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    Countercurrent dehydration by hollow fibers
    5.
    发明授权
    Countercurrent dehydration by hollow fibers 失效
    中空纤维逆流脱水

    公开(公告)号：US5108464A

    公开(公告)日：1992-04-28

    申请号：US673128

    申请日：1991-03-20

    申请人： Dwayne T. Friesen ,  Roderick J. Ray ,  David D. Newbold ,  Scott B. McCray

    发明人： Dwayne T. Friesen ,  Roderick J. Ray ,  David D. Newbold ,  Scott B. McCray

    IPC分类号： B01D53/22 ,  B01D53/26

    CPC分类号： B01D53/22 ,  B01D53/268 ,  B01D63/02 ,  B01D2313/04

    摘要： A gas dehydration method and apparatus are disclosed which utilize lumen-side feed, hydrophilic polymer-inside-coated, thin-film composite hollow fiber membranes, the support fiber of which is highly permeable, such composite membranes being used in a module wherein the permeate flows countercurrent to the flow of the feed, and in which dried raffinate gas is mixed with water-containing permeate at a point opposite the feed end of the module.

    摘要翻译： 公开了一种利用管腔侧进料，亲水聚合物内涂层，薄膜复合中空纤维膜的气体脱水方法和装置，其中载体纤维是高度可渗透的，这种复合膜用于模块中，其中渗透物 与进料的流动逆流流动，其中在与模块的进料端相对的点处将干燥的残液气体与含水渗透物混合。

    Enzymatic membrane method for the synthesis and separation of peptides
    9.
    发明授权
    Enzymatic membrane method for the synthesis and separation of peptides 失效
    用于合成和分离肽的酶膜法

    公开(公告)号：US5350681A

    公开(公告)日：1994-09-27

    申请号：US928673

    申请日：1992-08-12

    申请人： Guillermo A. Iacobucci ,  Daniel J. Brose ,  Roderick J. Ray ,  Paul van Eikeren

    发明人： Guillermo A. Iacobucci ,  Daniel J. Brose ,  Roderick J. Ray ,  Paul van Eikeren

    IPC分类号： C07K1/00 ,  C07K5/072 ,  C07K14/70 ,  C12M1/40 ,  C12P21/02 ,  C12P21/00

    CPC分类号： C07K5/0613 ,  C07K1/00 ,  C07K14/70 ,  C12M21/18 ,  C12P21/02 ,  Y10S530/801

    摘要： The present invention discloses a method for the enzymatic synthesis of a peptide. A protected peptide having a C-terminal carboxylate group or a protected, N-acyl amino acid having an alpha carboxylate group is reacted with a protected peptide having an N-terminal ammonium group or a protected amino acid having an alpha ammonium group in the presence of a condensation enzyme under conditions in which the carboxylate group and the ammonium group condense to form a protected, uncharged, peptide product. This peptide product is transported across a water-immiscible hydrophobic phase into an aqueous product phase and prevented from back diffusing across the water-immiscible hydrophobic phase. The peptide product can be converted, chemically or enzymatically, to a charged species that cannot back diffuse across the water-immiscible phase into the aqueous reaction phase. The water-immiscible hydrophobic phase is an ion rejection membrane separating the aqueous reaction phase from the product phase creating oil/water interfaces with each of the aqueous phases.

    摘要翻译： 本发明公开了一种肽合成酶的方法。 具有羧酸C端的保护肽或具有α羧酸酯基团的被保护的N-酰基氨基酸在存在下与具有N-末端铵基或被保护的氨基酸的受保护肽反应 的缩合酶在羧酸酯基和铵基团缩合形成受保护的不带电荷的肽产物的条件下反应。 该肽产物通过水不混溶的疏水相转运到水相产物相中并防止反向扩散穿过与水不混溶的疏水相。 肽产物可以化学或酶促转化成不能通过水不混溶相扩散到水反应相中的带电物质。 水不混溶的疏水相是将水反应相与产物相分离的离子排斥膜，产生与每个水相的油/水界面。