FULL CONTINUOUS SYNTHESIS DEVICE AND METHOD FOR METRONIDAZOLE

    公开(公告)号:US20240270696A1

    公开(公告)日:2024-08-15

    申请号:US18625925

    申请日:2024-04-03

    Abstract: A full continuous synthesis method of metronidazole is provided. An aqueous glyoxal solution, an aqueous acetaldehyde solution and aqueous ammonia are mixed and reacted to produce a 2-methylimidazole-containing reaction mixture, which is mixed with a nitric acid solution and then reacted in the presence of concentrated sulfuric acid to obtain a 2-methyl-5-nitroimidazole-containing reaction mixture. The 2-methyl-5-nitroimidazole-containing reaction mixture is divided by a splitter, such that one part is used to replace concentrated sulfuric acid, and the other part is mixed with formic acid, and undergoes a ring-opening reaction with ethylene oxide to obtain a metronidazole solution. The metronidazole solution is adjusted to pH 2-6 and filtered to obtain a filtrate, which is adjusted to pH 8-14 and filtered to obtain a crude product. The crude product is subjected to decoloring, crystallization, filtration and drying to obtain pure metronidazole with a purity greater than 99.9%.

    Corrugated grid support for vertical boiling reactor

    公开(公告)号:US12030028B2

    公开(公告)日:2024-07-09

    申请号:US17564658

    申请日:2021-12-29

    Abstract: A baffle (i.e., tube support) for use in a shell-and-tube heat exchange reactor, such as, for example, an ethylene oxide (EO) reactor, is provided that accommodates reduced tube pitch, and thus more catalyst packed tubes can be inside the reactor. The baffle, which can be referred to herein as a corrugated grid support, includes a plurality of corrugated stainless steel strips which sit into each other and form a grid pattern having tube openings. Each tube opening is configured to permit a catalyst packed tube to be inserted therein, while allowing a sufficient open area along the shell side of the tube to permit coolant to flow through the reactor.

    REACTOR FOR PROCESSING GAS
    6.
    发明公开

    公开(公告)号:US20230241574A1

    公开(公告)日:2023-08-03

    申请号:US17649795

    申请日:2022-02-02

    Applicant: RECARBON, INC.

    Abstract: A gas reactor may include a reactor chamber having a first end, a second end, and a lateral surface that extends between the first end and the second end. The gas reactor may include a torch inlet positioned at the first end of the reactor chamber, and the torch inlet may be configured for input flow of a fuel in a first flow direction. The gas reactor may include a reactant inlet positioned at the second end of the reactor chamber and configured to cause a reactant to flow into the reactor chamber in a second flow direction. The fuel or the reactant may move through the reactor chamber in a vortex flow pattern. The gas reactor may include an outlet port positioned at the second end of the reactor chamber in which the outlet port is configured for output flow of a product from the reactor chamber.

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