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1.发明授权Method for making homogeneous spray-dried solid amorphous drug dispersions using pressure nozzles 有权使用压力喷嘴制备均匀喷雾干燥的固体无定形药物分散体的方法公开(公告)号：US07780988B2
公开(公告)日：2010-08-24
申请号：US10351568
申请日：2003-01-24
CPC分类号： A61K9/1652 , A61K9/1694
摘要： Homogeneous solid amorphous dispersions of drugs in concentration-enhancing polymers are formed in desirable larger particle sizes with minimal fines by using an atomizer and process conditions capable of producing droplets having an average diameter of at least 50 microns and a D10 of at least 10 microns.
摘要翻译： 浓缩增强聚合物中药物的均匀固体无定型分散体通过使用雾化器和能够产生平均直径为至少50微米，D10为至少10微米的液滴的工艺条件，以最小的细粉形成期望的较大粒径。
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公开(公告)号：US06763607B2
公开(公告)日：2004-07-20
申请号：US10353746
申请日：2003-01-28
申请人： Ronald A. Beyerinck , Heather L. M. Deibele , Dan E. Dobry , Roderick J. Ray , Dana M. Settell , Ken R. Spence
发明人： Ronald A. Beyerinck , Heather L. M. Deibele , Dan E. Dobry , Roderick J. Ray , Dana M. Settell , Ken R. Spence
IPC分类号： F26B312
CPC分类号： A61K9/1682 , A61J3/02 , A61K9/146 , A61K9/1652 , A61K9/1694 , A61K31/404 , A61K31/47 , B01J2/04
摘要： Conventional spray-drying methods are improved by incorporation of a pressure nozzle and a diffuser plate to improve the flow of drying gas and a drying chamber extension to increase drying time, such improvements leading to the formation of homogeneous solid dispersions of drugs in concentration-enhancing polymers.
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3.发明授权Method for making homogeneous spray-dried solid amorphous drug dispersions utilizing modified spray-drying apparatus 有权使用改进的喷雾干燥装置制备均匀喷雾干燥的固体无定形药物分散体的方法公开(公告)号：US08343550B2
公开(公告)日：2013-01-01
申请号：US13165732
申请日：2011-06-21
申请人： Ronald A. Beyerinck , Heather L. M. Deibele , Dan E. Dobry , Roderick J. Ray , Dana M. Settell , Ken R. Spence
发明人： Ronald A. Beyerinck , Heather L. M. Deibele , Dan E. Dobry , Roderick J. Ray , Dana M. Settell , Ken R. Spence
CPC分类号： A61K9/1682 , A61J3/02 , A61K9/146 , A61K9/1652 , A61K9/1694 , A61K31/404 , A61K31/47 , B01J2/04
摘要： Conventional spray-drying methods are improved by incorporation of a pressure nozzle and a diffuser plate to improve the flow of drying gas and a drying chamber extension to increase drying time, such improvements leading to the formation of homogeneous solid dispersions of drugs in concentration-enhancing polymers.
摘要翻译： 传统的喷雾干燥方法通过结合压力喷嘴和扩散板来改善干燥气体的流动和干燥室延伸以增加干燥时间，这样的改进导致药物浓度增强的均匀固体分散体形成 聚合物。
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4.发明申请METHOD FOR MAKING HOMOGENEOUS SPRAY-DRIED SOLID AMORPHOUS DRUG DISPERSIONS UTILIZING MODIFIED SPRAY-DRYING APPARATUS 有权使用改性喷雾干燥装置制备均匀喷雾干燥固体非晶态药物分散体的方法公开(公告)号：US20110277339A1
公开(公告)日：2011-11-17
申请号：US13165732
申请日：2011-06-21
申请人： Ronald A. Beyerinck , Heather L. M. Deibele , Dan E. Dobry , Roderick J. Ray , Dana M. Settell , Ken R. Spence
发明人： Ronald A. Beyerinck , Heather L. M. Deibele , Dan E. Dobry , Roderick J. Ray , Dana M. Settell , Ken R. Spence
IPC分类号： F26B3/12
CPC分类号： A61K9/1682 , A61J3/02 , A61K9/146 , A61K9/1652 , A61K9/1694 , A61K31/404 , A61K31/47 , B01J2/04
摘要： Conventional spray-drying methods are improved by incorporation of a pressure nozzle and a diffuser plate to improve the flow of drying gas and a drying chamber extension to increase drying time, such improvements leading to the formation of homogeneous solid dispersions of drugs in concentration-enhancing polymers.
摘要翻译： 传统的喷雾干燥方法通过结合压力喷嘴和扩散板来改善干燥气体的流动和干燥室延伸以增加干燥时间，这样的改进导致药物浓度增强的均匀固体分散体形成 聚合物。
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5.发明授权Method for making homogeneous spray-dried solid amorphous drug dispersions utilizing modified spray-drying apparatus 有权使用改进的喷雾干燥装置制备均匀喷雾干燥的固体无定形药物分散体的方法公开(公告)号：US06973741B2
公开(公告)日：2005-12-13
申请号：US10766450
申请日：2004-01-27
申请人： Ronald A. Beyerinck , Heather L. M. Diebele , Dan E. Dobry , Roderick J. Ray , Dana M. Settell , Ken R. Spence
发明人： Ronald A. Beyerinck , Heather L. M. Diebele , Dan E. Dobry , Roderick J. Ray , Dana M. Settell , Ken R. Spence
CPC分类号： A61K9/1682 , A61J3/02 , A61K9/146 , A61K9/1652 , A61K9/1694 , A61K31/404 , A61K31/47 , B01J2/04
摘要： Conventional spray-drying methods are improved by incorporation of a pressure nozzle and a diffuser plate to improve the flow of drying gas and a drying chamber extension to increase drying time, such improvements leading to the formation of homogeneous solid dispersions of drugs in concentration-enhancing polymers.
