35/221 ,  B01F35/21 ,  B01F35/71 ,  G01N21/64

CPC分类号： B01F23/405 ,  C08J3/095 ,  B01J19/30 ,  B01J19/0006 ,  B01F21/02 ,  B01F23/451 ,  B01F35/2213 ,  B01F35/2217 ,  B01F35/2136 ,  B01F35/7176 ,  G01N21/6428 ,  C08J2333/26 ,  B01J2219/00162 ,  B01J2219/00164 ,  B01J2219/00234 ,  B01F2101/2805

摘要： Disclosed are techniques to mimic turbulent-enhanced reactivity under confinement by the addition of dilute high molecular weight polymers. Micro-scale imaging within a transparent porous medium reveals an elastic instability (EI), which drives chaotic fluctuations that stretch and fold solute blobs exponentially in time analogous to turbulent Batchelor mixing, despite the low Re. A reduction in the required mixing length can be observed, suggesting a cooperation between the elastic instability and the dispersion inherent to the disordered 3D porous media—which can be modeled as additive independent mixing rates, representing a dramatic conceptual simplification. The disclosed enhanced transport of solutes circumvents the traditional trade-off between throughput and reactor length, allowing a simultaneous large reduction in length and increases in throughput. Elastic flow instabilities can provide turbulent-like enhancements in chemical reaction rates, which can operate cooperatively with dispersive mixing in industrially relevant geometries.