Oxazolidinone derivatives as antimicrobials
    2.
    发明授权
    Oxazolidinone derivatives as antimicrobials 失效
    恶唑烷酮衍生物作为抗微生物剂

    公开(公告)号:US07592335B2

    公开(公告)日:2009-09-22

    申请号:US11911576

    申请日:2006-04-12

    CPC classification number: Y02A50/478 Y02P20/55

    Abstract: Provided herein are novel substituted phenyl oxazolidinones and to processes for the synthesis thereof. Also provided are pharmaceutical compositions comprising one or more compounds described herein The compounds described can be useful antimicrobial agents, which can be effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiple-resistant staphylococci, streptococci and enterococci, as well as, anaerobic organisms, such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms, such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.

    Abstract translation: 本文提供了新的取代的苯基恶唑烷酮,以及其合成方法。 还提供了包含本文所述的一种或多种化合物的药物组合物。所述化合物可以是有用的抗微生物剂,其可以对许多人和兽医病原体有效,包括革兰氏阳性好氧细菌如多重耐药性葡萄球菌,链球菌和肠球菌 ,以及厌氧生物,如细菌属。 和梭菌属(Clostridia spp。) 物种和酸性快速生物,如结核分枝杆菌,鸟分枝杆菌和分枝杆菌。

    Use of Macrolide Derivatives for Treating Acne
    3.
    发明申请
    Use of Macrolide Derivatives for Treating Acne 审中-公开
    使用大环内酯衍生物治疗痤疮

    公开(公告)号:US20090075916A1

    公开(公告)日:2009-03-19

    申请号:US12094645

    申请日:2006-11-22

    CPC classification number: A61K31/7056

    Abstract: This invention relates to 14-membered macrolide derivatives for treating or preventing acne vulgaris and associated inflammatory conditions. Also provided herein are medicaments or pharmaceutical compositions comprising one or more 14-membered macrolide derivatives together with one or more pharmaceutically acceptable carriers, excipients, diluents or mixture thereof, and methods for treating or preventing acne vulgaris and associated inflammatory conditions.

    Abstract translation: 本发明涉及用于治疗或预防寻常痤疮和相关炎性病症的14-元大环内酯衍生物。 本文还提供包含一种或多种14-元大环内酯衍生物以及一种或多种药学上可接受的载体,赋形剂,稀释剂或其混合物的药物或药物组合物,以及治疗或预防寻常痤疮和相关炎性病症的方法。

    Ultrahigh vacuum process for the deposition of nanotubes and nanowires
    4.
    发明申请
    Ultrahigh vacuum process for the deposition of nanotubes and nanowires 有权
    用于沉积纳米管和纳米线的超高真空工艺

    公开(公告)号:US20090047427A1

    公开(公告)日:2009-02-19

    申请号:US12228529

    申请日:2008-08-13

    Abstract: A system and method A method of growing an elongate nanoelement from a growth surface includes: a) cleaning a growth surface on a base element; b) providing an ultrahigh vacuum reaction environment over the cleaned growth surface; c) generating a reactive gas of an atomic material to be used in forming the nanoelement; d) projecting a stream of the reactive gas at the growth surface within the reactive environment while maintaining a vacuum of at most 1×10−4 Pascal; e) growing the elongate nanoelement from the growth surface within the environment while maintaining the pressure of step c); f) after a desired length of nanoelement is attained within the environment, stopping direction of reactive gas into the environment; and g) returning the environment to an ultrahigh vacuum condition.

    Abstract translation: 一种系统和方法从生长表面生长细长纳米元素的方法包括:a)清洁基底元件上的生长表面; b)在清洁的生长表面上提供超高真空反应环境; c)产生用于形成纳米元素的原子材料的反应气体; d)在反应性环境中的生长表面处投射反应气体流,同时保持至多1×10 -4帕斯卡的真空度; e)在保持步骤c)的压力的同时从环境中的生长表面生长细长纳米元素; f)在环境中达到所需长度的纳米元素后,将反应气体停止进入环境的方向; 和g)使环境恢复到超高真空状态。

    3'-N-Substituted-3-O-Substituted Erythronolide a Derivatives
    5.
    发明申请
    3'-N-Substituted-3-O-Substituted Erythronolide a Derivatives 审中-公开
    3'-N-取代的3-O-取代的红霉素衍生物

    公开(公告)号:US20070270484A1

    公开(公告)日:2007-11-22

    申请号:US10573275

    申请日:2003-09-25

    CPC classification number: A61K31/7048 Y02A50/473

    Abstract: This invention generally relates to macrolides, more particularly, the invention relates to 3-N-substituted-3-O-substituted erythronolide A derivatives, which are antibacterial agents effective against gram positive or gram negative bacteria and atypical pathogens. The compounds of this invention are more particularly effective against Staphylococcus aureus, Streptococcus pneumoniae, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, Haemophilus influenzae. The invention also relates to a process for the preparation of the compounds of the present invention, pharmaceutical compositions containing the compounds of the present invention and the methods for treating bacterial infection.

