公开(公告)号：US4490295A

公开(公告)日：1984-12-25

申请号：US147584

申请日：1980-05-07

Applicant: Ian D. Fleming ,  David Noble ,  Hazel M. Noble (formerly Gillett) ,  Wilfred F. Wall

Inventor： Ian D. Fleming ,  David Noble ,  Hazel M. Noble (formerly Gillett) ,  Wilfred F. Wall

IPC: C07D503/00 ,  C12P17/18 ,  C07D498/04 ,  A61K31/42

CPC classification number: C07D503/00 ,  C12P17/188

Abstract: The invention provides the compound (2R,5R,Z)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo-[3,2,0]heptane-2-carboxylic acid and its salts in purified form and pharmaceutical compositions containing them and a process for the purification of such compounds by conversion in aqueous media to the lithium salt of the above acid and precipitation thereof.

Abstract translation: 本发明提供化合物（2R，5R，Z）-3-（2-羟基亚乙基）-7-氧代-4-氧杂-1-氮杂双环[3,2,0]庚烷-2-羧酸及其盐 纯化形式和含有它们的药物组合物，以及通过在水性介质中转化为上述酸的锂盐和其沉淀来纯化这些化合物的方法。

公开(公告)号：US4490294A

公开(公告)日：1984-12-25

申请号：US888496

申请日：1978-03-20

Applicant: Ian D. Fleming ,  David Noble ,  Hazel M. Noble ,  Wilfred F. Wall

Inventor： Ian D. Fleming ,  David Noble ,  Hazel M. Noble ,  Wilfred F. Wall

IPC: C07D503/00 ,  C12P17/18 ,  C07D498/04 ,  A61K31/42

CPC classification number: C07D503/00 ,  C12P17/188

Abstract: The invention provides the compound (2R,5R,Z)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo-[3,2,0]-heptane-2-carboxylic acid and its salts in purified form and pharmaceutical compositions containing them and a process for the purification of such compounds by conversion in aqueous media to the lithium salt of the above acid and precipitation thereof.

Abstract translation: 本发明提供化合物（2R，5R，Z）-3-（2-羟基亚乙基）-7-氧代-4-氧杂-1-氮杂双环[3,2,0] - 庚烷-2-羧酸及其 纯化形式的盐和含有它们的药物组合物，以及通过在水性介质中转化为上述酸的锂盐和其沉淀来纯化这些化合物的方法。

公开(公告)号：US4189181A

公开(公告)日：1980-02-19

申请号：US899605

申请日：1978-04-24

Applicant: David Noble ,  Donald Noble

Inventor： David Noble ,  Donald Noble

IPC: A47C4/54 ,  A47C27/08 ,  A47C5/00

CPC classification number: A47C4/54 ,  A47C27/085 ,  Y10S297/03

Abstract: A chair is provided having a seating portion containing a water-filled container formed of a thin flexible film and having a horizontally disposed upper flat surface for the supportive cushioning of the user, and an upright portion having an assembly of 5 to 20 elongated water-filled enclosures disposed in parallel horizontal juxtaposition. The elongated enclosures have a rounded outer contour which provides cushioning to the user's back. The hydrostatic pressure within each elongated water-filled enclosure is between 1" and 4" of water.

Abstract translation: 提供了一种椅子，其具有一个座位部分，该座位部分包含由薄的柔性膜形成的充满水的容器，并且具有水平设置的用于使用者的支撑性缓冲的上部平坦表面，以及具有5至20个细长的水 - 并排放置的并排并置的外壳。 细长的外壳具有圆形的外轮廓，其向使用者的背部提供缓冲。 每个细长的充满水的外壳内的静水压力在1“和4”之间。

