公开(公告)号：US5861284A

公开(公告)日：1999-01-19

申请号：US835231

申请日：1997-04-07

Applicant: Osamu Nishimura ,  Masato Kuriyama ,  Nobuyuki Koyama ,  Tsunehiko Fukuda

Inventor： Osamu Nishimura ,  Masato Kuriyama ,  Nobuyuki Koyama ,  Tsunehiko Fukuda

IPC: C07K5/097 ,  C07K14/50 ,  C07K14/605 ,  C07K14/635 ,  C12N15/16 ,  C12N15/62 ,  C12P21/06 ,  C12P21/02

CPC classification number: C07K5/0823 ,  C07K14/503 ,  C07K14/605 ,  C07K14/635 ,  C12N15/62 ,  C12P21/06 ,  C07K2319/00 ,  C07K2319/41 ,  C07K2319/735 ,  C07K2319/75

Abstract: A cysteine-free peptide is produced by producing a fused protein comprising a protein having cysteine at its N-terminal and a cysteine-free peptide ligated to the N-terminal and subsequently subjecting the fused protein to a reaction for cleaving the peptide linkage.

Abstract translation: 通过产生包含其N-末端具有半胱氨酸的蛋白质和与N-末端连接的无半胱氨酸肽并随后使融合蛋白质进行裂解肽键的反应的融合蛋白质来产生半胱氨酸肽。

公开(公告)号：US4368150A

公开(公告)日：1983-01-11

申请号：US233641

申请日：1981-02-11

Applicant: Masahiko Fujino ,  Osamu Nishimura

Inventor： Masahiko Fujino ,  Osamu Nishimura

IPC: C07K1/06 ,  C07K7/23 ,  C07C103/52 ,  C07C147/13

CPC classification number: C07K1/064 ,  C07K7/23

Abstract: A guanidino group in an amino acid or a peptide can be protected with a specific group, i.e. pentamethylbenzensulfonyl, 2,4,6-trimethoxybenzenesulfonyl, 4-methoxy-2,3,5,6-tetramethylbenzenesulfonyl, 4-methoxy-2,6-dimethylbenzenesulfonyl or 4-methoxy-2,3,6-trimethylbenzenesulfonyl, and said group may easily be removed without affecting the amino acid or the peptide to be derived from the protected amino acid or peptide. Thus, the present invention is useful in the synthesis of peptides containing the guanidino group.

Abstract translation: 氨基酸或肽中的胍基可以用特定的基团来保护，即五甲基苯磺酰基，2,4,6-三甲氧基苯磺酰基，4-甲氧基-2,3,5,6-四甲基苯磺酰基，4-甲氧基-2,6 二甲基苯磺酰基或4-甲氧基-2,3,6-三甲基苯磺酰基，并且所述基团可以容易地除去而不影响衍生自被保护的氨基酸或肽的氨基酸或肽。 因此，本发明可用于合成含有胍基的肽。

公开(公告)号：US4229438A

公开(公告)日：1980-10-21

申请号：US36988

申请日：1979-05-07

Applicant: Masahiko Fujino ,  Osamu Nishimura ,  Muneo Takaoki

Inventor： Masahiko Fujino ,  Osamu Nishimura ,  Muneo Takaoki

IPC: A61K38/00 ,  A61K38/22 ,  A61P37/00 ,  C07K5/06 ,  C07K5/083 ,  C07K5/103 ,  C07K7/06 ,  A61K37/00 ,  C07C103/52

CPC classification number: C07K7/06 ,  C07K5/06069 ,  C07K5/081 ,  C07K5/1013 ,  A61K38/00 ,  Y02P20/55 ,  Y10S514/885 ,  Y10S930/18

Abstract: Novel nonapeptides of the formula:pGlu-X-Lys-Ser-Gln-Y-Z-Ser-Asn-OHwherein X is Ala or (D)-Ala; Y and Z are the same or different and each is the residue of a D-amino acid containing 3 to 9 carbon atoms, or Gly; and at least one of X, Y and Z is the residue of D-amino acid, have immunoregulator activity and are of value as medicines.

