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公开(公告)号：US20120221065A1
公开(公告)日：2012-08-30
申请号：US13461539
申请日：2012-05-01
IPC分类号： A61N1/08
CPC分类号： A61N1/08 , A61N2001/083
摘要： A method, system, and apparatus for performing a lead condition assessment and/or a lead orientation determination associated with an implantable medical device (IMD). A first impedance is determined. The first impedance relates to the impedance relative to a first electrode and a portion of the IMD. A second impedance is determined. The second impedance relates to the impedance relative to a second electrode and the portion of the IMD. The first impedance is compared with the second impedance to determine an impedance difference. A determination is made whether the impedance difference is outside a predetermined tolerance range. Furthermore, artifact measured during impedance measurements or test pulses may be compared to assess lead orientation. An indication of a lead condition error is provided in response to determining that the impedance difference is outside the predetermined tolerance range.
摘要翻译： 一种用于执行与可植入医疗装置（IMD）相关联的引导条件评估和/或引导方向确定的方法，系统和装置。 确定第一阻抗。 第一阻抗涉及相对于第一电极和IMD的一部分的阻抗。 确定第二阻抗。 第二阻抗涉及相对于第二电极和IMD的部分的阻抗。 将第一阻抗与第二阻抗进行比较以确定阻抗差。 确定阻抗差是否在预定的公差范围之外。 此外，可以比较阻抗测量或测试脉冲期间测量的伪像，以评估引线方向。 响应于确定阻抗差在预定公差范围之外，提供引导条件错误的指示。
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公开(公告)号：US07974688B2
公开(公告)日：2011-07-05
申请号：US12189743
申请日：2008-08-11
IPC分类号： A61N1/08
CPC分类号： A61N1/36135 , A61N1/37211
摘要： A method sensing at least two physiological parameters and, for each of the at least two physiological parameters, generating a first series of signals representative of the physiological parameter sensed over a first time period, storing each of said first series of signals as a time sequence data stream, and determining when a physiological event has occurred in a patient. The method further comprises analyzing each of said time sequence data streams for a predetermined time interval preceding the occurrence of a physiological event to determine at least one marker as a predictor of the event, and again sensing the physiological parameters. Furthermore, the method comprises generating a second series of signals representative of the physiological parameter sensed, analyzing each of the second series of signals to determine whether the marker is present, and stimulating a cranial nerve when the marker is present in the second series of signals.
摘要翻译： 一种感测至少两个生理参数的方法，并且对于所述至少两个生理参数中的每一个，产生表示在第一时间段内感测的生理参数的第一序列信号，将所述第一系列信号中的每一个存储为时间序列 数据流，以及确定患者何时发生生理事件。 该方法还包括在生理事件发生之前的预定时间间隔内分析每个所述时间序列数据流，以将至少一个标记确定为事件的预测因子，并再次感测生理参数。 此外，该方法包括产生代表感测的生理参数的第二系列信号，分析第二系列信号中的每一个以确定标记是否存在，以及当标记存在于第二系列信号中时刺激颅神经 。
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公开(公告)号：US20090270959A1
公开(公告)日：2009-10-29
申请号：US12499001
申请日：2009-07-07
IPC分类号： A61N1/08
CPC分类号： A61N1/08 , A61N2001/083
摘要： A method, system, and apparatus for performing a lead condition assessment and/or a lead orientation determination associated with an implantable medical device (IMD). A first impedance is determined. The first impedance relates to the impedance relative to a first electrode and a portion of the IMD. A second impedance is determined. The second impedance relates to the impedance relative to a second electrode and the portion of the IMD. The first impedance is compared with the second impedance to determine an impedance difference. A determination is made whether the impedance difference is outside a predetermined tolerance range. Furthermore, artifact measured during impedance measurements or test pulses may be compared to assess lead orientation. An indication of a lead condition error is provided in response to determining that the impedance difference is outside the predetermined tolerance range.