公开(公告)号：US08881332B2

公开(公告)日：2014-11-11

申请号：US12101446

申请日：2008-04-11

Applicant: Lise W. Noble ,  Patrick T. Noble

Inventor： Lise W. Noble ,  Patrick T. Noble

IPC: A47L13/22 ,  A45B11/00 ,  A46B15/00 ,  A46B9/02 ,  A46B11/00 ,  A46B17/06

CPC classification number: A46B11/0003 ,  A46B9/025 ,  A46B11/0006 ,  A46B11/0068 ,  A46B15/0002 ,  A46B15/0008 ,  A46B15/0036 ,  A46B17/06 ,  A46B2200/1066 ,  A61C19/063

Abstract: A toothbrush includes a brush head having a capsule receiving zone sized to receive an dentrifice capsule, and a plurality of angled bristles adapted to retain the capsule in such zone. Loading of such toothbrush with a capsule may be performed with a dispenser including a toothbrush manipulation element adapted to move a retention structure associated with the brush head, and dispensation element adapted to deliver the capsule into the receiving zone. Such dispenser may include a desiccant material disposed to receive moisture from a capsule storage container. A dispenser may further include a plurality of toothbrush insertion apertures each adapted to receive a portion of a different toothbrush, so as to enable multiple users each having different toothbrushes to use the same dispenser without requiring contact between multiple brushes and single capsule interface surface of the dispenser.

Abstract translation: 牙刷包括具有胶囊接收区域的刷头，其尺寸被设计成容纳牙齿胶囊，以及适于将胶囊保持在该区域中的多个成角度的刷毛。 用胶囊装载这样的牙刷可以用包括适于移动与刷头相关联的保持结构的牙刷操作元件的分配器以及适于将胶囊输送到接收区域中的分配元件进行。 这种分配器可以包括设置成从胶囊储存容器接收水分的干燥剂材料。 分配器还可以包括多个牙刷插入孔，每个牙刷插入孔适于容纳不同牙刷的一部分，以便能够使具有不同牙刷的多个使用者能够使用相同的分配器，而不需要多个刷子和单个胶囊接口表面之间的接触 分配器

公开(公告)号：US20120224358A1

公开(公告)日：2012-09-06

申请号：US13346692

申请日：2012-01-09

Applicant: Barry A. Noble ,  Fergus M. Noble ,  Robin Liang

Inventor： Barry A. Noble ,  Fergus M. Noble ,  Robin Liang

IPC: F21L4/00 ,  F21V31/00

CPC classification number: F21L4/027 ,  F21S10/00 ,  F21V23/0407 ,  F21V23/0414 ,  F21Y2115/10 ,  G06F8/61 ,  H05B33/0803 ,  H05B33/0842

Abstract: A flashlight having a control unit with a push button for activating the flashlight. The control unit connects to a computer via an USB port, whereby user-configurable control information is downloaded. A computer program running on the computer enables operating conditions of the flashlight to be selected by a user according to predetermined types of activation, e.g., of the push button. The operating conditions are collated into operating instructions associated with the predetermined types of activation. The operating instructions are converted into byte code and downloaded to and stored on a memory in the control unit. Upon detecting a predetermined activation type, the control unit accesses the operating conditions and configures the flashlight accordingly.

Abstract translation: 手电筒具有带有用于激活手电筒的按钮的控制单元。 控制单元通过USB端口连接到计算机，由此下载用户可配置的控制信息。 在计算机上运行的计算机程序使得用户可以根据例如按钮的预定类型的激活来选择手电筒的操作条件。 将操作条件整理为与预定类型的激活相关联的操作说明。 操作指令被转换成字节码并下载到存储在控制单元中的存储器上。 在检测到预定的激活类型时，控制单元访问操作条件并相应地配置手电筒。

公开(公告)号：US20080272714A1

公开(公告)日：2008-11-06

申请号：US12102402

申请日：2008-04-14

Applicant: Barry Angus Noble ,  Fergus McPherson Noble

Inventor： Barry Angus Noble ,  Fergus McPherson Noble

IPC: H05B37/02

CPC classification number: F21V23/0414 ,  F21L4/027 ,  F21S10/00 ,  F21V23/0407 ,  F21Y2115/10 ,  G06F8/61 ,  H05B33/0803 ,  H05B33/0842

