公开(公告)号：US5681433A

公开(公告)日：1997-10-28

申请号：US307355

申请日：1994-09-14

Applicant: Dwayne T. Friesen ,  David D. Newbold ,  Scott B. McCray ,  Roderick J. Ray

Inventor： Dwayne T. Friesen ,  David D. Newbold ,  Scott B. McCray ,  Roderick J. Ray

IPC: B01D61/36 ,  B01D53/22 ,  B01D53/26 ,  B01D3/00 ,  B01D19/00

CPC classification number: B01D53/268 ,  B01D53/22 ,  B01D53/229 ,  B01D61/36 ,  Y10S159/27 ,  Y10S203/17

Abstract: A process for the dehydration of a vaporous mixture. The basic process involves directing a predominantly condensable water vapor-containing vaporous mixture against the feed side of a membrane while maintaining the feed near saturation without condensing it, directing a condensable vapor sweep stream past the permeate side of the membrane in a countercurrent flow, thereby transporting water vapor in the vaporous mixture from the feed side to the permeate side of the membrane to form a noncondensed combined permeate side mixture of condensable vapor and transported water vapor.

Abstract translation: 蒸汽混合物脱水的方法。 基本方法包括将主要是可冷凝的含水蒸汽混合物引导到膜的进料侧，同时保持进料接近饱和而不使其冷凝，引导可冷凝的蒸汽吹扫流以逆流流过膜的渗透侧，由此 将蒸汽混合物中的水蒸气从进料侧输送到膜的渗透侧，以形成可冷凝蒸汽和输送的水蒸气的非冷凝的组合渗透侧混合物。

公开(公告)号：US5611842A

公开(公告)日：1997-03-18

申请号：US583309

申请日：1996-01-05

Applicant: Dwayne T. Friesen ,  David D. Newbold ,  Scott B. McCray ,  Roderick J. Ray

Inventor： Dwayne T. Friesen ,  David D. Newbold ,  Scott B. McCray ,  Roderick J. Ray

IPC: B01D61/36 ,  B01D53/22

CPC classification number: B01D53/229 ,  B01D53/22

Abstract: A process for the removal of at least one non-water vapor component of a vaporous mixture, the basic process comprising directing a vaporous mixture against the feed side of a membrane, directing a condensable vapor sweep stream past the permeate side of the membrane in a manner such that the flow of the condensable vapor sweep is substantially countercurrent to the flow of the vaporous mixture, thereby transporting at least a portion of at least one non-water vapor component of the vaporous mixture from the feed side to the permeate side of the membrane to form a combined permeate side mixture of condensable vapor and at least one non-water vapor transported component.

Abstract translation: 一种用于去除气态混合物的至少一种非水蒸汽组分的方法，所述基本方法包括将蒸汽混合物引导到膜的进料侧，引导可冷凝的蒸气吹扫流通过膜的渗透侧 使得可冷凝蒸汽吹扫的流动基本上与气态混合物的流动逆流，从而将至少一部分蒸汽混合物的非水蒸汽组分从进料侧输送到蒸发混合物的渗透侧 膜以形成可冷凝蒸气和至少一种非水蒸汽输送组分的组合的渗透侧混合物。

公开(公告)号：US07951403B2

公开(公告)日：2011-05-31

申请号：US11003659

申请日：2004-12-03

Applicant: Dwayne T. Friesen ,  Marshall D. Crew ,  Roderick J. Ray ,  Leah E. Appel

Inventor： Dwayne T. Friesen ,  Marshall D. Crew ,  Roderick J. Ray ,  Leah E. Appel

IPC: A61K9/14 ,  A61K9/16

CPC classification number: A61K9/1617 ,  A61K9/1635 ,  A61K9/1694 ,  A61K31/7052

Abstract: A process for forming drug multiparticulates having improved drug crystallinity is disclosed, comprising modifying a conventional melt-congeal process by adding a volatile cospecies either to the molten mixture or to the process atmosphere, or to both.

Abstract translation: 公开了一种形成具有改善的药物结晶度的药物多颗粒的方法，其包括通过向熔融混合物或加工气氛或两者添加挥发性环氧树脂来改变常规的熔融 - 凝结过程。

公开(公告)号：US07780988B2

公开(公告)日：2010-08-24

申请号：US10351568

申请日：2003-01-24

Applicant: Ronald A. Beyerinck ,  Roderick J. Ray ,  Dan E. Dobry ,  Dana M. Settell

Inventor： Ronald A. Beyerinck ,  Roderick J. Ray ,  Dan E. Dobry ,  Dana M. Settell

IPC: A61K9/14 ,  B29B9/00

CPC classification number: A61K9/1652 ,  A61K9/1694

Abstract: Homogeneous solid amorphous dispersions of drugs in concentration-enhancing polymers are formed in desirable larger particle sizes with minimal fines by using an atomizer and process conditions capable of producing droplets having an average diameter of at least 50 microns and a D10 of at least 10 microns.

Abstract translation: 浓缩增强聚合物中药物的均匀固体无定型分散体通过使用雾化器和能够产生平均直径为至少50微米，D10为至少10微米的液滴的工艺条件，以最小的细粉形成期望的较大粒径。

公开(公告)号：US06763607B2

公开(公告)日：2004-07-20

申请号：US10353746

申请日：2003-01-28

Applicant: Ronald A. Beyerinck ,  Heather L. M. Deibele ,  Dan E. Dobry ,  Roderick J. Ray ,  Dana M. Settell ,  Ken R. Spence

Inventor： Ronald A. Beyerinck ,  Heather L. M. Deibele ,  Dan E. Dobry ,  Roderick J. Ray ,  Dana M. Settell ,  Ken R. Spence

IPC: F26B312

CPC classification number: A61K9/1682 ,  A61J3/02 ,  A61K9/146 ,  A61K9/1652 ,  A61K9/1694 ,  A61K31/404 ,  A61K31/47 ,  B01J2/04

Abstract: Conventional spray-drying methods are improved by incorporation of a pressure nozzle and a diffuser plate to improve the flow of drying gas and a drying chamber extension to increase drying time, such improvements leading to the formation of homogeneous solid dispersions of drugs in concentration-enhancing polymers.