Abstract translation: 新的具有下列通式的肽：pGlu-X-Lys-Ser-Gln-Y-Z-Ser-Asn-OH其中X是Ala或（D）-Ala; Y和Z相同或不同，分别为含有3〜9个碳原子的D-氨基酸或Gly; X，Y和Z中的至少一个是D-氨基酸的残基，具有免疫调节剂活性，作为药物有价值。

公开(公告)号：US4100152A

公开(公告)日：1978-07-11

申请号：US778321

申请日：1977-03-16

Applicant: Masahiko Fujino ,  Osamu Nishimura ,  Yuji Nagawa ,  Naohisa Fukuda

Inventor： Masahiko Fujino ,  Osamu Nishimura ,  Yuji Nagawa ,  Naohisa Fukuda

IPC: C07K14/575 ,  A61K38/04 ,  A61P5/00 ,  A61P25/26 ,  C07D279/12 ,  C07D307/33 ,  C07K5/06 ,  C07K5/097 ,  C07C103/52 ,  A61K37/00

CPC classification number: C07D307/33 ,  C07D279/12 ,  C07K5/0821

Abstract: A novel peptide of the formula: ##STR1## wherein A is hydrogen, alkyl, aralkyl, alkoxyalkyl, hydroxyalkyl or alkoxy; R is ##STR2## X is --S-- or --(CH.sub.2).sub.n -- where n is 1 or 2 has a weaker TRH releasing activity than TRH and a stronger anaesthesia-antagonistic activity, spontaneous movement-stimulant activity or dopamine-potentiating activity than TRH.

Abstract translation: 一种下式的新肽：其中A是氢，烷基，芳烷基，烷氧基烷基，羟基烷基或烷氧基; R是X - 为-S-或 - （CH2）n-，其中n为1或2具有比TRH更弱的TRH释放活性和更强的麻醉 - 拮抗活性，自发运动刺激活性或多巴胺增强活性， TRH。

公开(公告)号：US09167836B2

公开(公告)日：2015-10-27

申请号：US12445301

申请日：2007-10-01

Applicant: Noriaki Kobayashi ,  Kenji Kumazawa ,  Osamu Nishimura ,  Yasumichi Mizota

Inventor： Noriaki Kobayashi ,  Kenji Kumazawa ,  Osamu Nishimura ,  Yasumichi Mizota

IPC: A23C9/152 ,  A23L1/226 ,  A21D2/28 ,  A23C9/156 ,  A23C11/00 ,  A23D7/005 ,  A23D9/007 ,  A23L2/56

CPC classification number: A23L1/22671 ,  A21D2/28 ,  A23C9/156 ,  A23C11/00 ,  A23D7/0053 ,  A23D7/0056 ,  A23D9/007 ,  A23L2/56 ,  A23L27/2052 ,  A23L27/206

Abstract: There is provided a flavor composition that can impart and augment the natural, fresh and milk-rich feeling of dairy products to a necessary and sufficient level, which is a flavor composition for milk, dairy products, foods or beverages containing milk and dairy products, or dairy product substitutes, characterized by containing a trace amount of one or more disulfide compounds selected from the group consisting of methyl 2-methyl-3-furyl disulfide, bis(2-methyl-3-furyl)disulfide, methyl furfuryl disulfide and difurfuryl disulfide, as dairy products to which the flavor composition is added.

Abstract translation: 提供了一种风味组合物，其可以赋予和增加乳制品的天然，新鲜和富乳的感觉到必要和足够的水平，其是用于牛奶，乳制品，含有乳和乳制品的食品或饮料的风味组合物， 特征在于含有微量的一种或多种二硫化物，其选自2-甲基-3-呋喃基二硫化物，双（2-甲基-3-呋喃基）二硫化物，甲基糠基二硫化物和二氟化糠基 二硫化物，作为添加了风味组合物的乳制品。

