公开(公告)号：US20200206313A1

公开(公告)日：2020-07-02

申请号：US16724436

申请日：2019-12-23

Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT ,  INDIAN INSTITUTE OF SCIENCE

Inventor： Steven A. ROSENZWEIG ,  Hanudatta S. ATREYA ,  Asampilli GITANJALI ,  Paturu KONDAIAH

IPC: A61K38/17 ,  A61P35/00

Abstract: Provided herein is a self-assembling polypeptide-based nanotube system having the ability to target cancer cells. The nanotubes target the cancer cell surface through integrin engagement with the help of multiple RGD units present along their surface and release their drug payload in a sustained manner. In addition, the nanotubes can be utilized for cellular imaging using any covalently tagged fluorescent dye. Provided herein is a self-assembling polypeptide-based nanotube system having the ability to target cancer cells. The nanotubes target the cancer cell surface through integrin engagement with the help of multiple RGD units present along their surface and release their drug payload in a sustained manner. In addition, the nanotubes can be utilized for cellular imaging using any covalently tagged fluorescent dye.

公开(公告)号：US20200165182A1

公开(公告)日：2020-05-28

申请号：US16633464

申请日：2018-08-29

Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

Inventor： Nathan G. DOLLOFF ,  Reeder M. ROBINSON ,  Allen B. REITZ ,  Haiyan BIAN

IPC: C07C39/38 ,  C07D263/52 ,  C07C69/708 ,  A61P35/00 ,  C07C233/02 ,  C07D319/14 ,  C07C61/29 ,  C07C233/58 ,  C07D317/52 ,  C07C43/225

Abstract: The present invention relates to compounds of formula (I): including any stereochemically isomeric form thereof, or pharmaceutically acceptable salts thereof, for the treatment of, for example, cancer.

公开(公告)号：US10588670B2

公开(公告)日：2020-03-17

申请号：US16376893

申请日：2019-04-05

Applicant: MUSC Foundation for Research Development

Inventor： Barton L. Sachs

IPC: A61B17/56 ,  A61B17/58 ,  A61B17/80 ,  A61F2/30 ,  A61B17/70 ,  A61F2/44 ,  A61B17/86 ,  A61F2/46 ,  A61B17/68 ,  A61F2/28

Abstract: Anterior spinal implant devices for reducing spinal malalignment and associated systems and methods are disclosed herein. A spinal implant system configured in accordance with embodiments of the present technology can include, for example, a first vertebral support implanted at an anterior region of a first vertebra of a patient, a second vertebral support implanted at an anterior region of a second vertebra inferior to the first vertebra, and an alignment system configured to be releasably coupled to the first and second vertebral supports. The first and second vertebral supports can extend into and interlock with each other within an interbody space between the first and second vertebrae when the first and second vertebral supports are aligned. The alignment system is configured to reduce angular, vertical, and linear malalignment of the first and second vertebrae relative to each other.

公开(公告)号：US20200069239A1

公开(公告)日：2020-03-05

申请号：US16613522

申请日：2018-05-15

Applicant: MUSC Foundation for Research Development

Inventor： Nancey Trevanian Tsai ,  Mark E. Semler

IPC: A61B5/00 ,  A61B5/16 ,  A61B5/11 ,  G16H40/67 ,  G16H20/70 ,  G16H50/20

Abstract: A device for measuring eyelid movement in a human subject comprises a housing, at least one stimulator mounted to the housing, and a camera. The at least one stimulator is configured to provide stimulus to one or both eyes of the subject. The camera is configured to collect information related to movement of one or both eyes of the subject. The device also includes a user interface that is configured to control the at least one stimulator and display information collected by the camera.

公开(公告)号：US20200000334A1

公开(公告)日：2020-01-02

申请号：US16569940

申请日：2019-09-13

Applicant: MUSC Foundation for Research Development

Inventor： Nancey Trevanian Tsai ,  Mark Evald Semler

IPC: A61B3/113 ,  A61B5/11 ,  A61B3/00 ,  A61B3/11 ,  A61B3/14 ,  A61B5/00 ,  A61B5/0496

Abstract: A device for measuring eye movement in a human subject comprises a housing, at least one stimulator mounted to the housing, and a sensor. The at least one stimulator is configured to provide stimulus to one or both eyes of the subject. The sensor is configured to collect information related to movement of one or both eyes of the subject. The device also includes a user interface that is configured to control the at least one stimulator and display information collected by the camera.