摘要翻译： 一种用于执行与可植入医疗装置（IMD）相关联的引导条件评估和/或引导方向确定的方法，系统和装置。 确定第一阻抗。 第一阻抗涉及相对于第一电极和IMD的一部分的阻抗。 确定第二阻抗。 第二阻抗涉及相对于第二电极和IMD的部分的阻抗。 将第一阻抗与第二阻抗进行比较以确定阻抗差。 确定阻抗差是否在预定的公差范围之外。 此外，可以比较阻抗测量或测试脉冲期间测量的伪像，以评估引线方向。 响应于确定阻抗差在预定公差范围之外，提供引导条件错误的指示。
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24.发明申请ALTERNATIVE OPERATION MODE FOR AN IMPLANTABLE MEDICAL DEVICE BASED UPON LEAD CONDITION 有权基于引导条件的可植入医疗设备的替代操作模式公开(公告)号：US20090125079A1
公开(公告)日：2009-05-14
申请号：US11925746
申请日：2007-10-26
IPC分类号： A61N1/32
CPC分类号： A61N1/0551 , A61N1/0558 , A61N1/3605 , A61N1/36082 , A61N2001/083
摘要： The present invention provides for a method, apparatus, and system for determining an adverse operational condition associated with a lead assembly in an implantable medical device used for providing a therapeutic electrical signal to a cranial nerve. A first impedance associated with the lead assembly configured to provide the therapeutic electrical signal to a cranial nerve is detected. A determination is made as to whether the first impedance is outside a first predetermined range of values. A second impedance is detected. The detection of the second impedance is performed within a predetermined period of time from the time of the detection of the first impedance. A determination is made as to whether the second impedance is outside a second predetermined range of values. A determination that a lead condition problem exists is made in response to a determination that the first is outside the first predetermined range of values and second impedance is outside the second predetermined range of values. The implantable medical device is prevented from providing the therapeutic electrical signal to the cranial nerve in response to determining that the lead condition problem exists.
摘要翻译： 本发明提供了一种用于确定与用于向颅神经提供治疗电信号的可植入医疗装置中的引线组件相关联的不利操作状况的方法，装置和系统。 检测与被配置为向颅神经提供治疗电信号的引线组件相关联的第一阻抗。 确定第一阻抗是否在第一预定值范围之外。 检测到第二阻抗。 第二阻抗的检测在从检测到第一阻抗的时刻起的预定时间段内执行。 确定第二阻抗是否在第二预定值范围之外。 响应于第一个超出第一预定值范围的确定并且第二阻抗在第二预定值范围之外，存在导致条件问题的确定。 响应于确定存在铅条件问题，防止可植入医疗装置向颅神经提供治疗电信号。
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公开(公告)号：US20070179548A1
公开(公告)日：2007-08-02
申请号：US11588798
申请日：2006-10-27
IPC分类号： A61N1/00
CPC分类号： A61N1/08 , A61N1/3708 , A61N1/378
摘要： A method and an apparatus for determining a time period remaining in a useful life of an energy storage device in an implantable medical device. The method may include measuring a voltage of the energy storage device to produce a measured voltage, and comparing the measured voltage to a transition voltage. While the measured voltage is greater than or equal to the transition voltage, the time period remaining in the energy storage device's useful life is approximated based upon a function of charge depleted. While the measured voltage is less than the transition voltage, the time period remaining in the energy storage device's useful life is approximated based upon a higher order polynomial function of the measured voltage. The transition voltage corresponds to a predetermined point on a energy storage device voltage depletion curve representing the voltage across the energy storage device over time.
