公开(公告)号：US20090215764A1

公开(公告)日：2009-08-27

申请号：US11913380

申请日：2006-05-03

Applicant: Biswajit Das ,  Jasbir Singh Arora ,  Shahadat Ahmed ,  Anish Bandyopadhyay ,  Rita Katoch ,  Santosh Haribhau Kurhade ,  Sujata Rathy ,  Soma Ghosh ,  Abhijit Datta Khoje ,  Arti Gujrati ,  Dilip J. Upadhyay

Inventor： Biswajit Das ,  Jasbir Singh Arora ,  Shahadat Ahmed ,  Anish Bandyopadhyay ,  Rita Katoch ,  Santosh Haribhau Kurhade ,  Sujata Rathy ,  Soma Ghosh ,  Abhijit Datta Khoje ,  Arti Gujrati ,  Dilip J. Upadhyay

IPC: A61K31/535 ,  C07D217/00 ,  A61K31/47 ,  C07D211/00 ,  A61K31/445 ,  C07D265/30 ,  C07D401/02 ,  A61K31/4545

CPC classification number: C07D209/48 ,  C07D213/81 ,  C07D213/82 ,  C07D231/20 ,  C07D239/42 ,  C07D249/12 ,  C07D277/36 ,  C07D295/096 ,  C07D307/68 ,  C07D333/34 ,  C07D333/38 ,  C07D333/62 ,  C07D409/04 ,  C07D409/12 ,  C07D413/04 ,  C07D513/04

Abstract: Provided herein are substituted aromatic compounds, which are tRNA synthetase inhibitors, and hence can be used as antimicrobial agents. Compounds described herein can be used for the treatment or prevention of a condition caused by or contributed to by gram positive, gram negative, anaerobic bacteria or fungal organisms, more particularly against bacterium, for example, Staphylococci, Enterococci, Streptococci, Haemophilus, Moraxalla, Escherichia, Chlamydia, Mycoplasm, Legionella, Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus or Enterobactericeae, and fungal organisms, for example, Aspergillus, Blastomyces, Candida, Coccidiodes, Cryptococcus, Epidermophyton, Hendersonula, Histoplasma, Microsporum, Paecilomyces, Paracoccidiodes, Pneumocystis, Trichophyton, or Trichosporium. Processes for the preparation of these compounds, pharmaceutical compositions thereof, and methods of treating microbial infections are also provided.

Abstract translation: 本文提供的是取代的芳族化合物，其是tRNA合成酶抑制剂，因此可以用作抗微生物剂。 本文所述的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性，厌氧菌或真菌生物引起或促成的病症，特别是针对细菌，例如葡萄球菌，肠球菌，链球菌，嗜血杆菌，莫萨拉， 大肠杆菌属，衣原体属，支原体属，军团菌属，分枝杆菌属，幽门螺杆菌属，梭菌属，拟杆菌属，棒状杆菌属，芽孢杆菌属或肠杆菌属，以及真菌生物体，例如曲霉属，布氏酵母属，假丝酵母​​属，椰子球菌属，隐球菌属，表皮生长素，亨氏嗜血菌属，组织胞浆菌属，微孢子虫属，拟青霉菌属， ，肺孢子虫（Pneumocystis），毛癣菌（Trichophyton）或三孢子虫（Trichosporium）。 还提供了制备这些化合物的方法，其药物组合物和治疗微生物感染的方法。

公开(公告)号：US08084101B2

公开(公告)日：2011-12-27

申请号：US11888476

申请日：2007-08-01

Applicant: Biswajit Das

Inventor： Biswajit Das

IPC: B05D1/40 ,  B05D3/14

CPC classification number: B82B3/00 ,  B82Y30/00 ,  B82Y40/00 ,  Y10T428/25

Abstract: Methods, apparatus and systems form structures from nanoparticles by: providing a source of nanoparticles, the particles being capable of being moved by application of a field, such as an electrical field, magnetic field and even electromagnetic radiation or fields such as light, UV, IR, radiowaves, radiation and the like; depositing the nanoparticles to a surface in a first distribution of the nanoparticles; applying a field to the nanoparticles on the surface that applies a force to the particles; and rearranging the nanoparticles on the surface by the force from the field to form a second distribution of nanoparticles on the surface. The second distribution of nanoparticles is more ordered or more patterned than the first distribution of nanoparticles as a result of the rearranging.

Abstract translation: 方法，装置和系统通过以下方式形成纳米颗粒的结构：提供纳米颗粒源，所述颗粒能够通过施加场，例如电场，磁场，甚至电磁辐射或诸如光，UV， 红外线，无线电波，辐射等; 将纳米颗粒沉积在纳米颗粒的第一分布中的表面上; 将场施加到对颗粒施加力的表面上的纳米颗粒; 并且通过来自场的力将表面上的纳米颗粒重新排列以在表面上形成纳米颗粒的第二分布。 由于重新排列，纳米颗粒的第二分布比纳米颗粒的第一分布更有序或更加图案化。

公开(公告)号：US08076370B2

公开(公告)日：2011-12-13

申请号：US11913380

申请日：2006-05-03

Applicant: Biswajit Das ,  Jasbir Singh Arora ,  Shahadat Ahmed ,  Anish Bandyopadhyay ,  Rita Katoch ,  Santosh Haribhau Kurhade ,  Sujata Rathy ,  Soma Ghosh ,  Abhijit Datta Khoje ,  Arti Gujrati ,  Dilip J. Upadhyay

Inventor： Biswajit Das ,  Jasbir Singh Arora ,  Shahadat Ahmed ,  Anish Bandyopadhyay ,  Rita Katoch ,  Santosh Haribhau Kurhade ,  Sujata Rathy ,  Soma Ghosh ,  Abhijit Datta Khoje ,  Arti Gujrati ,  Dilip J. Upadhyay

