公开(公告)号：US20110003733A1

公开(公告)日：2011-01-06

申请号：US12788480

申请日：2010-05-27

Applicant: FAUSTO PIVETTI ,  MONICA BOCCHI ,  ANNAMARIA SOLIANI RASCHINI

Inventor： FAUSTO PIVETTI ,  MONICA BOCCHI ,  ANNAMARIA SOLIANI RASCHINI

IPC: A61K38/16 ,  A61P11/00

CPC classification number: C07K14/785 ,  A61K9/0082 ,  A61K38/395

Abstract: Reconstituted pulmonary surfactants comprising a lipid carrier, a combination of polypeptide analog of the native surfactant protein SP-C with a particular polypeptide analog of the native surfactant protein SP-B may be used for the treatment or prophylaxis of RDS and other respiratory disorders.

Abstract translation: 包含脂质载体，天然表面活性蛋白SP-C的多肽类似物与天然表面活性蛋白SP-B的特定多肽类似物的组合的重组肺表面活性剂可用于治疗或预防RDS和其它呼吸系统疾病。

公开(公告)号：US07381402B2

公开(公告)日：2008-06-03

申请号：US11065569

申请日：2005-02-25

Applicant: David Lewis ,  David Ganderton ,  Brian Meakin ,  Maurizio Delcanale ,  Fausto Pivetti

Inventor： David Lewis ,  David Ganderton ,  Brian Meakin ,  Maurizio Delcanale ,  Fausto Pivetti

IPC: A61K9/12 ,  A61K9/08 ,  A61K31/47 ,  A61K31/4704 ,  A61M11/00 ,  A61M11/04 ,  A61M15/00 ,  A61M15/06

CPC classification number: A61K9/008 ,  A61K31/137 ,  A61K31/47 ,  A61K31/4704 ,  A61K47/02 ,  A61M15/009 ,  A61M2205/0222 ,  A61K2300/00

Abstract: Aerosol solution formulations for use in an aerosol inhaler which comprise 8-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]-ethyl]-2(1H)-quinolinone or a salt thereof, in particular the hydrochloride salt (TA 2005), as an active ingredient, a propellant containing a hydrofluoroalkane, and a cosolvent, stabilized by addition of a specific small amount of a high concentrated phosphoric acid exhibit improved shelf life. The formulation may be optionally contained in a can having part or all of its internal metallic surfaces lined with an inert organic coating.

Abstract translation: 用于气溶胶吸入器的气溶胶溶液制剂，其包含8-羟基-5 - [（1R）-1-羟基-2 - [[（1R）-2-（4-甲氧基苯基）-1-甲基乙基]氨基] - 乙基 ] -2（1H） - 喹啉酮或其盐，特别是盐酸盐（TA 2005）作为活性成分，含有氢氟烷烃和助溶剂的推进剂，通过加入特定量的高浓度 磷酸表现出改善的保质期。 制剂可以任选地包含在其内部具有惰性有机涂层的部分或全部内部金属表面的罐中。

公开(公告)号：US20070197586A1

公开(公告)日：2007-08-23

申请号：US10593571

申请日：2005-03-24

Applicant: Fausto Pivetti ,  Roberto Pighl

Inventor： Fausto Pivetti ,  Roberto Pighl

IPC: A61K31/4704

CPC classification number: C07D207/48 ,  C07D215/26 ,  C07D215/60

Abstract: The invention relates to 8-hydroxy-5-[(1R)-1-hydroxy-2[[(1R)-2-(4-methoxyphenyl)-1-methyl ethyl]amino]ethyl]-2 (1 H)-quinolinone monohydrochloride of formula (I) in crystalline form, provided with suitable characteristics in order to be used for the preparation of pharmaceutical compositions for inhalation in combination with suitable carriers or vehicles and the process for its preparation.

Abstract translation: 本发明涉及8-羟基-5 - [（1R）-1-羟基-2 [[（1R）-2-（4-甲氧基苯基）-1-甲基乙基]氨基]乙基] -2（1H） 具有结晶形式的式（I）的喹啉酮单盐酸盐，其具有适合的特性，以用于与合适的载体或载体组合用于制备用于吸入的药物组合物及其制备方法。

公开(公告)号：US20070025920A1

公开(公告)日：2007-02-01

申请号：US11467515

申请日：2006-08-25

Applicant: David Lewis ,  David Ganderton ,  Brian Meakin ,  Maurizio Delcanale ,  Fausto Pivetti

Inventor： David Lewis ,  David Ganderton ,  Brian Meakin ,  Maurizio Delcanale ,  Fausto Pivetti

IPC: A61L9/04 ,  A61K31/4704

CPC classification number: A61K31/4704 ,  A61K9/008 ,  A61K47/02 ,  A61M15/009

Abstract: Aerosol solution formulations for use in an aerosol inhaler include 8-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methyl ethyl]amino]ethyl]-2(1H)-quinolinone or a salt thereof, preferably the hydrochloride thereof, as an active ingredient, a propellant containing a hydrofluoroalkane, and a cosolvent, stabilized by addition of a specific small amount of a high concentrated phosphoric acid and optionally by the use of a suitable can having part or all of its internal metallic surfaces lined with an inert organic coating.

Abstract translation: 用于气溶胶吸入器的气溶胶溶液制剂包括8-羟基-5 - [（1R）-1-羟基-2 - [[（1R）-2-（4-甲氧基苯基）-1-甲基乙基]氨基]乙基] -2（1H） - 喹啉酮或其盐，优选其盐酸盐作为活性成分，含有氢氟烷烃和助溶剂的推进剂，通过加入特定量的高浓度磷酸和任选地通过 使用合适的罐，其具有内部具有惰性有机涂层的部分或全部内部金属表面。

公开(公告)号：US20050220718A1

公开(公告)日：2005-10-06

申请号：US11065569

申请日：2005-02-25

Applicant: David Lewis ,  David Ganderton ,  Brian Meakin ,  Maurizio Delcanale ,  Fausto Pivetti

Inventor： David Lewis ,  David Ganderton ,  Brian Meakin ,  Maurizio Delcanale ,  Fausto Pivetti

IPC: A61K9/00 ,  A61K9/12 ,  A61K31/47 ,  A61K31/4704 ,  A61L9/04 ,  A61M15/00 ,  B65D83/14

CPC classification number: A61K9/008 ,  A61K31/137 ,  A61K31/47 ,  A61K31/4704 ,  A61K47/02 ,  A61M15/009 ,  A61M2205/0222 ,  A61K2300/00

Abstract: Aerosol solution formulations for use in an aerosol inhaler which comprise 8-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]-ethyl]-2(1H)-quinolinone or a salt thereof, in particular the hydrochloride salt (TA 2005), as an active ingredient, a propellant containing a hydrofluoroalkane, and a cosolvent, stabilized by addition of a specific small amount of a high concentrated phosphoric acid exhibit improved shelf life. The formulation may be optionally contained in a can having part or all of its internal metallic surfaces lined with an inert organic coating.

Abstract translation: 用于气溶胶吸入器的气溶胶溶液制剂，其包含8-羟基-5 - [（1R）-1-羟基-2 - [[（1R）-2-（4-甲氧基苯基）-1-甲基乙基]氨基] - 乙基 ] -2（1H） - 喹啉酮或其盐，特别是盐酸盐（TA 2005）作为活性成分，含有氢氟烷烃和助溶剂的推进剂，通过加入特定量的高浓度 磷酸表现出改善的保质期。 制剂可以任选地包含在其内部具有惰性有机涂层的部分或全部内部金属表面的罐中。