公开(公告)号：US06554801B1

公开(公告)日：2003-04-29

申请号：US09697571

申请日：2000-10-26

申请人： Jeffrey Steward ,  Mina Chow

发明人： Jeffrey Steward ,  Mina Chow

IPC分类号： A61M15118

CPC分类号： A61B8/12 ,  A61B5/4839 ,  A61B8/445 ,  A61M25/0084 ,  A61M25/104 ,  A61M37/0092 ,  A61M2025/009 ,  A61M2025/0096

摘要： The invention relates to an apparatus and method for imaging and mapping various structures located at a target area within a patient's lumen using conventional IVUS technology. The mapped images are used to accurately determine and control the location of the device within the lumen relative to the target area and/or target site. Once the drug delivery device is properly positioned within the lumen, additional ultrasonic images are generated and used to control the position and depth of penetration of a retractable needle of the device. Needle position can be precisely determined, both in relationship to the device as well as the target site for drug delivery. This allows accurate delivery of drug to the target site and, thus, enhanced treatment capabilities.

公开(公告)号：US07867169B2

公开(公告)日：2011-01-11

申请号：US11293420

申请日：2005-12-02

申请人： William E. Webler ,  Mina Chow

发明人： William E. Webler ,  Mina Chow

IPC分类号： A61B8/14

CPC分类号： A61M25/0068 ,  A61B8/0841 ,  A61B90/36 ,  A61B2090/3782 ,  A61M25/0009 ,  A61M25/0045 ,  A61M25/0052 ,  A61M25/0069 ,  A61M25/0084 ,  A61M25/0108 ,  A61M25/0147 ,  A61M2025/0089

摘要： An echogenic medical device, such as a needle catheter, which produces an improved ultrasonic image of the device, and a method of performing a medical procedure using a device of the invention. One aspect is directed to a catheter which reduces artifacts in the ultrasound image of the catheter. In one embodiment, the catheter has a spherical distal tip. Another aspect of the invention is directed to an echogenic catheter with echogenic portions arranged in an array to facilitate determination by ultrasonic imaging of the rotational orientation of the catheter relative to a desired location within the patient.

摘要翻译： 产生设备的改进的超声波图像的回声医疗装置，例如针导管，以及使用本发明的装置执行医疗程序的方法。 一个方面涉及导管，其减少导管的超声图像中的伪像。 在一个实施例中，导管具有球形远端尖端。 本发明的另一方面涉及一种具有排列成阵列的回声部分的回声导管，以有助于通过超声波成像来确定导管相对于患者内的期望位置的旋转取向。

公开(公告)号：US20080041516A1

公开(公告)日：2008-02-21

申请号：US11923258

申请日：2007-10-24

申请人： Jessica Chiu ,  Gregory Chan ,  Gabriel Asongwe ,  Robert Esselstein ,  Douglas Gesswein ,  Srinivasan Sridharan ,  Nianjiong Bei ,  William Webler ,  Stephen Schaible ,  Mina Chow ,  Yan Shen ,  Hongzhi Bai ,  Mark Bly ,  Thomas Hatten

发明人： Jessica Chiu ,  Gregory Chan ,  Gabriel Asongwe ,  Robert Esselstein ,  Douglas Gesswein ,  Srinivasan Sridharan ,  Nianjiong Bei ,  William Webler ,  Stephen Schaible ,  Mina Chow ,  Yan Shen ,  Hongzhi Bai ,  Mark Bly ,  Thomas Hatten

IPC分类号： B29C53/60

CPC分类号： A61M25/10 ,  A61M25/1002 ,  A61M2025/1052

摘要： Embodiments include an infusion-occlusion system having a delivery catheter, a guide catheter adapted to receive the delivery catheter, and a guidewire with an occlusion device adapted to be received within the guide catheter. The guide catheter of the catheter kit may be provided with an occlusion device at the distal end of the guide catheter. The delivery catheter may have an accessory lumen, coaxial or co-linear lumen, a supporting mandrel, or an occlusion device at its distal end. Moreover, according to some embodiments, occlusion devices may be a single material or a composite balloon having an inner liner and an outer layer of different materials, a high compliance low pressure balloon, or a filter device that restricts particles from passing through but does not restrict fluid, such as blood. An inflation device with a large volume and low volume syringe can be used to inflate the balloon.

