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    3-phenylisoquinol-1(2H)-one derivatives their preparation and their therapeutic application
    24.
    发明授权
    3-phenylisoquinol-1(2H)-one derivatives their preparation and their therapeutic application 失效
    3-苯基异喹啉-1（2H） - 酮衍生物的制备及其治疗应用

    公开(公告)号：US5665733A

    公开(公告)日：1997-09-09

    申请号：US579677

    申请日：1995-12-28

    申请人： Mireille Sevrin ,  Benoit Marabout ,  Jacques Froissant ,  Catherine Guinot

    发明人： Mireille Sevrin ,  Benoit Marabout ,  Jacques Froissant ,  Catherine Guinot

    IPC分类号： A61K31/47 ,  A61K31/472 ,  A61P25/04 ,  A61P25/28 ,  A61P27/16 ,  A61P43/00 ,  C07D217/24

    CPC分类号： C07D217/24

    摘要： A compound of formula (I) ##STR1## in which X represents a hydrogen atom, a halogen atom, a trifluoromethyl group, a C.sub.1 -C.sub.3 alkyl group or a C.sub.1 -C.sub.3 alkoxy group in which case two such alkoxy groups X can be present,Y represents a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.3 alkyl group or a C.sub.1 -C.sub.3 alkoxy group,R.sub.1 represents C.sub.1 -C.sub.4 alkyl group, andR represents a hydroxyl group, a methoxy group, an ethoxy group or a group of formula NR.sub.2 R.sub.3 in which R.sub.2 and R.sub.3 each independently represents a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group, or a pharmaceutically acceptable addition salt thereof, processes for their preparation and their therapeutic application.

    摘要翻译： 式（I）化合物其中X表示氢原子，卤素原子，三氟甲基，C1-C3烷基或C1-C3烷氧基，其中两个这样的烷氧基X 可以存在，Y表示氢原子，卤素原子，C1-C3烷基或C1-C3烷氧基，R1表示C1-C4烷基，R表示羟基，甲氧基，乙氧基 或其中R 2和R 3各自独立地表示氢原子或C 1 -C 4烷基的式NR 2 R 3基团或其药学上可接受的加成盐的方法及其治疗应用。

    N-[PHENYL(PIPERIDIN-2-YL)METHYL]BENZAMIDE DERIVATIVES, PREPARATION THEREOF, AND USE THEREOF IN THERAPY
    29.
    发明申请
    N-[PHENYL(PIPERIDIN-2-YL)METHYL]BENZAMIDE DERIVATIVES, PREPARATION THEREOF, AND USE THEREOF IN THERAPY 失效
    N- [苯基（哌啶-2-基）甲基]苯甲酰胺衍生物，其制备方法及其在治疗中的应用

    公开(公告)号：US20070155789A1

    公开(公告)日：2007-07-05

    申请号：US11680782

    申请日：2007-03-01

    申请人： Gihad DARGAZANLI ,  Genevieve ESTENNE-BOUHTOU ,  Benoit MARABOUT ,  Pierre ROGER ,  Mireille SEVRIN

    发明人： Gihad DARGAZANLI ,  Genevieve ESTENNE-BOUHTOU ,  Benoit MARABOUT ,  Pierre ROGER ,  Mireille SEVRIN

    IPC分类号： A61K31/445

    CPC分类号： C07D211/26

    摘要： This invention discloses and claims a compound of general formula (I) in which R1 represents either a hydrogen atom, or an optionally substituted alkyl group, or a cycloalkylalkyl group, or an optionally substituted phenylalkyl group, or an alkenyl group, X represents a hydrogen atom or one or more substituents chosen from halogen atoms and trifluoromethyl, alkyl and alkoxy groups, R2 represents one or more substituents chosen from halogen atoms, optionally substituted alkoxy and optionally substituted amino. The compounds of this invention exhibit therapeutic utility.

    摘要翻译： 本发明公开并要求其中R 1表示氢原子或任选取代的烷基或环烷基烷基或任选取代的苯基烷基的通式（I）的化合物，或 烯基，X表示氢原子或一个或多个选自卤素原子和三氟甲基，烷基和烷氧基的取代基，R 2表示一个或多个选自卤素原子，任选取代的烷氧基和任选取代的烷氧基的取代基 取代氨基。 本发明的化合物表现出治疗效用。