摘要翻译： 一种用于确定可植入医疗装置中的能量存储装置的使用寿命中剩余的时间段的方法和装置。 该方法可以包括测量能量存储装置的电压以产生测量的电压，并将测量的电压与转换电压进行比较。 当测量的电压大于或等于转换电压时，能量存储器件的使用寿命中剩余的时间段基于电荷耗尽的函数近似。 当测量的电压小于转换电压时，能量存储器件的使用寿命中剩余的时间段基于所测量的电压的较高阶多项式函数近似。 转换电压对应于表示能量存储装置上的电压随时间的电压耗尽曲线上的预定点。
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公开(公告)号：US5456699A
公开(公告)日：1995-10-10
申请号：US163880
申请日：1993-12-08
CPC分类号： A61N1/05
摘要： A lead insertion tool for use with an implantable cardiac stimulator having a connector receptacle and for use with an associated lead having a connector pin for insertion within the connector receptacle. The tool includes spring biased jaws for gripping the lead at a location set back from the terminus of the connector pin. An insertion stop is connected to the jaw for engaging the cardiac stimulator to limit the depth of insertion of the connector pin within the connector receptacle. An integral depth gauge extends from the gripping jaws toward the terminus of the connector pin for gauging the location of the insertion stop relative to the terminus of the connector pin. Full insertion of the connector pin within the connector receptacle is assured when the insertion stop engages the cardiac stimulator. The depth gauge is hinged to the gripping jaws and can move out of the way as the connector pin is inserted into the connector receptacle.
摘要翻译： 一种用于具有连接器插座的可植入心脏刺激器的引导插入工具，并且用于具有用于插入连接器插座内的连接器针的相关联的引线。 该工具包括用于在从连接器销的端部设置的位置处夹持引线的弹簧偏压钳口。 插入止动件连接到钳口以接合心脏刺激器以限制连接器插头在连接器插座内的插入深度。 整体深度计从夹爪延伸到连接器针的末端，用于测量插入止动件相对于连接器销的端部的位置。 当插入止动器接合心脏刺激器时，确保连接器插头在连接器插座内完全插入。 深度计铰接到夹爪上，当连接器插头插入连接器插座时，可以将其移开。
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公开(公告)号：US4776206A
公开(公告)日：1988-10-11
申请号：US84264
申请日：1987-08-11
CPC分类号： G01M3/3254
摘要： To leak test a cavity in a test item, a pressurizing gas, at a preselected pressure is applied to the test item and the flow rate of the pressurizing gas during pressurization is recorded. This recorded flow rate is compared with a threshold level based on gas flow signature data for a reference test item. If the recorded gas flow exceeds the threshold level, an excessive leak signal is produced. This leak testing method significantly reduces the time required to perform low flow rate leak detection in large volume test items.
摘要翻译： 为了对测试项目中的空腔进行泄漏测试，将加压气体以预选压力施加到测试项目，并记录加压期间加压气体的流量。 将该记录的流量与基于参考测试项目的气体流动特征数据的阈值水平进行比较。 如果记录的气体流量超过阈值水平，则产生过度的泄漏信号。 这种泄漏测试方法大大减少了在大容量测试项目中执行低流量泄漏检测所需的时间。
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28.发明授权Alternative operation mode for an implantable medical device based upon lead condition 有权基于导线条件的可植入医疗器械的替代操作模式公开(公告)号：US08942798B2
公开(公告)日：2015-01-27
申请号：US11925746
申请日：2007-10-26
CPC分类号： A61N1/0551 , A61N1/0558 , A61N1/3605 , A61N1/36082 , A61N2001/083
摘要： A method, apparatus, and system for determining an adverse operational condition associated with a lead assembly in an implantable medical device used for providing a therapeutic electrical signal to a cranial nerve. A first impedance associated with the lead assembly configured to provide the therapeutic electrical signal to a cranial nerve is detected. A determination is made as to whether the first impedance is outside a first predetermined range. A second impedance is detected. The detection of the second impedance is performed within a predetermined period of time from the time of the detection of the first impedance. A determination is made as to whether the second impedance is outside a second predetermined range. If the first impedance is outside the first range and the second impedance is outside the second range, the implantable medical device is prevented from providing the therapeutic electrical signal.
