公开(公告)号：US20250011450A1

公开(公告)日：2025-01-09

申请号：US18749445

申请日：2024-06-20

Applicant: Genentech, Inc.

Inventor： Gregory Alan LAZAR ,  Brandon LEONARD ,  Matthew G. ROMEI

IPC: C07K16/28 ,  C12N15/10

Abstract: Provided herein are antibodies such as human or humanized antibodies with a modified heavy chain variable (VH) domain such that the antibodies adopt a constrained conformation (e.g., an i-shaped format) upon engaging the antigen(s) the antibodies bind to, thereby confer agonistic activities. In some cases, the antibodies are full-length antibodies (e.g., IgG antibodies). In some cases, the antibodies are monovalent antibodies (e.g., Fabs). In some cases, the antibodies target receptors which require clustering for activation (e.g., TNFR superfamily receptors). In some cases, the antibodies target two antigens on a molecule that have two or more subunits (e.g., an IL-2 receptor). Also provided herein are methods of making and using such antibodies and libraries for discovering or screening such antibodies.

公开(公告)号：US20250002609A1

公开(公告)日：2025-01-02

申请号：US18740409

申请日：2024-06-11

Applicant: Genentech, Inc.

Inventor： Cecilia P.C. CHIU ,  Hilda Y. HERNANDEZ-BARRY ,  David B. IAEA ,  Moulay Hicham ALAOUI-ISMAILI ,  James T. KOERBER ,  Wei Yu LIN ,  Kelly LOYET ,  Yonglian SUN ,  Benjamin T. WALTERS ,  Jawahar SUDHAMSU

IPC: C07K16/40 ,  A61K47/68

Abstract: The invention provides anti-KLK5 antibodies and methods of using the same.

公开(公告)号：US20250000812A1

公开(公告)日：2025-01-02

申请号：US18886607

申请日：2024-09-16

Applicant: Genentech, Inc.

Inventor： Dennis Hengho LEUNG

IPC: A61K9/51 ,  A61K31/192 ,  A61K31/343

Abstract: Described herein, in certain aspects, are nano-suspensions comprising a plurality of nanoparticles comprising a hydrophobic agent suspended in an aqueous carrier having a desired viscosity. In other aspects, the described herein are methods of use thereof, including methods of making a dosage form, components of the nano-suspensions, dispensing cartridges and composition therein, dosage forms, devices for dispensing a nano-suspension, and system and applications of the embodiments described herein.

公开(公告)号：US20250000473A1

公开(公告)日：2025-01-02

申请号：US18883384

申请日：2024-09-12

Applicant: GENENTECH, INC.

Inventor： Nils Gustav Thomas BENGTSSON ,  Richard Alan Duray CARANO ,  Alexander James Stephen CHAMPION DE CRESPIGNY ,  Jill Osborn FREDRICKSON ,  Mohamed Skander JEMAA

IPC: A61B6/00 ,  G06N3/02 ,  G06T7/11 ,  G06T7/174 ,  G16H10/20 ,  G16H30/20 ,  G16H30/40 ,  G16H50/20 ,  G16H50/30 ,  G16H50/50

Abstract: The present disclosure relates to techniques for segmenting tumors with positron emission tomography (PET) using deep convolutional neural networks for image and lesion metabolism analysis. Particularly, aspects of the present disclosure are directed to obtaining a PET scans and computerized tomography (CT) or magnetic resonance imaging (MRI) scans for a subject, preprocessing the PET scans and the CT or MRI scans to generate standardized images, generating two-dimensional segmentation masks, using two-dimensional segmentation models implemented as part of a convolutional neural network architecture that takes as input the standardized images, generating three-dimensional segmentation masks, using three-dimensional segmentation models implemented as part of the convolutional neural network architecture that takes as input patches of image data associated with segments from the two-dimensional segmentation mask, and generating a final imaged mask by combining information from the two-dimensional segmentation masks and the three-dimensional segmentation masks.

公开(公告)号：US20240428189A1

公开(公告)日：2024-12-26

申请号：US18828915

申请日：2024-09-09

Applicant: Genentech, Inc.