IPC: A61K31/27 ,  A61K31/18 ,  A61K31/155 ,  A61K31/44 ,  A61K31/501 ,  C07D213/72 ,  C07C333/00 ,  C07C303/00 ,  C07C277/00

CPC classification number: C07D209/48 ,  C07D213/81 ,  C07D213/82 ,  C07D231/20 ,  C07D239/42 ,  C07D249/12 ,  C07D277/36 ,  C07D295/096 ,  C07D307/68 ,  C07D333/34 ,  C07D333/38 ,  C07D333/62 ,  C07D409/04 ,  C07D409/12 ,  C07D413/04 ,  C07D513/04

Abstract: Provided herein are substituted aromatic compounds, which are tRNA synthetase inhibitors, and hence can be used as antimicrobial agents. Compounds described herein can be used for the treatment or prevention of a condition caused by or contributed to by gram positive, gram negative, anaerobic bacteria or fungal organisms, more particularly against bacterium, for example, Staphylococci, Enterococci, Streptococci, Haemophilus, Moraxalla, Escherichia, Chlamydia, Mycoplasm, Legionella, Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus or Enterobactericeae, and fungal organisms, for example, Aspergillus, Blastomyces, Candida, Coccidiodes, Cryptococcus, Epidermophyton, Hendersonula, Histoplasma, Microsporum, Paecilomyces, Paracoccidiodes, Pneumocystis, Trichophyton, or Trichosporium. Processes for the preparation of these compounds, pharmaceutical compositions thereof, and methods of treating microbial infections are also provided.

Abstract translation: 本文提供的是取代的芳族化合物，其是tRNA合成酶抑制剂，因此可以用作抗微生物剂。 本文所述的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性，厌氧菌或真菌生物引起或促成的病症，特别是针对细菌，例如葡萄球菌，肠球菌，链球菌，嗜血杆菌，莫萨拉， 大肠杆菌属，衣原体属，支原体属，军团菌属，分枝杆菌属，幽门螺杆菌属，梭菌属，拟杆菌属，棒状杆菌属，芽孢杆菌属或肠杆菌属，以及真菌生物体，例如曲霉属，布氏酵母属，假丝酵母​​属，椰子球菌属，隐球菌属，表皮生长素，亨氏嗜血菌属，组织胞浆菌属，微孢子虫属，拟青霉菌属， ，肺孢子虫（Pneumocystis），毛癣菌（Trichophyton）或三孢子虫（Trichosporium）。 还提供了制备这些化合物的方法，其药物组合物和治疗微生物感染的方法。

公开(公告)号：US20100286211A1

公开(公告)日：2010-11-11

申请号：US11576635

申请日：2005-10-06

Applicant: Biswajit Das ,  Shahadal Ahmed ,  Ajay Singh Yadav ,  Soma Ghosh ,  Arti Gujrati ,  Pankaj Sharma ,  Ashok Rattan

Inventor： Biswajit Das ,  Shahadal Ahmed ,  Ajay Singh Yadav ,  Soma Ghosh ,  Arti Gujrati ,  Pankaj Sharma ,  Ashok Rattan

IPC: A61K31/4439 ,  A61K31/433 ,  A61K31/421 ,  C07D417/14 ,  A61K31/4245 ,  C07D263/20 ,  C07D413/14 ,  A61K31/422 ,  A61P31/04

CPC classification number: C07D263/22 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention relates to certain substituted phenyl oxazolidinones and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria, for example, multiple-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms, for example, Bacterioides spp. and Clostridia spp. species, and acid fast organisms, for example, Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.

Abstract translation: 本发明涉及某些取代的苯基恶唑烷酮及其合成方法。 本发明还涉及含有作为抗微生物剂的本发明化合物的药物组合物。 这些化合物是有用的抗微生物剂，对许多人和兽医病原体有效，包括革兰氏阳性好氧细菌，例如多重耐药葡萄球菌，链球菌和肠球菌，以及厌氧生物，例如细菌属。 和梭菌属（Clostridia spp。） 物种和酸性快速生物，例如结核分枝杆菌，鸟分枝杆菌和分枝杆菌属。

公开(公告)号：US20050209248A1

公开(公告)日：2005-09-22

申请号：US10514074

申请日：2003-05-15

Applicant: Biswajit Das ,  Anita Mehta ,  Ashok Rattan

Inventor： Biswajit Das ,  Anita Mehta ,  Ashok Rattan

IPC: A61K31/496 ,  A61P31/00 ,  A61P31/04 ,  C07D413/12 ,  C07D413/14

CPC classification number: C07D413/12

Abstract: The invention relates to phenyl oxazolidinone derivatives. More particularly, it relates to polymorphic forms of (S)-N-[[3-fluoro-4-[N-1[4-{2-furyl-(5-nitro)methyl}]piperazinyl]-phenyl]-2-oxo-5-oxazolidinyl]-methyl]acetamide hydrochloride having the Formula I. Further, the invention relates to methods of using such compounds as antimicrobials, pharmaceutical compositions containing the novel polymorphic forms, and processes for the preparation of the polymorphic forms.

Abstract translation: 本发明涉及苯基恶唑烷酮衍生物。 更具体地说，它涉及（S）-N - [[3-氟-4- [N-1 [4- {2-呋喃基 - （5-硝基）甲基}]哌嗪基] - 苯基] -2 - 氧代-5-恶唑烷基]甲基]乙酰胺盐酸盐。此外，本发明涉及使用这些化合物作为抗微生物剂的方法，含有新型多晶型物的药物组合物，以及制备多晶型物的方法。