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公开(公告)号：US09320796B2
公开(公告)日：2016-04-26
申请号：US14790113
申请日：2015-07-02
IPC分类号： A61K47/02 , A61K31/5517 , A61K9/20
CPC分类号： A61K47/02 , A61K9/2009 , A61K9/2027 , A61K9/2077 , A61K31/5517 , A61K47/32
摘要： An abuse deterrent pharmaceutical composition including a pharmaceutically active ingredient; an acid soluble ingredient; and a buffering ingredient; wherein the acid soluble ingredient and the buffering ingredient retard release of the active pharmaceutical ingredient when the composition is ingested in excess of an intended dosage.
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公开(公告)号：US20150011644A1
公开(公告)日：2015-01-08
申请号：US14322596
申请日：2014-07-02
发明人： Ronald Leech
IPC分类号： A61K31/137 , A61K47/20 , A61K47/32 , A61K47/10 , A61K47/38
CPC分类号： A61K31/137 , A61K9/2031 , A61K9/2054 , A61K47/14 , A61K47/20
摘要： A therapeutic composition comprising: a methamphetamine precursor; a gel-forming polymer; an emulsifier with a lipid backbone; a disintegrant; and a surfactant; wherein the ratio of emulsifier to gel-forming polymer on a weight basis is between about 10:1 and 1:10.
摘要翻译： 一种治疗组合物，其包含：甲基苯丙胺前体; 凝胶形成聚合物; 具有脂质主链的乳化剂; 崩解剂 和表面活性剂; 其中乳化剂与凝胶形成聚合物的重量比为约10:1至1:10。
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公开(公告)号：US11083794B2
公开(公告)日：2021-08-10
申请号：US16899529
申请日：2020-06-11
IPC分类号： A61K47/02 , A61K47/32 , A61K9/20 , A61K31/5517
摘要： An abuse deterrent pharmaceutical composition including a pharmaceutically active ingredient; an acid soluble ingredient; and a buffering ingredient; wherein the acid soluble ingredient and the buffering ingredient retard release of the active pharmaceutical ingredient when the composition is ingested in excess of an intended dosage.
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24.发明申请公开(公告)号：US20210113542A1
公开(公告)日：2021-04-22
申请号：US16498746
申请日：2018-03-30
IPC分类号： A61K31/451 , A61K47/02 , A61K47/32 , A61K47/36 , A61K47/42 , A61K47/14 , A61K47/12 , A61K47/26 , A61K47/38 , A61K47/46 , A61K45/06 , A61K31/46 , A61K31/485 , A61K31/426 , A61K9/16
摘要： An abuse deterrent pharmaceutical composition including a drug susceptible to abuse, a first acid soluble ingredient, a first buffering ingredient, and a delayed release buffering component.
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公开(公告)号：US20210077484A1
公开(公告)日：2021-03-18
申请号：US17104374
申请日：2020-11-25
发明人： Vijai KUMAR , David DIXON , Divya TEWARI , Dilip B. WADGAONKAR
摘要： This invention relates a therapeutic pharmaceutical composition comprising: a mixture including an opioid; polyethylene oxide in an amount of about 3 to about 40 wt % of the composition; a disintegrant; and a surfactant; wherein the disintegrant is present in an amount sufficient to cause the pharmaceutical composition to exhibit an immediate release profile.
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公开(公告)号：US10441657B2
公开(公告)日：2019-10-15
申请号：US15588982
申请日：2017-05-08
IPC分类号： A61K47/02 , A61K31/5517 , A61K47/32 , A61K9/20
摘要： An abuse deterrent pharmaceutical composition including a pharmaceutically active ingredient; an acid soluble ingredient; and a buffering ingredient; wherein the acid soluble ingredient and the buffering ingredient retard release of the active pharmaceutical ingredient when the composition is ingested in excess of an intended dosage.
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公开(公告)号：US20180028527A1
公开(公告)日：2018-02-01
申请号：US15725738
申请日：2017-10-05
发明人： Vijai KUMAR , David DIXON , Divya TEWARI , Dilip B. WADGAONKAR
CPC分类号： A61K31/485 , A61K9/2009 , A61K9/2013 , A61K9/2027 , A61K9/2031 , A61K9/2059 , A61K9/2095 , A61K9/2853 , A61K9/2866 , A61K9/2893 , A61K47/32 , A61K47/34 , A61K47/38
摘要： This invention relates a therapeutic pharmaceutical composition comprising: a mixture including an opioid; polyethylene oxide in an amount of about 3 to about 40 wt % of the composition; a disintegrant; and a surfactant; wherein the disintegrant is present in an amount sufficient to cause the pharmaceutical composition to exhibit an immediate release profile.
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公开(公告)号：US09757466B2
公开(公告)日：2017-09-12
申请号：US14552067
申请日：2014-11-24
IPC分类号： A61K31/5517 , A61K31/137 , A61K31/4458 , A61K31/485 , A61P25/30 , A61P25/04 , A61K47/38 , A61K9/16 , A61K9/20 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/32
CPC分类号： A61K47/38 , A61K9/1635 , A61K9/1652 , A61K9/2009 , A61K9/2013 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/2059 , A61K9/2072 , A61K31/137 , A61K31/4458 , A61K31/485 , A61K31/5517 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/32
摘要： Effective methods and compositions to deter abuse of pharmaceutical products (e.g., orally administered pharmaceutical products) including but not limited to immediate release, sustained or extended release and delayed release formulations for drugs subject to abuse comprising at least 10% by weight hydroxypropylcellulose; polyethylene oxide; and a disintegrant selected from the group consisting of crospovidone, sodium starch glycolate and croscarmellose sodium; wherein the ratio of hydroxypropylcellulose to polyethylene oxide on a weight basis is between about 10:1 and 1:10.
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29.发明申请公开(公告)号：US20170112825A1
公开(公告)日：2017-04-27
申请号：US15331643
申请日：2016-10-21
发明人： Robert Barnett JONES
IPC分类号： A61K31/485 , A61K47/48 , A61K9/00
CPC分类号： A61K31/485 , A61K9/0053 , A61K45/06 , A61K47/54 , A61K47/542
摘要： An abuse deterrent pharmaceutical composition including an abuse deterrent pharmaceutical composition including a prodrug of a pharmaceutically active ingredient and an enzyme inhibitor, wherein the enzyme inhibitor retards conversion of the prodrug to the pharmaceutically active ingredient when the composition is ingested in excess of an intended dosage.
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30.发明申请公开(公告)号：US20150374821A1
公开(公告)日：2015-12-31
申请号：US14790113
申请日：2015-07-02
IPC分类号： A61K47/02
CPC分类号： A61K47/02 , A61K9/2009 , A61K9/2027 , A61K9/2077 , A61K31/5517 , A61K47/32
摘要： An abuse deterrent pharmaceutical composition including a pharmaceutically active ingredient; an acid soluble ingredient; and a buffering ingredient; wherein the acid soluble ingredient and the buffering ingredient retard release of the active pharmaceutical ingredient when the composition is ingested in excess of an intended dosage.
摘要翻译： 包含药物活性成分的滥用威慑药物组合物; 酸溶性成分; 和缓冲成分; 其中当组合物摄取超过预期剂量时，酸溶性成分和缓冲成分阻止活性药物成分的释放。
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