公开(公告)号：US09088854B2

公开(公告)日：2015-07-21

申请号：US13428055

申请日：2012-03-23

Applicant: Akihiko Enamito ,  Osamu Nishimura ,  Takahiro Hiruma

Inventor： Akihiko Enamito ,  Osamu Nishimura ,  Takahiro Hiruma

IPC: H04R5/00 ,  H04S1/00

CPC classification number: H04S7/302 ,  H04S1/002 ,  H04S2420/01

Abstract: According to an embodiment, a control filter coefficient is calculated in such a manner that a second spatial average of one or more complex sound pressure ratios at one or more target binaural positions when a first loudspeaker and a second loudspeaker emit a second acoustic signal and a first acoustic signal is approximated to a first spatial average of one or more complex sound pressure ratios at the one or more target binaural positions when a target virtual acoustic source emits the first acoustic signal.

Abstract translation: 根据一个实施例，控制滤波器系数被计算为当第一扬声器和第二扬声器发射第二声信号时在一个或多个目标双耳位置处的一个或多个复合声压比的第二空间平均值， 当目标虚拟声源发射第一声信号时，第一声信号近似于一个或多个目标双耳位置处的一个或多个复合声压比的第一空间平均值。

公开(公告)号：US20130065258A1

公开(公告)日：2013-03-14

申请号：US13699592

申请日：2011-01-28

Applicant: Makoto Watanabe ,  Ei-ichi Matsuo ,  Naoki Kaneko ,  Toshiya Matsubara ,  Osamu Nishimura ,  Masaki Mori ,  Ichiro Takemasa

Inventor： Makoto Watanabe ,  Ei-ichi Matsuo ,  Naoki Kaneko ,  Toshiya Matsubara ,  Osamu Nishimura ,  Masaki Mori ,  Ichiro Takemasa

IPC: G01N33/574 ,  C07K14/47 ,  G01N21/64

CPC classification number: G01N33/57419 ,  G01N2333/4724

Abstract: The present invention provides a tumor screening marker that can be actually used in clinical practice to detect colorectal cancer, and a tumor progression marker that can complement CEA or CA19-9. Galectin-1 used as a tumor screening marker or a tumor progression marker for colorectal cancer. Galectin-3 used as a tumor screening marker. Galectin-4 used as a tumor progression marker, a tumor screening marker, or a prognostic prediction marker for colorectal cancer. A method of analyzing the galectin concentration in a collected blood sample using the galectin. A colorectal cancer marker detection kit comprising a detection antibody selected from the group consisting of a fluorescently labeled galectin-1 antibody, a fluorescently labeled galectin-3 antibody, and a fluorescently labeled galectin-4 antibody.

Abstract translation: 本发明提供可以实际用于临床实践中检测结肠直肠癌的肿瘤筛选标记，以及可补充CEA或CA19-9的肿瘤进展标记。 Galectin-1用作肿瘤筛选标记物或肿瘤进展标志物用于结肠直肠癌。 Galectin-3用作肿瘤筛选标记。 用作肿瘤进展标记物的Galectin-4，肿瘤筛选标记或结肠直肠癌的预后预测标记物。 使用半乳凝素分析收集的血液样品中的半乳凝素浓度的方法。 一种包含选自荧光标记的半乳凝素-1抗体，荧光标记的半乳凝素-3抗体和荧光标记的半乳凝素-4抗体的检测抗体的结肠直肠癌标志物检测试剂盒。

公开(公告)号：US20120149026A1

公开(公告)日：2012-06-14

申请号：US13370840

申请日：2012-02-10

Applicant: Toshiya Matsubara ,  Osamu Nishimura ,  Susumu Iwasa ,  Makoto Watanabe

Inventor： Toshiya Matsubara ,  Osamu Nishimura ,  Susumu Iwasa ,  Makoto Watanabe

IPC: C12Q1/68 ,  G01N33/53 ,  C07K16/18 ,  C07H21/04 ,  C12Q1/37 ,  G01N33/566

CPC classification number: C07K14/52 ,  C07K14/475 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/68 ,  G01N2500/04 ,  G01N2500/10 ,  G01N2800/042

Abstract: It is provided an insulin resistance marker, a method of evaluating insulin resistance, a method of screening a substance that improves insulin resistance, and a pharmaceutical composition for improving insulin resistance. An insulin resistance marker including a polypeptide comprising at least any 15 continuous amino acids in the specific amino acid sequence (sequence of a proepithelin protein). An insulin resistance marker including a polynucleotide selected from the group consisting of a polynucleotide comprising at least any 45 continuous bases in the base sequence encoding the above specific amino acid sequence, and a polynucleotide that is complementary to the polynucleotide.

