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1.发明授权Method for making homogeneous spray-dried solid amorphous drug dispersions utilizing modified spray-drying apparatus 有权使用改进的喷雾干燥装置制备均匀喷雾干燥的固体无定形药物分散体的方法公开(公告)号：US08343550B2
公开(公告)日：2013-01-01
申请号：US13165732
申请日：2011-06-21
申请人： Ronald A. Beyerinck , Heather L. M. Deibele , Dan E. Dobry , Roderick J. Ray , Dana M. Settell , Ken R. Spence
发明人： Ronald A. Beyerinck , Heather L. M. Deibele , Dan E. Dobry , Roderick J. Ray , Dana M. Settell , Ken R. Spence
CPC分类号： A61K9/1682 , A61J3/02 , A61K9/146 , A61K9/1652 , A61K9/1694 , A61K31/404 , A61K31/47 , B01J2/04
摘要： Conventional spray-drying methods are improved by incorporation of a pressure nozzle and a diffuser plate to improve the flow of drying gas and a drying chamber extension to increase drying time, such improvements leading to the formation of homogeneous solid dispersions of drugs in concentration-enhancing polymers.
摘要翻译： 传统的喷雾干燥方法通过结合压力喷嘴和扩散板来改善干燥气体的流动和干燥室延伸以增加干燥时间，这样的改进导致药物浓度增强的均匀固体分散体形成 聚合物。
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2.发明申请METHOD FOR MAKING HOMOGENEOUS SPRAY-DRIED SOLID AMORPHOUS DRUG DISPERSIONS UTILIZING MODIFIED SPRAY-DRYING APPARATUS 有权使用改性喷雾干燥装置制备均匀喷雾干燥固体非晶态药物分散体的方法公开(公告)号：US20110277339A1
公开(公告)日：2011-11-17
申请号：US13165732
申请日：2011-06-21
申请人： Ronald A. Beyerinck , Heather L. M. Deibele , Dan E. Dobry , Roderick J. Ray , Dana M. Settell , Ken R. Spence
发明人： Ronald A. Beyerinck , Heather L. M. Deibele , Dan E. Dobry , Roderick J. Ray , Dana M. Settell , Ken R. Spence
IPC分类号： F26B3/12
CPC分类号： A61K9/1682 , A61J3/02 , A61K9/146 , A61K9/1652 , A61K9/1694 , A61K31/404 , A61K31/47 , B01J2/04
摘要： Conventional spray-drying methods are improved by incorporation of a pressure nozzle and a diffuser plate to improve the flow of drying gas and a drying chamber extension to increase drying time, such improvements leading to the formation of homogeneous solid dispersions of drugs in concentration-enhancing polymers.
摘要翻译： 传统的喷雾干燥方法通过结合压力喷嘴和扩散板来改善干燥气体的流动和干燥室延伸以增加干燥时间，这样的改进导致药物浓度增强的均匀固体分散体形成 聚合物。
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公开(公告)号：US06763607B2
公开(公告)日：2004-07-20
申请号：US10353746
申请日：2003-01-28
申请人： Ronald A. Beyerinck , Heather L. M. Deibele , Dan E. Dobry , Roderick J. Ray , Dana M. Settell , Ken R. Spence
发明人： Ronald A. Beyerinck , Heather L. M. Deibele , Dan E. Dobry , Roderick J. Ray , Dana M. Settell , Ken R. Spence
IPC分类号： F26B312
CPC分类号： A61K9/1682 , A61J3/02 , A61K9/146 , A61K9/1652 , A61K9/1694 , A61K31/404 , A61K31/47 , B01J2/04
摘要： Conventional spray-drying methods are improved by incorporation of a pressure nozzle and a diffuser plate to improve the flow of drying gas and a drying chamber extension to increase drying time, such improvements leading to the formation of homogeneous solid dispersions of drugs in concentration-enhancing polymers.
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4.发明授权Method for making homogeneous spray-dried solid amorphous drug dispersions utilizing modified spray-drying apparatus 有权使用改进的喷雾干燥装置制备均匀喷雾干燥的固体无定形药物分散体的方法公开(公告)号：US06973741B2
公开(公告)日：2005-12-13
申请号：US10766450
申请日：2004-01-27
申请人： Ronald A. Beyerinck , Heather L. M. Diebele , Dan E. Dobry , Roderick J. Ray , Dana M. Settell , Ken R. Spence
发明人： Ronald A. Beyerinck , Heather L. M. Diebele , Dan E. Dobry , Roderick J. Ray , Dana M. Settell , Ken R. Spence
CPC分类号： A61K9/1682 , A61J3/02 , A61K9/146 , A61K9/1652 , A61K9/1694 , A61K31/404 , A61K31/47 , B01J2/04
摘要： Conventional spray-drying methods are improved by incorporation of a pressure nozzle and a diffuser plate to improve the flow of drying gas and a drying chamber extension to increase drying time, such improvements leading to the formation of homogeneous solid dispersions of drugs in concentration-enhancing polymers.
摘要翻译： 传统的喷雾干燥方法通过结合压力喷嘴和扩散板来改善干燥气体的流动和干燥室延伸以增加干燥时间，这样的改进导致药物浓度增强的均匀固体分散体形成 聚合物。
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5.发明授权Method for making homogeneous spray-dried solid amorphous drug dispersions using pressure nozzles 有权使用压力喷嘴制备均匀喷雾干燥的固体无定形药物分散体的方法公开(公告)号：US07780988B2
公开(公告)日：2010-08-24
申请号：US10351568
申请日：2003-01-24
CPC分类号： A61K9/1652 , A61K9/1694
摘要： Homogeneous solid amorphous dispersions of drugs in concentration-enhancing polymers are formed in desirable larger particle sizes with minimal fines by using an atomizer and process conditions capable of producing droplets having an average diameter of at least 50 microns and a D10 of at least 10 microns.
摘要翻译： 浓缩增强聚合物中药物的均匀固体无定型分散体通过使用雾化器和能够产生平均直径为至少50微米，D10为至少10微米的液滴的工艺条件，以最小的细粉形成期望的较大粒径。
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