公开(公告)号：US20090215764A1

公开(公告)日：2009-08-27

申请号：US11913380

申请日：2006-05-03

申请人： Biswajit Das ,  Jasbir Singh Arora ,  Shahadat Ahmed ,  Anish Bandyopadhyay ,  Rita Katoch ,  Santosh Haribhau Kurhade ,  Sujata Rathy ,  Soma Ghosh ,  Abhijit Datta Khoje ,  Arti Gujrati ,  Dilip J. Upadhyay

发明人： Biswajit Das ,  Jasbir Singh Arora ,  Shahadat Ahmed ,  Anish Bandyopadhyay ,  Rita Katoch ,  Santosh Haribhau Kurhade ,  Sujata Rathy ,  Soma Ghosh ,  Abhijit Datta Khoje ,  Arti Gujrati ,  Dilip J. Upadhyay

IPC分类号： A61K31/535 ,  C07D217/00 ,  A61K31/47 ,  C07D211/00 ,  A61K31/445 ,  C07D265/30 ,  C07D401/02 ,  A61K31/4545

CPC分类号： C07D209/48 ,  C07D213/81 ,  C07D213/82 ,  C07D231/20 ,  C07D239/42 ,  C07D249/12 ,  C07D277/36 ,  C07D295/096 ,  C07D307/68 ,  C07D333/34 ,  C07D333/38 ,  C07D333/62 ,  C07D409/04 ,  C07D409/12 ,  C07D413/04 ,  C07D513/04

摘要： Provided herein are substituted aromatic compounds, which are tRNA synthetase inhibitors, and hence can be used as antimicrobial agents. Compounds described herein can be used for the treatment or prevention of a condition caused by or contributed to by gram positive, gram negative, anaerobic bacteria or fungal organisms, more particularly against bacterium, for example, Staphylococci, Enterococci, Streptococci, Haemophilus, Moraxalla, Escherichia, Chlamydia, Mycoplasm, Legionella, Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus or Enterobactericeae, and fungal organisms, for example, Aspergillus, Blastomyces, Candida, Coccidiodes, Cryptococcus, Epidermophyton, Hendersonula, Histoplasma, Microsporum, Paecilomyces, Paracoccidiodes, Pneumocystis, Trichophyton, or Trichosporium. Processes for the preparation of these compounds, pharmaceutical compositions thereof, and methods of treating microbial infections are also provided.

摘要翻译： 本文提供的是取代的芳族化合物，其是tRNA合成酶抑制剂，因此可以用作抗微生物剂。 本文所述的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性，厌氧菌或真菌生物引起或促成的病症，特别是针对细菌，例如葡萄球菌，肠球菌，链球菌，嗜血杆菌，莫萨拉， 大肠杆菌属，衣原体属，支原体属，军团菌属，分枝杆菌属，幽门螺杆菌属，梭菌属，拟杆菌属，棒状杆菌属，芽孢杆菌属或肠杆菌属，以及真菌生物体，例如曲霉属，布氏酵母属，假丝酵母​​属，椰子球菌属，隐球菌属，表皮生长素，亨氏嗜血菌属，组织胞浆菌属，微孢子虫属，拟青霉菌属， ，肺孢子虫（Pneumocystis），毛癣菌（Trichophyton）或三孢子虫（Trichosporium）。 还提供了制备这些化合物的方法，其药物组合物和治疗微生物感染的方法。

公开(公告)号：US08076370B2

公开(公告)日：2011-12-13

申请号：US11913380

申请日：2006-05-03

申请人： Biswajit Das ,  Jasbir Singh Arora ,  Shahadat Ahmed ,  Anish Bandyopadhyay ,  Rita Katoch ,  Santosh Haribhau Kurhade ,  Sujata Rathy ,  Soma Ghosh ,  Abhijit Datta Khoje ,  Arti Gujrati ,  Dilip J. Upadhyay

发明人： Biswajit Das ,  Jasbir Singh Arora ,  Shahadat Ahmed ,  Anish Bandyopadhyay ,  Rita Katoch ,  Santosh Haribhau Kurhade ,  Sujata Rathy ,  Soma Ghosh ,  Abhijit Datta Khoje ,  Arti Gujrati ,  Dilip J. Upadhyay

IPC分类号： A61K31/27 ,  A61K31/18 ,  A61K31/155 ,  A61K31/44 ,  A61K31/501 ,  C07D213/72 ,  C07C333/00 ,  C07C303/00 ,  C07C277/00

CPC分类号： C07D209/48 ,  C07D213/81 ,  C07D213/82 ,  C07D231/20 ,  C07D239/42 ,  C07D249/12 ,  C07D277/36 ,  C07D295/096 ,  C07D307/68 ,  C07D333/34 ,  C07D333/38 ,  C07D333/62 ,  C07D409/04 ,  C07D409/12 ,  C07D413/04 ,  C07D513/04

摘要： Provided herein are substituted aromatic compounds, which are tRNA synthetase inhibitors, and hence can be used as antimicrobial agents. Compounds described herein can be used for the treatment or prevention of a condition caused by or contributed to by gram positive, gram negative, anaerobic bacteria or fungal organisms, more particularly against bacterium, for example, Staphylococci, Enterococci, Streptococci, Haemophilus, Moraxalla, Escherichia, Chlamydia, Mycoplasm, Legionella, Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus or Enterobactericeae, and fungal organisms, for example, Aspergillus, Blastomyces, Candida, Coccidiodes, Cryptococcus, Epidermophyton, Hendersonula, Histoplasma, Microsporum, Paecilomyces, Paracoccidiodes, Pneumocystis, Trichophyton, or Trichosporium. Processes for the preparation of these compounds, pharmaceutical compositions thereof, and methods of treating microbial infections are also provided.

摘要翻译： 本文提供的是取代的芳族化合物，其是tRNA合成酶抑制剂，因此可以用作抗微生物剂。 本文所述的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性，厌氧菌或真菌生物引起或促成的病症，特别是针对细菌，例如葡萄球菌，肠球菌，链球菌，嗜血杆菌，莫萨拉， 大肠杆菌属，衣原体属，支原体属，军团菌属，分枝杆菌属，幽门螺杆菌属，梭菌属，拟杆菌属，棒状杆菌属，芽孢杆菌属或肠杆菌属，以及真菌生物体，例如曲霉属，布氏酵母属，假丝酵母​​属，椰子球菌属，隐球菌属，表皮生长素，亨氏嗜血菌属，组织胞浆菌属，微孢子虫属，拟青霉菌属， ，肺孢子虫（Pneumocystis），毛癣菌（Trichophyton）或三孢子虫（Trichosporium）。 还提供了制备这些化合物的方法，其药物组合物和治疗微生物感染的方法。