公开(公告)号：US07041371B2

公开(公告)日：2006-05-09

申请号：US10810305

申请日：2004-03-26

申请人： Atsuhiko Ogura ,  Eui-chul Kang ,  Kazunori Kataoka ,  Yukio Nagasaki

发明人： Atsuhiko Ogura ,  Eui-chul Kang ,  Kazunori Kataoka ,  Yukio Nagasaki

IPC分类号： B32B5/16

CPC分类号： C30B7/14 ,  C30B7/00 ,  C30B29/48 ,  C30B29/605 ,  Y10T428/2991 ,  Y10T428/2998

摘要： This invention provides PEG-modified semiconductor nanoparticles of which fluorescence intensity is effectively inhibited from lowering, which are capable of forming a stable dispersion in water, and which are capable of bonding easily with biomolecules having specific recognition, as well as methods for conveniently preparing such nanoparticles, and a material for biological diagnosis. The water-soluble PEG-modified semiconductor nanoparticles of the present invention includes a structure having PEG of a number average molecular weight of 300 to 20000 having a thiol group at one end, bonded via cadmium to II–VI semiconductor nanocrystals of a core-shell structure having a ZnX (wherein X stands for O, S, Se, or Te) shell.

摘要翻译： 本发明提供了PEG修饰的半导体纳米粒子，其荧光强度被有效地抑制，能够在水中形成稳定的分散体，并且能够容易地与具有特定识别性的生物分子结合，以及方便地制备 纳米颗粒和用于生物诊断的材料。 本发明的水溶性PEG改性的半导体纳米粒子包括数均分子量为300〜20000的具有一端具有硫醇基的PEG的结构，其通过镉键合到芯壳的II-VI半导体纳米晶体 具有ZnX（其中X代表O，S，Se或Te）壳的结构。

公开(公告)号：US06673361B1

公开(公告)日：2004-01-06

申请号：US09980719

申请日：2001-11-15

申请人： Atsuhiko Ogura ,  Hiroshi Iwasaki ,  Shinji Tanaka

发明人： Atsuhiko Ogura ,  Hiroshi Iwasaki ,  Shinji Tanaka

IPC分类号： A61F200

CPC分类号： C08G69/44 ,  A61L17/10 ,  A61L27/14 ,  A61L27/16 ,  A61L31/048 ,  C08G65/33396 ,  C08L71/02 ,  C08L53/02 ,  C08L2666/26

摘要： A polymer having a satisfactory balance between in vivo degradability and satisfactory mechanical properties, which is an A1BA2 type polymer comprising a segment A1 and a segment A2 each having a modified amino acid and a segment B consisting of polyethylene glycol with a number-average molecular weight of 8000 or higher bonded at one end to the segment A1 and at the other end to the segment A2, and has a number-average molecular weight of 10000 to 600000; an in vivo degradable material which comprises the polymer; and a film for preventing tissue adhesion, an artificial dura mater, a suture, an implant preparation, or a sustained-release drug base each comprising the degradable material.

摘要翻译： 具有体内降解性和令人满意的机械性能之间的良好平衡的聚合物，其是包含分段A 1和段A 2的A 1 BA 2型聚合物，其各自具有修饰的氨基酸和 由数均分子量为8000以上的聚乙二醇构成的片段B的一端与片段A 1结合，另一端与片段A 2结合，数均分子量为 10000〜600000; 包含聚合物的体内可降解材料; 以及用于防止组织粘连的膜，人造硬膜，缝合线，植入物制剂或缓释药物基底，每个包含可降解材料。