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    CARBOXYLIC ACID DERIVATIVES HAVING A 2,5-SUBSTITUTED OXAZOLOPYRIMIDINE RING
    23.
    发明申请
    CARBOXYLIC ACID DERIVATIVES HAVING A 2,5-SUBSTITUTED OXAZOLOPYRIMIDINE RING 有权
    具有2,5-取代的氧杂环糊精环的羧酸衍生物

    公开(公告)号：US20130079358A1

    公开(公告)日：2013-03-28

    申请号：US13521831

    申请日：2011-01-12

    Applicant: Dieter Kadereit ,  Matthias Schaefer ,  Stephanie Hachtel ,  Axel Dietrich ,  Thomas Huebschle ,  Katrin Hiss

    Inventor： Dieter Kadereit ,  Matthias Schaefer ,  Stephanie Hachtel ,  Axel Dietrich ,  Thomas Huebschle ,  Katrin Hiss

    IPC: C07D498/04

    CPC classification number: C07D498/04

    Abstract: The present invention relates to oxazolopyrimidine compounds of the formula I, in which A, R1, R2, R3 and X are defined as indicated in the claims. The compounds of the formula I modulate the activity of the Edg-1 receptor and in particular are agonists of this receptor, and are useful for the treatment of diseases such as atherosclerosis, heart failure or peripheral arterial occlusive disease, for example. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.

    Abstract translation: 本发明涉及式I的恶唑并嘧啶化合物，其中A，R 1，R 2，R 3和X如权利要求中所定义。 式I的化合物调节Edg-1受体的活性，特别是该受体的激动剂，并且可用于例如治疗动脉粥样硬化，心力衰竭或外周动脉闭塞性疾病等疾病。 本发明还涉及制备式I化合物的方法，其用途，特别是作为药物中的活性成分，以及包含它们的药物组合物。

    MIXING SYSTEM COMPRISING AN EXTENSIONAL FLOW MIXER
    25.
    发明申请
    MIXING SYSTEM COMPRISING AN EXTENSIONAL FLOW MIXER 有权
    包含扩展流量混合器的混合系统

    公开(公告)号：US20120287744A1

    公开(公告)日：2012-11-15

    申请号：US13519152

    申请日：2011-01-20

    Applicant: Maria Pollard ,  Steven R. Strand ,  David A. Eversdyk ,  Matthias Schaefer

    Inventor： Maria Pollard ,  Steven R. Strand ,  David A. Eversdyk ,  Matthias Schaefer

    IPC: B01F5/06 ,  B01F15/02

    CPC classification number: B01F5/0453 ,  B01F5/0451 ,  B01F5/0456

    Abstract: The invention provides a mixing system comprising the following: A) at least one extensional flow mixer comprising: a generally open and hollow body having a contoured outer surface and having: a single entrance port and a single exit port; a means for compressing a bulk stream flowing through the generally open and hollow body in a direction of flow, and at least one injected additive stream introduced at the single entrance port in the direction of flow; and a means for broadening the bulk stream and the at least one injected additive stream, such that an interfacial area between the bulk stream and the at least one injected additive stream is increased as the bulk stream and the at least one injected additive stream flow through the generally open and hollow body in the direction of flow to promote mixing of the bulk stream and the at least one injected additive stream; B) a flow conductor having an axis and having a generally open and hollow flow mixer body cured therein; and C) a primary additive stream injector positioned at the entrance port of the generally open and hollow flow mixer body, wherein the primary additive stream injector injects an additive stream into the interior of the flow mixer in the direction of flow, when the bulk stream is flowing through the generally open and hollow flow mixer body, to allow for compression and broadening of the bulk stream and the additive stream together within the extensional flow mixer, to facilitate mixing of the bulk stream and the primary additive stream at an exit of the extensional flow mixer; and wherein the extensional flow mixer is followed by D) at least one helical static mixing element that is at least one half “flow conductor diameter (D1)” downstream of the exit of the extensional flow mixer.

