公开(公告)号：US5919452A

公开(公告)日：1999-07-06

申请号：US192861

申请日：1994-02-04

Applicant: Junming Le ,  Jan Vilcek ,  Peter Dadonna ,  John Ghrayeb ,  David Knight ,  Scott Seigal

Inventor： Junming Le ,  Jan Vilcek ,  Peter Dadonna ,  John Ghrayeb ,  David Knight ,  Scott Seigal

IPC: A61K38/00 ,  C07K14/525 ,  C07K16/24 ,  A61K39/395

CPC classification number: C07K14/525 ,  C07K16/241 ,  A61K38/00 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2319/00

Abstract: Treatment of tumor necrosis factor, TNF, mediated pathologies is provided by administering anti-TNF compounds, such as anti-TNF antibodies and anti-TNF peptides, which compounds are specific for tumor necrosis factor-.alpha. (TNF.alpha.) or tumor necrosis factor-.beta. (TNF.beta.) and which are useful for in vivo therapy or diagnosis of TNF.alpha.-mediated pathologies and conditions, wherein the anti-TNF compound is selected from the group consisting of at least one of an immunoglobulin variable region, a fragment of a TNF receptor and an anti-TNF peptide, such as a structural analog of a anti-TNF antibody fragment or a TNF receptor fragment.

Abstract translation: 肿瘤坏死因子，肿瘤坏死因子介导的病理学的治疗是通过施用抗TNF化合物，例如抗TNF抗体和抗TNF肽来提供的，该化合物对肿瘤坏死因子-α（TNFα）或肿瘤坏死因子-α β（TNFβ），其可用于TNFα介导的病理学和病症的体内治疗或诊断，其中所述抗TNF化合物选自免疫球蛋白可变区， TNF受体和抗TNF肽，例如抗TNF抗体片段或TNF受体片段的结构类似物。

公开(公告)号：US20090022718A1

公开(公告)日：2009-01-22

申请号：US12001071

申请日：2007-12-07

Applicant: Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

Inventor： Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

IPC: A61K39/395 ,  A61P9/00

CPC classification number: C07K16/241 ,  A61K31/167 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K31/485 ,  A61K31/573 ,  A61K38/00 ,  A61K39/3955 ,  A61K2039/505 ,  C07K14/525 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2319/00 ,  A61K2300/00

Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

Abstract translation: 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸 提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。

公开(公告)号：US07425330B2

公开(公告)日：2008-09-16

申请号：US11582153

申请日：2006-10-16

Applicant: Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

Inventor： Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

IPC: A61K39/295 ,  C07K16/24

CPC classification number: C07K16/241 ,  A61K31/167 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K31/485 ,  A61K31/573 ,  A61K38/00 ,  A61K39/3955 ,  A61K2039/505 ,  C07K14/525 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2319/00 ,  A61K2300/00

Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

Abstract translation: 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸 提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。

公开(公告)号：US07404955B2

公开(公告)日：2008-07-29

申请号：US11195589

申请日：2005-08-02

Applicant: Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

Inventor： Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

IPC: A61K39/395 ,  C07K16/24

CPC classification number: C07K16/241 ,  A61K31/167 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K31/485 ,  A61K31/573 ,  A61K38/00 ,  A61K39/3955 ,  A61K2039/505 ,  C07K14/525 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2319/00 ,  A61K2300/00

Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

Abstract translation: 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸 提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。

公开(公告)号：US07252823B2

公开(公告)日：2007-08-07

申请号：US10774118

申请日：2004-02-06

Applicant: Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

Inventor： Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

IPC: A61K39/395 ,  C07K16/28

CPC classification number: A61K39/3955 ,  A61K31/167 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K31/485 ,  A61K31/519 ,  A61K31/573 ,  A61K38/00 ,  A61K45/00 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/525 ,  C07K16/241 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  A61K2300/00

Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

公开(公告)号：US07241733B2

公开(公告)日：2007-07-10

申请号：US10609783

申请日：2003-06-30

Applicant: George A. Heavner ,  David M. Knight ,  John Ghrayeb ,  Bernard J. Scallon ,  Thomas C. Nesspor ,  Karen A. Kutoloski

Inventor： George A. Heavner ,  David M. Knight ,  John Ghrayeb ,  Bernard J. Scallon ,  Thomas C. Nesspor ,  Karen A. Kutoloski

IPC: C07K14/505

CPC classification number: C07K16/00 ,  A61K38/00 ,  C07K16/2863 ,  C07K2317/52 ,  C07K2317/53 ,  C07K2317/74 ,  C07K2317/75 ,  C07K2319/30

Abstract: The present invention relates to at least one novel human EPO mimetic CH1 deleted mimetibody or specified portion or variant, including isolated nucleic acids that encode at least one EPO mimetic CH1 deleted mimetibody or specified portion or variant, CH1 deleted mimetibody or specified portion or variants, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.

Abstract translation: 本发明涉及至少一种新的人EPO模拟CH1缺失的模拟体或特定部分或变体，包括编码至少一种EPO模拟CH1缺失的模拟体或特定部分或变体，CH1缺失的模拟体或特定部分或变体的分离的核酸， 载体，宿主细胞，转基因动物或植物，以及其制备和使用方法，包括治疗组合物，方法和装置。

公开(公告)号：US07214376B2

公开(公告)日：2007-05-08

申请号：US10010229

申请日：2001-12-07

Applicant: Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

Inventor： Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

IPC: A61K39/395 ,  C07K16/28

CPC classification number: C07K16/241 ,  A61K31/167 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K31/485 ,  A61K31/573 ,  A61K38/00 ,  A61K39/3955 ,  A61K2039/505 ,  C07K14/525 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2319/00 ,  A61K2300/00

Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

Abstract translation: 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸 提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。

公开(公告)号：US07160995B2

公开(公告)日：2007-01-09

申请号：US10200795

申请日：2002-07-22

Applicant: Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

Inventor： Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

IPC: C12N15/13 ,  C12N15/12 ,  C12N15/11 ,  C12N15/00

CPC classification number: A61K39/3955 ,  A61K31/167 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K31/485 ,  A61K31/519 ,  A61K31/573 ,  A61K38/00 ,  A61K45/00 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/525 ,  C07K16/241 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  A61K2300/00

Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

Abstract translation: 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸 提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。

公开(公告)号：US20060280742A1

公开(公告)日：2006-12-14

申请号：US11297655

申请日：2005-12-08

Applicant: Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

Inventor： Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

IPC: A61K39/395 ,  A61K31/60 ,  A61K31/192 ,  A61K31/485 ,  A61K31/405

CPC classification number: C07K16/241 ,  A61K31/167 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K31/485 ,  A61K31/573 ,  A61K38/00 ,  A61K39/3955 ,  A61K2039/505 ,  C07K14/525 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2319/00 ,  A61K2300/00

Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

Abstract translation: 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸 提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。

公开(公告)号：US07128907B2

公开(公告)日：2006-10-31

申请号：US10379866

申请日：2003-03-04

Applicant: Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

Inventor： Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

IPC: A61K39/395 ,  C07K16/28

CPC classification number: A61K39/3955 ,  A61K31/167 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K31/485 ,  A61K31/519 ,  A61K31/573 ,  A61K38/00 ,  A61K45/00 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/525 ,  C07K16/241 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  A61K2300/00

Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

Abstract translation: 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸 提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体或其片段，区域或衍生物的使用方法。