公开(公告)号：US20090017494A1

公开(公告)日：2009-01-15

申请号：US12200456

申请日：2008-08-28

申请人： Kevin S. Brandt

发明人： Kevin S. Brandt

IPC分类号： C12P21/00 ,  C07H21/00 ,  C12N7/01 ,  G01N33/68 ,  C07K16/00 ,  C12N5/00 ,  C07K14/00

CPC分类号： C07K14/70571 ,  C07K14/43527 ,  C07K14/4359 ,  C12N2799/021 ,  Y10S530/858

摘要： The present invention relates to tick octopamine receptor nucleic acid molecules; to tick octopamine receptor proteins encoded by such nucleic acid molecules; to antibodies raised against such proteins; and to compounds that inhibit the activity of such proteins. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. The present invention also includes inhibitory compounds, particularly those that specifically inhibit tick octopamine receptor activity, as well as the use of such compounds to treat animals.

摘要翻译： 本发明涉及蜱八萜胺受体核酸分子; 挑选由这种核酸分子编码的章鱼胺受体蛋白; 针对这种蛋白质产生的抗体; 以及抑制这些蛋白质活性的化合物。 本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。 本发明还包括抑制性化合物，特别是那些特异性抑制蜱八萜胺受体活性的化合物，以及这些化合物用于治疗动物的用途。

公开(公告)号：US07476728B2

公开(公告)日：2009-01-13

申请号：US10433140

申请日：2002-11-21

申请人： Nancy Wisnewski ,  Kevin S. Brandt

发明人： Nancy Wisnewski ,  Kevin S. Brandt

IPC分类号： C07H21/02

CPC分类号： C07K14/705 ,  A61K38/00 ,  G01N2500/04

摘要： The present invention relates to flea GABA receptor subunit nucleic acid molecules; to flea GABA receptor subunit proteins encoded by such nucleic acid molecules; to antibodies raised against such proteins; and to compounds that inhibit the activity of such proteins. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. The present invention also includes therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and inhibitory compounds, particularly those that specifically inhibit flea GABA receptor subunit activity, as well as the use of such therapeutic compositions to treat animals.

摘要翻译： 本发明涉及跳蚤GABA受体亚基核酸分子; 由这种核酸分子编码的跳蚤GABA受体亚基蛋白; 针对这种蛋白质产生的抗体; 以及抑制这些蛋白质活性的化合物。 本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和抑制性化合物，特别是那些特异性抑制跳蚤GABA受体亚基活性的化合物的治疗组合物，以及这些治疗组合物用于治疗动物的治疗组合物。