    Abstract translation: 本发明一般涉及大环内酯类,更具体地说,本发明涉及3-N-取代-3-O-取代的红景天苷A衍生物,它们是对革兰氏阳性或革兰氏阴性细菌和非典型病原体有效的抗菌剂。 本发明的化合物对金黄色葡萄球菌,肺炎链球菌,粪肠球菌,大肠杆菌,铜绿假单胞菌,流感嗜血杆菌更为特别有效。 本发明还涉及制备本发明化合物的方法,含有本发明化合物的药物组合物和治疗细菌感染的方法。

    Oxazolidinone derivatives as antimicrobials
    6.
    发明授权
    Oxazolidinone derivatives as antimicrobials 失效
    恶唑烷酮衍生物作为抗微生物剂

    公开(公告)号:US06734307B2

    公开(公告)日:2004-05-11

    申请号:US09906215

    申请日:2001-07-16

    CPC classification number: C07D413/10 C07D413/12 C07D413/14

    Abstract: The present invention relates to certain substituted phenyl oxazolidinones and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.

    Abstract translation: 本发明涉及某些取代的苯基恶唑烷酮及其合成方法。 本发明还涉及含有作为抗微生物剂的本发明化合物的药物组合物。 这些化合物是有用的抗微生物剂,对许多人类和兽医病原体有效,包括革兰氏阳性好氧细菌如多重耐药性葡萄球菌,链球菌和肠球菌以及厌氧生物如细菌属。 和梭菌属(Clostridia spp。) 物种和酸性快速生物如结核分枝杆菌,鸟分枝杆菌和分枝杆菌属。

    Telemetric Sensing of Blood Flow Rates by Passive Infrared Temperature Sensing
    7.
    发明申请
    Telemetric Sensing of Blood Flow Rates by Passive Infrared Temperature Sensing 审中-公开
    通过被动红外温度传感测量血液流量的遥测

    公开(公告)号:US20140005554A1

    公开(公告)日:2014-01-02

    申请号:US13719729

    申请日:2012-12-19

    CPC classification number: A61B5/0261 A61B5/01

    Abstract: Systems enable a method of determining the rate of flow of a bodily fluid through a vessel in a live patient by: positioning at least two separate passive infrared sensors at two points along a length of the vessel; sensing local temperature changes at the two points along the vessel to generate signals of the local temperature changes from each passive infrared sensor; a processor receiving the signals and quantifying the local temperature changes at the two points; and the processor executing code to determine blood flow rate in the vessel from the local temperature changes quantified by the processor at the two points.

    Abstract translation: 系统使得能够通过以下方式确定身体流体通过活体患者血管的流速:在沿血管长度的两个点处定位至少两个单独的被动红外传感器; 检测沿船舶两点的局部温度变化,以产生每个被动红外传感器的局部温度变化信号; 处理器接收信号并量化两点处的局部温度变化; 并且所述处理器执行代码以从由所述两点处理器量化的局部温度变化来确定所述容器中的血液流量。

    Antibacterial Agents
    10.
    发明申请
    Antibacterial Agents 审中-公开
    抗菌剂

    公开(公告)号:US20080318878A1

    公开(公告)日:2008-12-25

    申请号:US11576033

    申请日:2005-09-27

    CPC classification number: C07H17/08

    Abstract: The present invention provides acylide derivatives, which can be used as antibacterial agents. Compounds disclosed herein can be used for treating or preventing conditions caused by or contributed to by Gram-positive, Gram-negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp., Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus, Enterobactericeae or any combination thereof. Also provided are processes for preparing compounds disclosed herein, pharmaceutical compositions thereof, and method of treating bacterial infections.

    Abstract translation: 本发明提供可用作抗菌剂的酰化物衍生物。 本文公开的化合物可用于治疗或预防由革兰氏阳性,革兰氏阴性或厌氧细菌引起或促成的病症,特别是针对例如葡萄球菌,链球菌,肠球菌,嗜血杆菌,马克拉斯氏菌属,衣原体属(Chlamydia spp。 ,支原体属,军团菌属,分枝杆菌属,幽杆菌属,梭菌属,拟杆菌属,棒状杆菌属,芽孢杆菌属,肠杆菌属或其任何组合。 还提供了制备本文公开的化合物的方法,其药物组合物和治疗细菌感染的方法。

Patent Agency Ranking