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    INJECTABLE NEUROSTEROID FORMULATIONS CONTAINING NANOPARTICLES
    21.
    发明申请
    INJECTABLE NEUROSTEROID FORMULATIONS CONTAINING NANOPARTICLES 有权

    公开(公告)号：US20210128583A1

    公开(公告)日：2021-05-06

    申请号：US16992873

    申请日：2020-08-13

    申请人： MARINUS PHARMACEUTICALS, INC.

    发明人： Mingbao Zhang ,  Raymond C. Glowaky ,  David Czekai

    IPC分类号： A61K31/573 ,  A61K9/00 ,  A61K9/10 ,  A61K9/19 ,  A61K47/36 ,  A61K47/32 ,  A61K47/24 ,  A61K31/57 ,  A61K9/14 ,  A61K9/16 ,  A61K45/06

    摘要： The disclosure provides an injectable neurosteroid nanoparticle formulation comprising nanoparticles having a D50 of less than 2000 nm the nanoparticles comprising a neurosteroid of Formula I, where the variables R1-R9 and X are defined herein and at least one surface stabilizer,. The surface stabilizer can be a polymeric surface stabilizer such as hydroxyethyl starch, dextran, or povidone. The injectable neurosteroid nanoparticle formulation can be an intravenous formulation. The disclosure also provides a lyophilized powder of the injectable neurosteroid nanoparticle formulation that can be reconstituted in an aqueous solution prior to administration. The disclosure provides injectable neurosteroid nanoparticle formulations and dry powders of such formulations that have been sterilized by ebeam irradiation. The disclosure provides a method of treating a patient having a seizure disorder, stroke, or traumatic brain injury, comprising administering an effective amount of the injectable neurosteroid nanoparticle formulation. The disclosure also provides combination methods in which the injectable neurosteroid nanoparticle formulation is a first active agent that is administered in combination with at least one additional active agent.

    Injectable neurosteroid formulations containing nanoparticles
    22.
    发明授权
    Injectable neurosteroid formulations containing nanoparticles 有权

    公开(公告)号：US10780099B2

    公开(公告)日：2020-09-22

    申请号：US15294135

    申请日：2016-10-14

    申请人： MARINUS PHARMACEUTICALS, INC.

    发明人： Mingbao Zhang ,  Raymond C. Glowaky ,  David Czekai

    IPC分类号： A61K31/573 ,  A61K9/00 ,  A61K9/10 ,  A61K9/19 ,  A61K47/36 ,  A61K47/32 ,  A61K47/24 ,  A61K31/57 ,  A61K9/14 ,  A61K9/16 ,  A61K45/06

    摘要： The disclosure provides an injectable neurosteroid nanoparticle formulation comprising nanoparticles having a D50 of less than 2000 nm the nanoparticles comprising a neurosteroid of Formula I, where the variables R1-R9 and X are defined herein and at least one surface stabilizer. The surface stabilizer can be a polymeric surface stabilizer such as hydroxyethyl starch, dextran, or povidone. The injectable neurosteroid nanoparticle formulation can be an intravenous formulation. The disclosure also provides a lyophilized powder of the injectable neurosteroid nanoparticle formulation that can be reconstituted in an aqueous solution prior to administration. The disclosure provides injectable neurosteroid nanoparticle formulations and dry powders of such formulations that have been sterilized by ebeam irradiation. The disclosure provides a method of treating a patient having a seizure disorder, stroke, or traumatic brain injury, comprising administering an effective amount of the injectable neurosteroid nanoparticle formulation. The disclosure also provides combination methods in which the injectable neurosteroid nanoparticle formulation is a first active agent that is administered in combination with at least one additional active agent.