摘要翻译： 实施例包括具有输送导管的输液阻塞系统，适于接收输送导管的引导导管，以及具有适于容纳在引导导管内的闭塞装置的导丝。 导管套件的引导导管可以在引导导管的远端处设置有闭塞装置。 输送导管可以具有附件腔，同轴或共线腔，支撑心轴或其远端处的闭塞装置。 此外，根据一些实施例，闭塞装置可以是具有内衬和不同材料外层的单一材料或复合球囊，高顺应性低压气球或限制颗粒通过但不限制的过滤装置 限制流体，如血液。 可以使用具有大体积和低体积注射器的充气装置来使气囊膨胀。

公开(公告)号：US20060265043A1

公开(公告)日：2006-11-23

申请号：US11388355

申请日：2006-03-24

申请人： Evgenia Mandrusov ,  Deborah Kilpatrick ,  Murthy Simhambhatla ,  Syed Hossainy ,  Jessica Chiu ,  Mina Chow ,  Eugene Michal ,  Charles Claude ,  William Webler

发明人： Evgenia Mandrusov ,  Deborah Kilpatrick ,  Murthy Simhambhatla ,  Syed Hossainy ,  Jessica Chiu ,  Mina Chow ,  Eugene Michal ,  Charles Claude ,  William Webler

IPC分类号： A61F2/06

CPC分类号： A61F2/07 ,  A61B5/02007 ,  A61B2017/22077 ,  A61F2/82 ,  A61F2/86 ,  A61F2/90 ,  A61F2/958 ,  A61F2002/077 ,  A61F2220/0058 ,  A61F2250/0067 ,  A61M1/3613 ,  A61M25/104 ,  A61M2025/105 ,  A61M2025/1056 ,  A61M2025/107 ,  A61M2025/1086 ,  A61M2025/1095

摘要： Various apparatuses and methods are described to treat vulnerable plaque with the use of combination drug therapy. In one embodiment, the apparatus has an elongated catheter body adapted for insertion in a body lumen, with a drug delivery device attached near a distal portion of the elongated body. The drug delivery device is configured to deliver a therapeutic or biologically active agent to stabilize a vulnerable plaque. In another embodiment, a drug eluting stent is delivered and deployed in conjunction with a second apparatus that delivers drug in pressurized retrograde perfusion. Still another embodiment uses a uniquely shaped balloon to deploy a stent while utilizing a drug infusion needle to inject drug into the vessel wall through a hollow guide wire.

摘要翻译： 描述了使用组合药物治疗来治疗易损斑块的各种装置和方法。 在一个实施例中，该装置具有适于插入体腔中的细长导管体，其中药物递送装置附接在细长体的远侧部分附近。 药物递送装置被配置为递送治疗或生物活性剂以稳定易损斑块。 在另一个实施方案中，药物洗脱支架与在加压逆行灌注中递送药物的第二装置一起递送和展开。 另一个实施例使用独特形状的气囊来展开支架，同时利用药物输注针将药物通过空心导丝将药物注入血管壁。

公开(公告)号：US20050015048A1

公开(公告)日：2005-01-20

申请号：US10800323

申请日：2004-03-11

申请人： Jessica Chiu ,  Gregory Chan ,  Gabriel Asongwe ,  Robert Esselstein ,  Douglas Gesswein ,  Srinivasan Sridharan ,  Nianjiong Bei ,  William Webler ,  Stephen Schaible ,  Mina Chow ,  Yan Shen ,  Hongzhi Bai ,  Mark Bly ,  Thomas Hatten

发明人： Jessica Chiu ,  Gregory Chan ,  Gabriel Asongwe ,  Robert Esselstein ,  Douglas Gesswein ,  Srinivasan Sridharan ,  Nianjiong Bei ,  William Webler ,  Stephen Schaible ,  Mina Chow ,  Yan Shen ,  Hongzhi Bai ,  Mark Bly ,  Thomas Hatten

IPC分类号： A61F2/958 ,  A61M29/00

CPC分类号： A61M25/10 ,  A61M25/1002 ,  A61M2025/1052

摘要： Embodiments include an infusion-occlusion system having a delivery catheter, a guide catheter adapted to receive the delivery catheter, and a guidewire with an occlusion device adapted to be received within the guide catheter. The guide catheter of the catheter kit may be provided with an occlusion device at the distal end of the guide catheter. The delivery catheter may have an accessory lumen, coaxial and/or co-linear lumen, a supporting mandrel, and/or an occlusion device at its distal end. Moreover, according to embodiments, occlusion devices may be a single material or a composite balloon having an inner liner and an outer layer of different materials, a high compliance low pressure balloon, and/or a filter device that restricts particles from passing through but does not restrict fluid, such as blood. An inflation device with a large volume and low volume syringe can be used to inflate the balloon.