摘要翻译： 一种用于确定与用于向颅神经提供治疗电信号的可植入医疗装置中的引线组件相关联的不利操作状况的方法，装置和系统。 检测与被配置为向颅神经提供治疗电信号的引线组件相关联的第一阻抗。 确定第一阻抗是否在第一预定范围之外。 检测到第二阻抗。 第二阻抗的检测在从检测到第一阻抗的时刻起的预定时间段内进行。 确定第二阻抗是否在第二预定范围之外。 如果第一阻抗在第一范围之外且第二阻抗在第二范围之外，则可以防止可植入医疗装置提供治疗电信号。
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29.发明授权Implantable medical device having multiple electrode/sensor capability and stimulation based on sensed intrinsic activity 有权具有多个电极/传感器能力和基于感测到的内在活动的刺激的植入式医疗装置公开(公告)号：US08600521B2
公开(公告)日：2013-12-03
申请号：US11045602
申请日：2005-01-27
IPC分类号： A61N1/36
CPC分类号： A61N1/36139 , A61B5/05 , A61B5/4094 , A61N1/36071 , A61N1/36082 , A61N1/36114
摘要： In one embodiment, an implantable neurostimulator comprises a pulse generator that generates an electrical pulse signal to stimulate a neural structure in a patient, a stimulation lead assembly coupled to the pulse generator for delivering the electrical pulse signal to the neural structure, a plurality of sensors coupled to the pulse generator, and sensor select logic. Each sensor is individually selectable and the sensor select logic selects any two or more of the plurality of sensors for sensing a voltage difference between the selected sensors. In other embodiments, two or more physiologic parameters are sensed. In yet another embodiment, a method comprises sensing intrinsic electrical activity on a person's nerve and stimulating the nerve based on the sensed intrinsic electrical activity of the nerve.
摘要翻译： 在一个实施例中，可植入神经刺激器包括产生电脉冲信号以刺激患者中的神经结构的脉冲发生器，耦合到脉冲发生器的刺激引线组件，用于将电脉冲信号传递到神经结构，多个传感器 耦合到脉冲发生器和传感器选择逻辑。 每个传感器可单独选择，传感器选择逻辑选择多个传感器中的任何两个或多个传感器，用于感测所选传感器之间的电压差。 在其他实施例中，感测到两个或更多生理参数。 在另一个实施例中，一种方法包括基于感测到的神经内在电活动来感测人的神经上的固有电活动并刺激神经。
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公开(公告)号：US08565881B2
公开(公告)日：2013-10-22
申请号：US12820841
申请日：2010-06-22
IPC分类号： A61N1/00
CPC分类号： A61N1/08 , A61N1/3708 , A61N1/378
摘要： A method and an apparatus for projecting an end of service (EOS) and/or an elective replacement indication (ERI) of a component in an implantable device is provided. The method comprises measuring the measured voltage of the energy storage device, and determining whether the measured voltage is less than a transition voltage. When the measured voltage is less than the transition voltage, determining a time period remaining until an end of service of the energy storage device is based upon a function of the measured voltage. When the measured voltage is greater than or equal to the transition voltage, determining a time period remaining until an end of service of the energy storage device is based upon a function of the total charge depleted. The transition voltage is a voltage associated with the transition point of non-linearity in the battery voltage depletion curve.
摘要翻译： 提供了一种用于在可植入装置中投射组件的服务结束（EOS）和/或选择性替换指示（ERI）的方法和装置。 该方法包括测量能量存储装置的测量电压，以及确定测得的电压是否小于转换电压。 当测量的电压小于转换电压时，确定剩余的能量储存装置的使用时间是基于所测量的电压的函数。 当测量的电压大于或等于转换电压时，确定能量存储装置的使用结束之前剩余的时间是基于耗尽的总电荷的函数。 转换电压是与电池电压耗尽曲线中的非线性转变点相关的电压。
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