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93 条记录 (耗时 0.042 秒)

    Heterocyclic inhibitors of MEK and methods of use thereof
    21.
    发明授权
    Heterocyclic inhibitors of MEK and methods of use thereof 失效
    MEK的杂环抑制剂及其使用方法

    公开(公告)号：US07511058B2

    公开(公告)日：2009-03-31

    申请号：US11410336

    申请日：2006-04-24

    申请人： T. Brian Hurley ,  Eli M. Wallace ,  Joseph P. Lyssikatos ,  James Blake

    发明人： T. Brian Hurley ,  Eli M. Wallace ,  Joseph P. Lyssikatos ,  James Blake

    IPC分类号： A61K31/437 ,  C07D471/02

    CPC分类号： C07D471/04 ,  C07D261/20

    摘要： Disclosed are compounds of the Formula III and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8, R9 R10, and W are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.

    摘要翻译： 公开了式III的化合物及其药学上可接受的盐和前药，其中R 1，R 2，R 7，R 8，R 9 R 10和W如说明书中所定义。 这些化合物是MEK抑制剂，可用于治疗哺乳动物中的过度增生性疾病，例如癌症和炎症。 还公开了使用这些化合物治疗哺乳动物中过度增殖性疾病的方法和含有这些化合物的药物组合物。

    Internal antenna for handheld mobile phones and wireless devices
    22.
    发明授权
    Internal antenna for handheld mobile phones and wireless devices 有权
    用于手持移动电话和无线设备的内部天线

    公开(公告)号：US07400302B2

    公开(公告)日：2008-07-15

    申请号：US11343167

    申请日：2006-01-30

    申请人： James Blake Winter

    发明人： James Blake Winter

    IPC分类号： H01Q1/24 ,  H01Q1/48

    CPC分类号： H01Q1/243 ,  H01Q1/48

    摘要： An antenna for a foldable wireless device is provided. The foldable wireless device and antenna include a first housing and a second housing pivotally connected. A printed circuit board associated with the wireless device comprises a first PCB in the first housing and a second PCB in the second housing. The first and second PCB function as first and second radiating plates respectively. A gap, generally aligned with the pivotal connection separates the first and second PCBs. A short is provided that traverses the gap and connects the first and second PCBs. Radio frequency power is connected to the first and second PCB to supply radio frequency power.

    摘要翻译： 提供了一种用于可折叠无线设备的天线。 可折叠无线装置和天线包括第一壳体和枢轴连接的第二壳体。 与无线装置相关联的印刷电路板包括第一壳体中的第一PCB和第二壳体中的第二PCB。 第一和第二PCB分别作为第一和第二辐射板。 通常与枢转连接对准的间隙分离第一和第二PCB。 提供穿过间隙并连接第一和第二PCB的短路。 射频电源连接到第一和第二PCB以提供射频功率。

    Heterocyclic inhibitors of MEK and methods of use thereof
    24.
    发明授权
    Heterocyclic inhibitors of MEK and methods of use thereof 失效
    MEK的杂环抑制剂及其使用方法

    公开(公告)号：US07271178B2

    公开(公告)日：2007-09-18

    申请号：US11410343

    申请日：2006-04-24

    申请人： Eli M. Wallace ,  James Blake

    发明人： Eli M. Wallace ,  James Blake

    IPC分类号： C07D471/04 ,  A61K31/437

    CPC分类号： C07D471/04 ,  C07D261/20

    摘要： Disclosed are compounds of the Formula V and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8, R9, R10, R11 and W are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.

    摘要翻译： 公开了式V的化合物及其药学上可接受的盐和前药，其中R 1，R 2，R 7，R 4， 8，R 9，R 10，R 11和W如说明书中所定义。 这些化合物是MEK抑制剂，可用于治疗哺乳动物中的过度增生性疾病，例如癌症和炎症。 还公开了使用这些化合物治疗哺乳动物中过度增殖性疾病的方法和含有这些化合物的药物组合物。

    Antenna efficiency test device
    26.
    发明授权
    Antenna efficiency test device 有权
    天线效率测试装置

    公开(公告)号：US07109932B2

    公开(公告)日：2006-09-19

    申请号：US10871432

    申请日：2004-06-18

    申请人： Govind R. Kadambi ,  Ram M. Narayanan ,  Yeqin Huang ,  Gordon Evert ,  James Blake Winter

    发明人： Govind R. Kadambi ,  Ram M. Narayanan ,  Yeqin Huang ,  Gordon Evert ,  James Blake Winter

    IPC分类号： G01R29/10 ,  H04B17/00

    CPC分类号： G01R29/105

    摘要： The present invention provides, an antenna test device to test antenna efficiency. The test device includes a cavity formed by at least one conductive sidewall. The cavity contains at least one tuning probe, at least one movable portion, or a combination thereof. The tuning probes and/or movable portion help inhibit the antenna under test from having faulty measurements due to anti resonance or coupling.

    摘要翻译： 本发明提供一种用于测试天线效率的天线测试装置。 测试装置包括由至少一个导电侧壁形成的空腔。 空腔包含至少一个调谐探针，至少一个可移动部分或其组合。 调谐探针和/或可移动部分有助于阻止被测天线由于抗共振或耦合而产生故障测量。

    Shear wall aspect ratio reducing frame (ARRF)
    28.
    发明申请
    Shear wall aspect ratio reducing frame (ARRF) 审中-公开
    剪切墙纵横比缩小框架（ARRF）

    公开(公告)号：US20050284084A1

    公开(公告)日：2005-12-29

    申请号：US10861676

    申请日：2004-06-04

    申请人： James Blake

    发明人： James Blake

    IPC分类号： E04B1/26 ,  E04C3/30

    CPC分类号： E04B1/26 ,  E04B2001/268 ,  E04B2001/2696

    摘要： My invention, the Shear Wall Aspect Ratio Reducing Frame is a simple, economical, efficient, easy to install device that allows greater oppotunity and flexibility in the size and location of openings in the walls of wood frame constructed buildings particularly houses. The ARRF would replace the commercial, pre-fabricated systems now in use which are costly and inefficient labor-intensive shear wall devices. The ARRF achieves its goal by reducing the moment arm in the overturning equations that are used to determine the uplift forces in a shear wall. The ARRF reduces forces in walls rather than increase their bulk which is the strategic concept now in use throughout the design professions and the construction industry to solve the aspect ratio problem.

    摘要翻译： 我的发明，剪切墙纵横比减速框架是一种简单，经济，高效，易于安装的设备，可以在木框架建筑物，特别是房屋的墙壁上的开口尺寸和位置上实现更大的对抗性和灵活性。 ARRF将取代现在使用的商业，预制的系统，这些系统是昂贵且无效的劳动密集型剪力墙装置。 ARRF通过减少用于确定剪力墙隆起力的倾覆方程中的力矩臂来实现其目标。 ARRF减少墙壁的力量，而不是增加其体积，这是现在在整个设计行业和建筑行业使用的战略概念来解决纵横比问题。