摘要翻译： 实施例包括具有输送导管的输液阻塞系统，适于接收输送导管的引导导管，以及具有适于容纳在引导导管内的闭塞装置的导丝。 导管套件的引导导管可以在引导导管的远端处设置有闭塞装置。 输送导管可以在其远端具有附属腔，同轴和/或共线的腔，支撑心轴和/或闭塞装置。 此外，根据实施例，闭塞装置可以是具有不同材料的内衬和外层的单一材料或复合球囊，高顺应性低压气球和/或限制颗粒通过而过滤装置 不限制流体，如血液。 可以使用具有大体积和低体积注射器的充气装置来使气囊膨胀。

公开(公告)号：US06692466B1

公开(公告)日：2004-02-17

申请号：US09746498

申请日：2000-12-21

申请人： Mina Chow ,  Paul John Kawula ,  Jeffrey Steward

发明人： Mina Chow ,  Paul John Kawula ,  Jeffrey Steward

IPC分类号： A61M5178

CPC分类号： A61M25/0084 ,  A61M25/10 ,  A61M2025/0086 ,  A61M2025/0087 ,  A61M2025/009

摘要： A catheter assembly having a balloon disposed at the distal end thereof and a therapeutic substance delivery assembly, including a needle in fluid communication with a therapeutic substance delivery lumen for allowing a therapeutic substance to be injected into a diseased physiological lumen. A deflector is positioned along an inside wall of the delivery lumen, positioned, such that as a bend region forms caused by the movement of the delivery lumen, the deflector bends to rest on the outside curvature of the bend. As the needle is made to travel through the bend, the ribbon helps to bounce the needle tip off the wall of the delivery lumen, allowing the needle to travel through the bend without digging into and/or gouging the delivery lumen wall.

摘要翻译： 一种具有设置在其远端处的气囊的导管组件和包括与治疗物质输送腔流体连通的针的治疗物质输送组件，用于允许将治疗物质注射到患病的生理管腔中。 偏转器沿着输送腔的内壁定位，定位成使得由于由输送腔的运动引起的弯曲区域形成，偏转器弯曲以弯曲的外侧曲率。 当针被制造成穿过弯曲部时，带状物有助于使针尖从输送腔的壁反弹，从而允许针穿过弯曲部而不会进入和/或凿出输送腔壁。

公开(公告)号：US08118803B1

公开(公告)日：2012-02-21

申请号：US11613145

申请日：2006-12-19

申请人： Mina Chow

发明人： Mina Chow

IPC分类号： A61M25/00

CPC分类号： A61M25/0147 ,  A61B18/1492 ,  A61B18/24 ,  A61B2018/00363 ,  A61B2090/3966 ,  A61M25/0053 ,  A61M25/0084 ,  A61M25/0152 ,  A61M25/1002 ,  A61M25/1011 ,  A61M2025/0004 ,  A61M2025/0081 ,  A61M2025/0089

摘要： A deflectable catheter assembly and methods of use are herein disclosed. The catheter assembly, in one embodiment, is deflectable and includes a first catheter, a second catheter, and a third catheter. The second catheter fits coaxially within the first catheter. In some embodiments, the first and/or second catheter can be constituently different from proximal end to distal end. At least one of the first catheter and the second catheter include a deflectable portion to allow deflection of that catheter from a first position to a second position. The third catheter has a sheath and a medical instrument positioned within the sheath. The third catheter fits coaxially within the second catheter.

摘要翻译： 本文公开了可偏转的导管组件和使用方法。 在一个实施例中，导管组件是可偏转的并且包括第一导管，第二导管和第三导管。 第二导管同轴地配合在第一导管内。 在一些实施例中，第一和/或第二导管可以是从近端到远端的选择性区别。 第一导管和第二导管中的至少一个包括可偏转部分，以允许该导管从第一位置偏转到第二位置。 第三导管具有护套和位于护套内的医疗器械。 第三导管同轴地配合在第二导管内。

公开(公告)号：US07887661B2

公开(公告)日：2011-02-15

申请号：US11923258

申请日：2007-10-24

申请人： Jessica G. Chiu ,  Gregory Waimong Chan ,  Gabriel Asongwe ,  Robert C. Esselstein ,  Douglas Gesswein ,  Srinivasan Sridharan ,  Nianjiong Joan Bei ,  William E. Webler ,  Stephen G. Schaible ,  Mina Chow ,  Yan Shen ,  Hongzhi Bai ,  Mark J. Bly ,  Thomas R. Hatten

发明人： Jessica G. Chiu ,  Gregory Waimong Chan ,  Gabriel Asongwe ,  Robert C. Esselstein ,  Douglas Gesswein ,  Srinivasan Sridharan ,  Nianjiong Joan Bei ,  William E. Webler ,  Stephen G. Schaible ,  Mina Chow ,  Yan Shen ,  Hongzhi Bai ,  Mark J. Bly ,  Thomas R. Hatten