Abstract translation: 本发明提供胰岛素抵抗标记，胰岛素抵抗评价方法，筛选改善胰岛素抵抗的物质的方法以及改善胰岛素抵抗的药物组合物。 包括在特定氨基酸序列（前列腺素蛋白的序列）中包含至少15个连续氨基酸的多肽的胰岛素抵抗标记。 包括选自包含编码上述特定氨基酸序列的碱基序列中至少任何45个连续碱基的多核苷酸的多核苷酸的多核苷酸和与该多核苷酸互补的多核苷酸的胰岛素抵抗标记。

公开(公告)号：US07804224B2

公开(公告)日：2010-09-28

申请号：US12039319

申请日：2008-02-28

Applicant: Hiroshi Takahashi ,  Osamu Nishimura ,  Toshikatsu Akiba

Inventor： Hiroshi Takahashi ,  Osamu Nishimura ,  Toshikatsu Akiba

IPC: H02N2/10

CPC classification number: H02N2/108 ,  H02N2/0025 ,  H02N2/0055 ,  H02N2/103

Abstract: A piezoelectric motor includes: a plurality of piezoelectric units, respectively in contact with a driven target, disposed separately from each other, and configured to drive the driven target; and a magnet configured to apply a preload force to each of the plurality of piezoelectric units by magnetically attracting the driven target in the absence of direct contact with the driven target.

Abstract translation: 一种压电电动机包括：分别与被驱动目标接触的多个压电单元，彼此分离设置并构造成驱动所述被驱动目标; 以及磁体，其构造成通过在不与被驱动目标件直接接触的情况下磁吸引所述被驱动目标而对所述多个压电单元中的每一个施加预加载力。

公开(公告)号：US20090191575A1

公开(公告)日：2009-07-30

申请号：US12303363

申请日：2007-06-05

Applicant: Makoto Watanabe ,  Osamu Nishimura ,  Toshiya Matsubara ,  Ichiro Takemasa ,  Morito Monden ,  Katsuya Nagai ,  Nariaki Matsuura

Inventor： Makoto Watanabe ,  Osamu Nishimura ,  Toshiya Matsubara ,  Ichiro Takemasa ,  Morito Monden ,  Katsuya Nagai ,  Nariaki Matsuura

IPC: G01N33/574 ,  C12N9/12 ,  C12N9/24 ,  C07K14/00 ,  C12N9/10 ,  C12N9/14 ,  C12N9/50 ,  C12N9/02 ,  G01N33/573

CPC classification number: G01N33/57419

Abstract: The present invention provides a tumor marker and a method capable of identifying the morbidity of colon cancer. A tumor marker including a protein identified from a colon cancer tissue. A method for identify the morbidity of colon cancer using the tumor marker. The method includes: measuring the level of the protein in a sample derived from a person of interest who should be examined to identify the morbidity of colon cancer; and comparing the measured level to the normal level of the protein, wherein a higher or lower measured level than the normal level is used as one indicator indicating that there is a high possibility that the person of interest has colon cancer.

Abstract translation: 本发明提供了能够鉴定结肠癌发病率的肿瘤标志物和方法。 包括从结肠癌组织鉴定的蛋白质的肿瘤标志物。 使用肿瘤标志物鉴定结肠癌发病率的方法。 该方法包括：测量衍生自感兴趣的人的样品中蛋白质的水平，其应当被检查以鉴定结肠癌的发病率; 并且将测量的水平与蛋白质的正常水平进行比较，其中使用比正常水平更高或更低的测量水平作为一个指标，指示感兴趣的人具有结肠癌的可能性很高。