Inventor： Richard William Alas ,  Paul Gregoire Deroulhac

IPC: G06Q10/087

Abstract: Pharmaceutical asset tracking systems and methods for pharmaceutical asset tracking are disclosed. The system comprises a pharmaceutical asset tracker to transmit pharmaceutical asset information to a communications device. The pharmaceutical asset information comprises an identifier for a pharmaceutical asset associated with the pharmaceutical asset tracker in a defined area. The communications device is responsive to communications via a crowdsourcing protocol, and the pharmaceutical asset tracker transmits the pharmaceutical asset information to the communications device via the responsive crowdsourcing protocol. The system comprises a server configured to receive the pharmaceutical asset information and location information from the communications device. The server may determine, based on the location information, a location of the asset, and provide for display information regarding a group of pharmaceutical assets determined to be at a specified location. The group is identified based on pharmaceutical asset information for each of the assets in the group.

公开(公告)号：US20240426835A1

公开(公告)日：2024-12-26

申请号：US18825647

申请日：2024-09-05

Applicant: Genentech, Inc.

Inventor： Ann Marie Woys ,  Kathryn Margaret Mansfield Messina

IPC: G01N33/68 ,  C08F220/14 ,  C08F220/18 ,  C08F220/28 ,  C08F220/34 ,  C08F220/60

Abstract: This application relates to random polymer libraries and specific polymers that can be used, for example, in stabilizing high concentration protein compositions, such as high concentration antibody compositions.

公开(公告)号：US20240425615A1

公开(公告)日：2024-12-26

申请号：US18673164

申请日：2024-05-23

Applicant: Genentech, Inc.

Inventor： Nicholas J. ARMSTRONG ,  Mayumi N. BOWEN ,  Yuh-Fun MAA

IPC: C07K16/40 ,  A61K9/00 ,  A61K9/10 ,  A61K9/16 ,  A61K39/395 ,  C07K16/22 ,  C07K16/28 ,  C07K16/32

Abstract: The present application discloses high-concentration monoclonal antibody formulations suitable for subcutaneous administration, e.g. via a pre-filled syringe. In particular, it discloses a formulation comprising a spray dried monoclonal antibody at a concentration of about 200 mg/mL or more suspended in a non-aqueous suspension vehicle where the viscocity of the suspension vehicle is less than about 20 centipoise. Also disclosed are: a subcutaneous administration device with the formulation therein, a method of making the formulation, a method of making an article of manufacture comprising the suspension formulation, use of the formulation in the preparation of a medicament, and a method of treating a patient with the formulation.

公开(公告)号：US20240410009A1

公开(公告)日：2024-12-12

申请号：US18815555

申请日：2024-08-26

Applicant: GENENTECH, INC.

Inventor： Michael Townsend ,  Alvernia Francesca Setiadi ,  Tracy Staton

IPC: C12Q1/6883 ,  A61K39/00 ,  A61K39/395 ,  C07K16/24 ,  C07K16/28 ,  G01N33/564

Abstract: The present invention concerns markers of multiple sclerosis, their use, and treatment with IL-17 antagonists, including IL-17 antibodies, of subjects with increased levels of such markers.

公开(公告)号：US20240409657A1

公开(公告)日：2024-12-12

申请号：US18814259

申请日：2024-08-23

Applicant: Genentech, Inc.

Inventor： Matthew Dominic CASCINO

IPC: C07K16/28 ,  A61K31/138 ,  A61K31/167 ,  A61K31/34 ,  A61K31/5377 ,  A61K31/573 ,  A61K39/00 ,  A61K39/395 ,  A61P37/06

Abstract: The present disclosure provides methods for treating lupus nephritis in an individual that has lupus. In some embodiments, the methods comprise administering to the individual an effective amount of a type II anti-CD20 antibody. In other aspects, the present disclosure provides methods for treating membranous nephropathy.

公开(公告)号：US20240409615A1

公开(公告)日：2024-12-12

申请号：US18752501

申请日：2024-06-24

Applicant: Genentech, Inc.

Inventor： Chi Kin Domingos Ng ,  Amy Shen ,  Gavin Christian Barnard

IPC: C07K16/00 ,  C12N15/85

Abstract: The presently disclosed subject matter relates to multi-vector recombinase mediated cassette exchange approaches to achieve targeted integration of sequences of interest for the generation host cells expressing recombinant proteins, e.g., monoclonal antibodies, as well as compositions derived from the same, e.g., bispecific antibodies, and other complex format proteins, e.g., membrane protein complexes, and other difficult to express molecules.