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    Polyethylene glycol-modified semiconductor nanoparticles, method for producing the same, and material for biological diagnosis
    1.
    发明授权
    Polyethylene glycol-modified semiconductor nanoparticles, method for producing the same, and material for biological diagnosis 有权
    聚乙二醇改性半导体纳米粒子，其制造方法以及生物诊断用材料

    公开(公告)号：US07041371B2

    公开(公告)日：2006-05-09

    申请号：US10810305

    申请日：2004-03-26

    申请人： Atsuhiko Ogura ,  Eui-chul Kang ,  Kazunori Kataoka ,  Yukio Nagasaki

    发明人： Atsuhiko Ogura ,  Eui-chul Kang ,  Kazunori Kataoka ,  Yukio Nagasaki

    IPC分类号： B32B5/16

    CPC分类号： C30B7/14 ,  C30B7/00 ,  C30B29/48 ,  C30B29/605 ,  Y10T428/2991 ,  Y10T428/2998

    摘要： This invention provides PEG-modified semiconductor nanoparticles of which fluorescence intensity is effectively inhibited from lowering, which are capable of forming a stable dispersion in water, and which are capable of bonding easily with biomolecules having specific recognition, as well as methods for conveniently preparing such nanoparticles, and a material for biological diagnosis. The water-soluble PEG-modified semiconductor nanoparticles of the present invention includes a structure having PEG of a number average molecular weight of 300 to 20000 having a thiol group at one end, bonded via cadmium to II–VI semiconductor nanocrystals of a core-shell structure having a ZnX (wherein X stands for O, S, Se, or Te) shell.

    摘要翻译： 本发明提供了PEG修饰的半导体纳米粒子，其荧光强度被有效地抑制，能够在水中形成稳定的分散体，并且能够容易地与具有特定识别性的生物分子结合，以及方便地制备 纳米颗粒和用于生物诊断的材料。 本发明的水溶性PEG改性的半导体纳米粒子包括数均分子量为300〜20000的具有一端具有硫醇基的PEG的结构，其通过镉键合到芯壳的II-VI半导体纳米晶体 具有ZnX（其中X代表O，S，Se或Te）壳的结构。

    Method of high-speed detection for biological analyte
    4.
    发明申请
    Method of high-speed detection for biological analyte 失效
    生物分析物高速检测方法

    公开(公告)号：US20070059843A1

    公开(公告)日：2007-03-15

    申请号：US10575551

    申请日：2004-09-06

    申请人： Yukio Nagasaki ,  Kazunori Kataoka ,  Takehiko Ishii ,  Tadahito Takahashi

    发明人： Yukio Nagasaki ,  Kazunori Kataoka ,  Takehiko Ishii ,  Tadahito Takahashi

    IPC分类号： G01N33/543

    CPC分类号： G01N33/54393 ,  G01N33/5432

    摘要： This invention provides a method to detect analyte which comprises preparing fine particles which have a chargeable group in their core and a hydrophilic polymer chain in their shell; obtaining an agglutinated matter by forming a biologically specific bond between a specific residue on the surface of fine particles and analyte, and by simultaneously forming a bond by the electrostatic interaction between impure protein and said particles; and subsequently cleaving only the latter bond by raising ionic intensity. Thus, this invention provides a method to detect analyte with rapidity and high sensitivity with use of agglutination reaction.

    摘要翻译： 本发明提供一种检测分析物的方法，其包括制备在其核心中具有可带电基团的微粒和在其壳中的亲水性聚合物链; 通过在细颗粒和分析物的表面上的特定残基之间形成生物特异性键，并通过不纯蛋白与所述颗粒之间的静电相互作用同时形成粘结来获得凝集物; 并且随后通过提高离子强度来仅切割后一种键。 因此，本发明提供了使用凝集反应以快速且高灵敏度检测分析物的方法。

    Latex polymer particles containing fluorescent substance or contrast medium and process for producing the same
    9.
    发明授权
    Latex polymer particles containing fluorescent substance or contrast medium and process for producing the same 失效
    含有荧光物质或造影剂的胶乳聚合物颗粒及其制备方法

    公开(公告)号：US07470763B2

    公开(公告)日：2008-12-30

    申请号：US10539746

    申请日：2003-12-19

    申请人： Naoya Shibata ,  Yukio Nagasaki ,  Kazunori Kataoka

    发明人： Naoya Shibata ,  Yukio Nagasaki ,  Kazunori Kataoka

    IPC分类号： C08F12/04

    CPC分类号： C08F290/06 ,  A61K49/0414 ,  C08F2/44 ,  C08F290/00 ,  C08F290/02 ,  C08F290/062

    摘要： This invention provides a method to effectively incorporate inorganic fluorescent substance or inorganic contrast medium into latex polymer particles which are used for diagnostic test or the like, and also provides thus produced fluorescent substance-containing latex polymer particles which show decreased non-specific adsorption of protein or the like. Said latex polymer particles are produced by making latex-forming monomer, macromer which has at least a hydrophilic polymer segment and an inorganic fluorescent substance or an inorganic contrast medium co-existent simultaneously in an aqueous medium, and subjecting them to a polymerization reaction.

    摘要翻译： 本发明提供了一种将无机荧光物质或无机造影剂有效地并入用于诊断试验等的胶乳聚合物颗粒中的方法，并且还提供了由此产生的荧光物质的胶乳聚合物颗粒，其表现出降低的非特异性吸附蛋白质 或类似物。 所述胶乳聚合物颗粒通过制备胶乳形成单体，至少具有亲水性聚合物链段的大分子单体和无机荧光物质或无机造影剂同时存在于水性介质中并使其进行聚合反应而制备。