公开(公告)号：US20060056017A1

公开(公告)日：2006-03-16

申请号：US10539519

申请日：2003-12-12

Applicant: Frederic Berier ,  Bertrand Viellerobe ,  Magalie Genet ,  Francois Lacombe ,  Pedro Santos

Inventor： Frederic Berier ,  Bertrand Viellerobe ,  Magalie Genet ,  Francois Lacombe ,  Pedro Santos

IPC: G02B21/00

CPC classification number: G02B21/0072 ,  A61B1/0008 ,  A61B1/00172 ,  G02B21/0028 ,  G02B23/2407 ,  G02B26/0875 ,  G02B26/101

Abstract: An optical head includes: a point source producing an excitation beam, optical elements adapted to converge the optical beam into an excitation point located in a subsurface plane relative to the surface of a sample, the plane being perpendicular to the optical axis of the optical head; and elements for scanning the excitation point so as to define an observation field in the subsurface plane along two perpendicular scanning directions, a rapid online scanning and a slow columnar scanning. The invention includes micro-electrical mechanical systems designed to move in translation along a selected displacement at least one of the optical elements, which is mobile along a direction perpendicular to the optical axis so as to obtain at least one of the scanning directions. The invention provides the advantages of maintaining an axial illumination of the sample and of using a miniature head.

公开(公告)号：US20050242298A1

公开(公告)日：2005-11-03

申请号：US10521607

申请日：2003-07-11

Applicant: Magalie Genet ,  Bertrand Viellerobe ,  Frederic Berier ,  Sophie Clade

Inventor： Magalie Genet ,  Bertrand Viellerobe ,  Frederic Berier ,  Sophie Clade

IPC: G01N21/64 ,  A61B1/00 ,  A61B1/04 ,  A61B5/00 ,  G02B21/00 ,  G02B23/24 ,  G02B23/26 ,  G02B26/10 ,  H04N1/028

CPC classification number: H04N1/0281 ,  A61B5/0062 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0073 ,  A61B5/0084 ,  G02B21/0028 ,  G02B21/0032 ,  G02B21/0048 ,  G02B21/0072 ,  G02B21/0076 ,  G02B21/0084 ,  G02B23/26 ,  G02B26/101

Abstract: A method using an image guide having several thousands of optical fibers, an excitation signal emitted by a source, deflected and injected by turns into the optical fibers, each excitation point of the tissue in the fiber output emitting in return a fluorescence signal collected by the fiber, then detected and digitized to form an image element. The method provides for the focussing of the beam in the fiber output to excite a subsurface plane to produce a confocal image, and the production of a divergent beam in the fiber output capable of exciting a micro-volume of the tissue from the surface. The method consists in deflecting the excitation signal at a speed corresponding to acquisition of a number of images per second sufficient for real time use and in detecting the fluorescence signal at a detecting frequency corresponding to a minimum frequency for sampling the fibers one by one.

Abstract translation: 使用具有数千光纤的图像引导器的方法，由源发射的激发信号，被偏转并被轮流注入光纤中，光纤输出中的组织的每个激发点发射，以返回由 光纤，然后检测并数字化以形成图像元素。 该方法提供了光束在光纤输出中的聚焦以激发地下平面以产生共聚焦图像，并且在光纤输出中产生能够从表面激发组织的微量的发散光束。 该方法包括使激发信号以对应于获得足够实时使用的每秒数量的图像的速度偏转，以及在对应于最小频率的检测频率检测荧光信号，逐个采样光纤。

公开(公告)号：US20050078924A1

公开(公告)日：2005-04-14

申请号：US10500160

申请日：2002-12-20

Applicant: Bertrand Viellerobe ,  Magalie Genet ,  Frederic Berrier ,  Francois Lacombe ,  Aymeric Perchant ,  Georges Le Goualher ,  Sandra Marti ,  Stephane Bourriaux

Inventor： Bertrand Viellerobe ,  Magalie Genet ,  Frederic Berrier ,  Francois Lacombe ,  Aymeric Perchant ,  Georges Le Goualher ,  Sandra Marti ,  Stephane Bourriaux

IPC: G02B23/26 ,  A61B1/00 ,  A61B1/04 ,  A61B1/07 ,  G02B21/00 ,  G02B23/24 ,  G02B6/06

CPC classification number: A61B1/00188 ,  A61B1/00165 ,  A61B1/042 ,  A61B1/07 ,  A61B2562/0242 ,  G02B23/2469

Abstract: The invention concerns an equipment comprising an image guide (1) consisting of flexible optical fibers with: on the proximal end side: a source (2), angular scanning means (3), injection means (4) in one of the fibers, means for splitting (5) the illuminating beam and the backscattered signal, means for spatial filtering (6), means for detecting (7) said signal, electronic means (8) for controlling, analyzing and digital processing of the detected signal and display; and on the distal end side: an optical head (9) for focusing the illuminating beam exiting from the illuminated fiber. The invention is characterized in that the means (3) comprise a resonant line mirror (M1) and a galvanometric field mirror (M2) with a variable frequency and two afocal optical systems adapted to conjugate the two mirrors (M1, M2) firstly in the field mirror (M2) and the injection means (4) in the image guide in a second step.

Abstract translation: 本发明涉及一种包括由柔性光纤组成的图像引导件（1）的设备，其具有：在基端侧：源（2），角扫描装置（3），其中一个光纤中的注射装置（4） 用于分离（5）照明光束和反向散射信号，用于空间滤波的装置（6），用于检测（7）所述信号的装置，用于控制，分析和数字处理检测到的信号和显示的电子装置（8） 并且在远端侧：用于聚焦从照明光纤出射的照明光束的光学头（9）。 本发明的特征在于，装置（3）包括谐振线路反射镜（M1）和具有可变频率和两个无焦光学系统的电流计镜（M2），其适于首先在两个反射镜（M1，M2）中共轭 场镜（M2）和注射装置（4）在第二步骤中。