Abstract: A flashlight (1) having a control unit (4) with a push button (12) for activating the flashlight (1). The control unit (4) connects to a computer via USB port, whereby user-configurable control information is downloaded. A computer program running on the computer enables operating conditions of the flashlight to be selected by a user according to predetermined types of activation e.g. of the push button (12). The operating conditions are collated into operating instructions associated with the predetermined types of activation. The operating instructions are converted into byte code and downloaded to and stored on a memory in the control unit (4). Upon detecting a predetermined activation type, the control unit accesses the operating conditions and configures the flashlight accordingly.

Abstract translation: 一种具有控制单元（4）的手电筒（1），其具有用于启动手电筒（1）的按钮（12）。 控制单元（4）通过USB端口连接到计算机，从而下载用户可配置的控制信息。 在计算机上运行的计算机程序使得用户可以根据预定类型的激活来选择手电筒的操作条件，例如， 的按钮（12）。 将操作条件整理为与预定类型的激活相关联的操作说明。 操作指令被转换成字节代码并被下载到并存储在控制单元（4）中的存储器上。 在检测到预定的激活类型时，控制单元访问操作条件并相应地配置手电筒。

公开(公告)号：US5784723A

公开(公告)日：1998-07-28

申请号：US692845

申请日：1996-08-02

Applicant: Rhonda W. Noble ,  Edward J. Noble, Jr.

Inventor： Rhonda W. Noble ,  Edward J. Noble, Jr.

IPC: A41C1/00 ,  A41D7/00 ,  A41B9/00 ,  A41B9/02

CPC classification number: A41D7/005 ,  A41C1/003 ,  A41D2300/33 ,  A41D2400/38

Abstract: A figure enhancing garment, which outlines and defines a wearer's body contours in a comfortable manner, includes a pair of pants having first and second pant leg portions, a front panel portion, and a waistband with a tunnel formed therein. The first and second pant leg portions are attached to the front panel portion via first and second interconnected tunnel seams that extend divergently from the crotch area and interconnect with the waistband tunnel. A third tunnel seam interconnects with the first and second tunnel seams and the waistband tunnel while extending upwardly from the crotch portion to the waistband. An adjustable pulley system extends through the waistband tunnel and the first, second and third tunnel seams to adjust the fit of the figure enhancing garment. Alternatively, the first and second seams are simple seams without tunnels. A pair of drawstrings anchored in the crotch portion of the pants, extend upwardly through the tunnel of the third seam and divergently through the tunnel in the waistband to adjust the fit of the figure enhancing garment.

Abstract translation: 包括具有第一和第二裤脚部分的一对裤子，前面板部分和形成有隧道的腰带的一条裤子，其以轮廓舒适的方式概述并限定了穿着者的身体轮廓。 第一和第二短裤腿部经由第一和第二相互连接的隧道接缝连接到前面板部分，其从裆部区域分开延伸并与腰带隧道互连。 第三隧道缝与第一和第二隧道缝和腰带隧道相互连接，同时从裆部向上延伸到腰带。 可调式滑轮系统延伸通过腰带隧道和第一，第二和第三隧道接缝以调节图形增强服装的配合。 或者，第一和第二接缝是没有隧道的简单接缝。 锚定在裤子的裤裆部分的一条束带向上延伸穿过第三缝的隧道并且分散地穿过腰带中的隧道，以调节图形增强服装的配合。

公开(公告)号：US5755611A

公开(公告)日：1998-05-26

申请号：US777157

申请日：1996-12-26

Applicant: Cecil Noble ,  Dora Noble

Inventor： Cecil Noble ,  Dora Noble

IPC: A41C3/06

CPC classification number: A41C3/065

Abstract: A breast support device including a soft, natural breast-shape cup portion for receiving a portion of the breast and a flat, peripheral flange portion which may be secured to the body of the wearer immediately beneath the breast by adhesive tape and renewer adhesive to permit the device to be worn repeatedly.