摘要翻译： 传统的喷雾干燥方法通过结合压力喷嘴和扩散板来改善干燥气体的流动和干燥室延伸以增加干燥时间，这样的改进导致药物浓度增强的均匀固体分散体形成 聚合物。
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公开(公告)号：US09028870B2
公开(公告)日：2015-05-12
申请号：US12979278
申请日：2010-12-27
申请人： Leah E. Appel , Ronald A. Beyerinck , Mark B. Chidlaw , William J. Curatolo , Dwayne T. Friesen , Kelly L. Smith , Avinash G. Thombre
发明人： Leah E. Appel , Ronald A. Beyerinck , Mark B. Chidlaw , William J. Curatolo , Dwayne T. Friesen , Kelly L. Smith , Avinash G. Thombre
IPC分类号： A61K9/00
CPC分类号： A61K9/0004
摘要： A controlled release dosage form has a coated core with the core comprising a drug-containing composition and a water-swellable composition, each occupying separate regions within the core. The drug-containing composition comprises a low-solubility drug and a drug-entraining agent. The coating around the core is water-permeable, water-insoluble and has at least one delivery port therethrough. A variety of formulations having specific drug release profiles are disclosed.
摘要翻译： 控释剂型具有涂覆的核心，其核心包含含药物的组合物和水溶胀性组合物，每个组合物占据核心内的分开的区域。 含药组合物包含低溶解度药物和药物引诱剂。 芯周围的涂层是透水的，不溶于水的，并且具有至少一个通过其的输送口。 公开了具有特定药物释放曲线的多种制剂。
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公开(公告)号：US20110182947A1
公开(公告)日：2011-07-28
申请号：US12979278
申请日：2010-12-27
申请人： Leah E. Appel , Ronald A. Beyerinck , Mark B. Chidlaw , William J. Curatolo , Dwayne T. Friesen , Kelly L. Smith , Avinash G. Thombre
发明人： Leah E. Appel , Ronald A. Beyerinck , Mark B. Chidlaw , William J. Curatolo , Dwayne T. Friesen , Kelly L. Smith , Avinash G. Thombre
IPC分类号： A61K9/00 , A61K31/135 , A61K31/404 , A61P25/24 , A61P29/00 , A61K31/403 , A61K31/496 , A61K31/519 , A61P15/10
CPC分类号： A61K9/0004
摘要： A controlled release dosage form has a coated core with the core comprising a drug-containing composition and a water-swellable composition, each occupying separate regions within the core. The drug-containing composition comprises a low-solubility drug and a drug-entraining agent. The coating around the core is water-permeable, water-insoluble and has at least one delivery port therethrough. A variety of formulations having specific drug release profiles are disclosed.
摘要翻译： 控释剂型具有涂覆的核心，其核心包含含药物的组合物和水溶胀性组合物，每个组合物占据核心内的分开的区域。 含药组合物包含低溶解度药物和药物引诱剂。 芯周围的涂层是透水的，不溶于水的，并且具有至少一个通过其的输送口。 公开了具有特定药物释放曲线的多种制剂。
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公开(公告)号：US06899896B2
公开(公告)日：2005-05-31
申请号：US09745096
申请日：2000-12-20
申请人： William J. Curatolo , Kenneth C. Waterman , Avinash G. Thombre , Michael B. Fergione , Michael C. Roy , Leah A. Appel , Danni Supplee , Dwayne T. Friesen , Mark B. Chidlaw , Ronald A. Beyerinck
发明人： William J. Curatolo , Kenneth C. Waterman , Avinash G. Thombre , Michael B. Fergione , Michael C. Roy , Leah A. Appel , Danni Supplee , Dwayne T. Friesen , Mark B. Chidlaw , Ronald A. Beyerinck
IPC分类号： A61K9/26 , A61K9/00 , A61K9/22 , A61K9/36 , A61K31/135 , A61K47/10 , A61K47/12 , A61K47/26 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61P3/04 , A61P15/00 , A61P15/10 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/30 , A61P43/00 , A61K9/24 , A61K9/32
CPC分类号： A61K9/0004 , A61K31/135 , Y10S514/951
摘要： A controlled release dosage form for sertraline has a core comprising a sertraline-containing composition and a water-swellable composition wherein the water-swellable composition is in a separate region within the core. A coating around the core is water-permeable, water-insoluble, and has at least one delivery port therethrough. In one embodiment, the dosage form releases sertraline to the use environment at an average rate of 6 to 10 wt % per hour from the second to the twenth hour after introduction to a use environment and less than about 25 wt % for the first two hours and at least 70 wt % by the twelfth hour, where the percentages correspond to the mass of drug released from the tablet divided by the total mass of drug originally present in the tablet. In another embodiment, the dosage form releases less than about 25 wt % of sertraline to the use environment by the second hour after introduction of the dosage form to the use environment, and delivers at least 25 wt % from the eighth to the twenty-fourth hour.
摘要翻译： 舍曲林的控制释放剂型具有包含含舍曲林组合物和水溶胀性组合物的核心，其中水溶胀性组合物在核心内的分离区域中。 芯周围的涂层是透水的，不溶于水的，并且具有至少一个通过其的输送口。 在一个实施方案中，剂型在引入使用环境后的第二至第十小时以平均速率以每小时6至10重量％的平均速率释放到使用环境，并且在前两小时内小于约25重量％ 和至少70重量％，其中百分比对应于从片剂释放的药物的质量除以最初存在于片剂中的药物的总质量。 在另一个实施方案中，在将剂型引入使用环境后第二小时，剂型释放小于约25重量％的舍曲林至使用环境，并且从第八至第二十四至第十二 小时。
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