公开(公告)号：US10456400B2

公开(公告)日：2019-10-29

申请号：US15307966

申请日：2015-05-15

Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

Inventor： Christopher C. Lindsey ,  Craig C. Beeson

IPC: A61K31/519 ,  C07D471/14

Abstract: In some aspects, the present invention relates to aza-ellipticine compounds of the formula: wherein the variables are as defined herein. The application also provides novel methods of preparing aza-ellipticine compounds, methods of using the compounds, and pharmaceutical compositions thereof.

公开(公告)号：US20190322984A1

公开(公告)日：2019-10-24

申请号：US16448208

申请日：2019-06-21

Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

Inventor： Mark RUBINSTEIN ,  David COLE

IPC: C12N5/0783 ,  C07K14/715 ,  A61K38/20 ,  A61K38/17 ,  C12N15/85 ,  C07K14/705 ,  A61K35/17

Abstract: Cells, such a T-cells, are provided that comprise cytokine receptors having increased activity in response to their ligand. For example, cell can comprise IL-2 and/or IL-15 receptors having increased surface expression or signaling activity. Cells of the embodiments have a significant growth advantage in the presence of cytokines and can be used, e.g., for enhanced adoptive cell transfer therapies.

公开(公告)号：US10441322B2

公开(公告)日：2019-10-15

申请号：US16168106

申请日：2018-10-23

Applicant: MUSC Foundation for Research Development

Inventor： Barton L. Sachs ,  Trevor James Langley ,  Fabiano Pace ,  Alexandra Kathryn Wells ,  Carolyn Chlebek ,  Christine Marie Perrone ,  Cara Elizabeth Yocum ,  Joshua Murphy Peterson

IPC: A61B17/70 ,  A61F2/44 ,  A61B17/86 ,  A61F2/46 ,  A61B17/56 ,  A61B17/68 ,  A61F2/28 ,  A61F2/30

Abstract: Anterior spinal implant devices for reducing spinal malalignment and associated systems and methods are disclosed herein. A spinal implant system configured in accordance with embodiments of the present technology can include, for example, a first vertebral support implanted at an anterior region of a first vertebra of a patient, a second vertebral support implanted at an anterior region of a second vertebra inferior to the first vertebra, and an alignment system configured to be releasably coupled to the first and second vertebral supports. The first and second vertebral supports can extend into and interlock with each other within an interbody space between the first and second vertebrae when the first and second vertebral supports are aligned. The alignment system is configured to reduce angular, vertical, and linear malalignment of the first and second vertebrae relative to each other.

公开(公告)号：US20190301029A1

公开(公告)日：2019-10-03

申请号：US16346181

申请日：2017-11-03

Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

Inventor： Harold D. MAY ,  Edward V. LABELLE

IPC: C25B3/04 ,  C25B9/06

Abstract: In some aspects, the present disclosure provides a method of bioelectric production of organic compounds such as acetate. In further aspects, the present disclosure also provides methods of producing a hydrocarbon based fuel using C02 as the carbon source.

公开(公告)号：US10385128B2

公开(公告)日：2019-08-20

申请号：US14972698

申请日：2015-12-17

Applicant: MUSC Foundation for Research Development

Inventor： Natalie Sutkowski ,  Daniel Fernandes ,  Brian Hoel ,  Semyon Rubinchik

IPC: A61K39/395 ,  C07K16/28 ,  C07K16/18 ,  C07K16/30 ,  A61K47/68

Abstract: The present invention provides for methods of producing human monoclonal antibodies to human nucleolin, cells producing such antibodies, and the antibodies themselves. Also provided are methods of using the antibodies in diagnosing and treating malignant and non-malignant diseases wherein cells that express nucleolin on the cell surface contribute to the pathophysiology of the disease.