Abstract translation: 一种乳房支撑装置，包括用于容纳乳房的一部分的柔软的天然乳房杯部分和平坦的周边凸缘部分，其可以通过胶带和更新的粘合剂紧固在乳房下方的身体身上，以允许 该装置要反复穿。

公开(公告)号：US5336789A

公开(公告)日：1994-08-09

申请号：US936222

申请日：1992-08-27

Applicant: Derek R. Sutherland ,  Michael V. J. Ramsay ,  Edward P. Tiley ,  John B. Ward ,  Neil Porter ,  Hazel M. Noble ,  Richard A. Fletton ,  David Noble ,  Brian M. Bain

Inventor： Derek R. Sutherland ,  Michael V. J. Ramsay ,  Edward P. Tiley ,  John B. Ward ,  Neil Porter ,  Hazel M. Noble ,  Richard A. Fletton ,  David Noble ,  Brian M. Bain

IPC: A01N43/90 ,  C07H19/01 ,  C07D313/00

CPC classification number: C07H19/01 ,  A01N43/90

Abstract: Compounds of formula (I) ##STR1## and salts thereof wherein R.sup.1 is a methyl, ethyl or isopropyl group;R.sup.2 is a hydrogen atom or a group OR.sup.4 (where OR.sup.4 is a hydroxyl group or a substituted hydroxyl group having up to 25 carbon atoms) and R.sup.3 is a hydrogen atom, or (when R.sup.2 is a hydrogen atom) a bromine atom; or R.sup.2 and R.sup.3 together with the carbon atom to which they are attached represent >C.dbd.CH.sub.2, >C.dbd.O or >C.dbd.NOR.sup.5 (where R.sup.5 is a hydrogen atom, a C.sub.1-8 alkyl group or a C.sub.3-8 alkenyl group and the group >C.dbd.NOR.sup.5 is in the E configuration); andY represents an oxygen atom or a group NOR.sup.5 (where R.sup.5 is as defined above); with the proviso that when Y is an oxygen atom and R.sup.1 is an isopropyl group, then R.sup.2 is other than hydroxyl group.These compounds may be used for controlling insect, acarine, nematode or other pests.

Abstract translation: 式（I）化合物其中R 1是甲基，乙基或异丙基; R2是氢原子或基团OR4（其中OR4是羟基或具有至多25个碳原子的取代羟基），R3是氢原子，或（当R2是氢原子时）溴原子; 或R 2和R 3与它们所连接的碳原子一起代表C = CH 2，C = O或> C = NOR 5（其中R 5是氢原子，C 1-8烷基或C 3-8烯基 并且组> C = NOR5在E配置中）; Y表示氧原子或基团NOR5（其中R5如上定义）; 条件是当Y是氧原子且R 1是异丙基时，则R 2不是羟基。 这些化合物可用于控制昆虫，螨虫，线虫或其他害虫。

公开(公告)号：US5034542A

公开(公告)日：1991-07-23

申请号：US363765

申请日：1989-06-09

Applicant: Michael V. J. Ramsay ,  Derek R. Sutherland ,  John B. Ward ,  Neil Porter ,  Hazel M. Noble ,  Richard A. Fletton ,  David Noble

Inventor： Michael V. J. Ramsay ,  Derek R. Sutherland ,  John B. Ward ,  Neil Porter ,  Hazel M. Noble ,  Richard A. Fletton ,  David Noble

IPC: C07D493/22 ,  C07H19/01

CPC classification number: C07H19/01

Abstract: A process for the preparation of a compound of formula (I) ##STR1## (in which R.sup.1 is methyl, ethyl or isopropyl) by hydrogenation of a corresponding compound having a double bond at the 22,23-position, for example in the presence of a rhodium catalyst.