IPC分类号： B32B37/00

CPC分类号： A61M25/10 ,  A61M25/1002 ,  A61M2025/1052

摘要： Embodiments include an infusion-occlusion system having a delivery catheter, a guide catheter adapted to receive the delivery catheter, and a guidewire with an occlusion device adapted to be received within the guide catheter. The guide catheter of the catheter kit may be provided with an occlusion device at the distal end of the guide catheter. The delivery catheter may have an accessory lumen, coaxial or co-linear lumen, a supporting mandrel, or an occlusion device at its distal end. Moreover, according to some embodiments, occlusion devices may be a single material or a composite balloon having an inner liner and an outer layer of different materials, a high compliance low pressure balloon, or a filter device that restricts particles from passing through but does not restrict fluid, such as blood. An inflation device with a large volume and low volume syringe can be used to inflate the balloon.

摘要翻译： 实施例包括具有输送导管的输液阻塞系统，适于接收输送导管的引导导管，以及具有适于容纳在引导导管内的闭塞装置的导丝。 导管套件的引导导管可以在引导导管的远端处设置有闭塞装置。 输送导管可以具有附件腔，同轴或共线腔，支撑心轴或其远端处的闭塞装置。 此外，根据一些实施例，闭塞装置可以是具有内衬和不同材料外层的单一材料或复合球囊，高顺应性低压气球或限制颗粒通过但不限制的过滤装置 限制流体，如血液。 可以使用具有大体积和低体积注射器的充气装置来使气囊膨胀。

公开(公告)号：US20090157162A1

公开(公告)日：2009-06-18

申请号：US12253757

申请日：2008-10-17

申请人： Mina Chow ,  William Jason Fox ,  Gregory W. Chan ,  William E. Webler, JR.

发明人： Mina Chow ,  William Jason Fox ,  Gregory W. Chan ,  William E. Webler, JR.

IPC分类号： A61F2/06 ,  A61M25/00

CPC分类号： A61F2/95 ,  A61F2/966 ,  A61F2002/9517 ,  A61F2250/0098 ,  A61M25/0045 ,  A61M25/005 ,  A61M25/0051 ,  A61M25/0133

摘要： A delivery system for delivery of a medical device, the delivery system having an inner member having a proximal section, a distal section and a longitudinal axis therebetween, and an outer member disposed about the inner member, wherein the distal section of the inner member includes at least two wires wound about the inner member.

摘要翻译： 用于输送医疗装置的输送系统，所述输送系统具有内部构件，所述内部构件具有近侧部分，远侧部分和其间的纵向轴线以及围绕所述内部构件设置的外部构件，其中所述内部构件的远端部分包括 至少两根缠绕在内部构件上的电线。

公开(公告)号：US20090018498A1

公开(公告)日：2009-01-15

申请号：US11923411

申请日：2007-10-24

申请人： Jessica G. Chiu ,  Gregory Waimong Chan ,  Gabriel Asongwe ,  Robert C. Esselstein ,  Douglas Gesswein ,  Srinivasan Sridharan ,  Nianjiong Joan Bei ,  William E. Webler ,  Stephen G. Schaible ,  Mina Chow ,  Yan Shen ,  Hongzhi Bai ,  Mark J. Bly ,  Thomas R. Hatten

发明人： Jessica G. Chiu ,  Gregory Waimong Chan ,  Gabriel Asongwe ,  Robert C. Esselstein ,  Douglas Gesswein ,  Srinivasan Sridharan ,  Nianjiong Joan Bei ,  William E. Webler ,  Stephen G. Schaible ,  Mina Chow ,  Yan Shen ,  Hongzhi Bai ,  Mark J. Bly ,  Thomas R. Hatten

IPC分类号： A61M29/02

CPC分类号： A61M25/10 ,  A61M25/1002 ,  A61M2025/1052

摘要： Embodiments include an infusion-occlusion system having a delivery catheter, a guide catheter adapted to receive the delivery catheter, and a guidewire with an occlusion device adapted to be received within the guide catheter. The guide catheter of the catheter kit may be provided with an occlusion device at the distal end of the guide catheter. The delivery catheter may have an accessory lumen, coaxial or co-linear lumen, a supporting mandrel, or an occlusion device at its distal end. Moreover, according to some embodiments, occlusion devices may be a single material or a composite balloon having an inner liner and an outer layer of different materials, a high compliance low pressure balloon, or a filter device that restricts particles from passing through but does not restrict fluid, such as blood. An inflation device with a large volume and low volume syringe can be used to inflate the balloon.