    Abstract translation: 本发明提供了一种混合系统，其包括以下步骤：A）至少一个延伸流动混合器，其包括：具有轮廓外表面的大体上敞开且中空的主体，具有：单个入口和单个出口; 用于沿着流动方向压缩流过所述大体上敞开的中空体的主体流和在所述单个入口处沿流动方向引入的至少一个注入的添加剂流的装置; 以及用于使本体流和至少一个注入的添加剂流扩宽的手段，使得当本体流和至少一个注入的添加剂流流过时，本体流和至少一个注入的添加剂流之间的界面面积增加 所述大体上敞开的空心体在所述流动方向上以促进所述主体流和所述至少一个注入的添加剂流的混合; B）具有轴线并具有固化在其中的大致开放且中空的流动混合器主体的流动导体; 以及C）位于所述大体上敞开的中空流动混合器主体的入口处的主要添加剂流注入器，其中所述主要添加剂流注入器在所述主流体流中将添加剂流沿所述流动方向注入所述流动混合器的内部 流过通常敞开的中空流动混合器主体，以允许在延伸流动混合器内将本体流和添加剂流压缩和变宽在一起，以促进本体流和初级添加剂流在 拉伸流动混合器; 并且其中所述拉伸流动混合器之后是D）至少一个螺旋形静态混合元件，其在所述拉伸流动混合器的出口下游具有至少一个半流动导体直径（D1）。

    PARAMETRIC CONTROL OF VOLUME STREAMS
    27.
    发明申请
    PARAMETRIC CONTROL OF VOLUME STREAMS 审中-公开
    体积流量的参数控制

    公开(公告)号：US20120226188A1

    公开(公告)日：2012-09-06

    申请号：US13391735

    申请日：2010-08-27

    Applicant: Matthias Schaefer ,  Andreas Gille

    Inventor： Matthias Schaefer ,  Andreas Gille

    IPC: A61M5/168 ,  A61B5/00 ,  A61B10/02

    CPC classification number: A61B10/0233 ,  A61B10/0045 ,  A61B2017/00022 ,  A61B2090/064 ,  A61M5/14 ,  A61M5/168 ,  A61M5/1723 ,  A61M2205/50

    Abstract: The invention relates to a medical device for infusion of an active ingredient or removal of a body tissue or body liquid comprising: a outlet device for infusion of an active ingredient to a body tissue; a receptacle for storing the active ingredient to which the outlet device is attachable; a sensor device for measuring a parameter which is related to a physical state in the body tissue; a drive device for effectuating at least an infusion of the active ingredient; characterized by a control unit functionally connected to the sensor device for receiving a sensor signal, which corresponds to the state of the body tissue, wherein the control unit is adapted for controlling a flow rate.

    Abstract translation: 本发明涉及一种用于输注活性成分或去除身体组织或身体液体的医疗装置，包括：用于将活性成分输注到身体组织的出口装置; 用于存储出口装置可附接到的活性成分的容器; 用于测量与身体组织中的物理状态相关的参数的传感器装置; 用于至少实现活性成分的输注的驱动装置; 其特征在于，与所述传感器装置功能性连接的控制单元，用于接收对应于所述身体组织的状态的传感器信号，其中所述控制单元适于控制流量。

    Chiplessly thread-forming screw
    29.
    发明申请
    Chiplessly thread-forming screw 有权
    无缝螺纹成型螺丝

    公开(公告)号：US20080038088A1

    公开(公告)日：2008-02-14

    申请号：US11804268

    申请日：2007-05-16

    Applicant: Sven Matthiesen ,  Frank Rieger ,  Peter Hertlein ,  Michael Baumgartner ,  Peter Mugg ,  Matthias Schaefer

    Inventor： Sven Matthiesen ,  Frank Rieger ,  Peter Hertlein ,  Michael Baumgartner ,  Peter Mugg ,  Matthias Schaefer

    IPC: F16B35/04

    CPC classification number: F16B25/0021 ,  F16B25/0047 ,  F16B25/0057

    Abstract: A chiplessly thread-forming screw has a stem (11) at one end of which a tip (13) is provided and at another end of which a head (14) is provided, and which has a pointed conical section (21) extending from the tip (13) in a direction of the head (14), a cylindrical section (25) arranged between the first pointed section (21) and the head (14), a first cambered section (22) adjoining the pointed conical section (21) in the direction of the head, and a second cambered section (24) arranged between the first cambered section (22) and the cylindrical section (25) and an outer surface (16) of which has a second curvature radius (R2) unequal to the first curvature radius (R1) of the outer surface (12) of the first cambered section (21).

    Abstract translation: 无芯螺纹形成螺钉具有杆（11），杆的一端处设置有尖端（13），并且其另一端设有头部（14），并且具有尖端的锥形部分（21），其从 所述头部（13）沿所述头部（14）的方向，布置在所述第一尖锐部分（21）和所述头部（14）之间的圆柱形部分（25），邻接所述尖形圆锥形部分的第一弧形部分（22） 21）和位于第一弧形部分（22）和圆柱形部分（25）之间的第二弧形部分（24），其外表面（16）具有第二曲率半径（R 2 ）不等于第一弧形部分（21）的外表面（12）的第一曲率半径（R 1）。

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