公开(公告)号：US11724017B2

公开(公告)日：2023-08-15

申请号：US17520840

申请日：2021-11-08

Applicant: SHIBUYA CORPORATION

Inventor： Kosho Matsuzaki ,  Takashi Mishima

IPC: A61M1/36

CPC classification number: A61M1/3649 ,  A61M1/3647 ,  A61M1/3656 ,  A61M2205/3337

Abstract: A dialysis apparatus has a connection channel that communicatively connects a dialysate circuit and a blood circuit, and circulates dialysate from the dialysate circuit to the blood circuit via the connection channel during a priming operation. A blood pump has a tube attachment device that switches from an unattached state in which a tube is positioned outside a housing and permits liquid to circulate thereinside, to an attached state in which the tube is in the housing and a rotor compresses the tube. At the time of priming, the liquid feeding pump feeds dialysate from the dialysate circuit to the blood circuit via the connection channel. With the blood pump being in the unattached state, the dialysate is circulated past the blood pump, and then, with the blood pump in the attached state, the dialysate is circulated in a direction opposite to the blood pump.

公开(公告)号：US20220287922A1

公开(公告)日：2022-09-15

申请号：US17633405

申请日：2020-07-28

Applicant: NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY ,  SHIBUYA CORPORATION

Inventor： Misako NAKASHIMA ,  Koichiro IOHARA ,  Kenji YONEDA ,  Ryosuke MURAI ,  Hiroyuki NAGAI

IPC: A61K6/884 ,  A61K35/32 ,  A61L27/38

Abstract: A dentin regenerative cell culture that can bring about a rapid regeneration of dentin in a deficit region. In the treatment of a tooth using the dentin regenerative cell culture, a root canal where a pulpectomy has been performed is filled with a root canal filler containing dental pulp stem cells. The dentin regenerative cell culture is then implanted in the deficit region of dentin, and temporary sealing with a packing is carried out. The dentin regenerative cell culture is formed three-dimensionally in conformity with the shape of the deficit region with the coalescence of cell masses of a plurality of odontoblasts, and thus the dentin regeneration is well promoted. In addition, gaps between the dentin regenerative cell culture and biological tissue can be rapidly filled. Infection due to bacterial infiltration can thereby be prevented.

公开(公告)号：US20220112064A1

公开(公告)日：2022-04-14

申请号：US17500945

申请日：2021-10-14

Applicant: SHIBUYA CORPORATION

Inventor： Yasuto NISHIDE ,  Hiroyoshi YAMADA

IPC: B67B3/20

Abstract: A chuck for a capping machine includes a plurality of chuck members, a biasing member configured to bias the plurality of chuck members radially inward, an abutting portion configured to abut against a top face of a cap, and a plurality of chuck jaws provided on an inner surface of each of the plurality of chuck members to engage knurls of the cap. Each of the plurality of chuck jaws includes a leading flank and a trailing flank. An angle of the trailing flank with respect to an outer circumference of the cap is less than an angle of the leading flank with respect to the outer circumference of the cap.

公开(公告)号：US20210403313A1

公开(公告)日：2021-12-30

申请号：US17352804

申请日：2021-06-21

Applicant: SHIBUYA CORPORATION

Inventor： Noriaki NISHIMURA

IPC: B67D7/42 ,  B67D7/02

Abstract: A liquid is efficiently suctioned and discharged from and to a container formed by a plurality of aligned storing portions for storing the liquid, using a plurality of nozzles. Provided is a liquid suction/discharge device including a container support device for supporting a culture container formed by a plurality of aligned storing portions, and a nozzle support device for supporting a plurality of nozzles in a state in which distal ends of the nozzles are directed downward. The nozzle support device includes a nozzle support member that swingably supports the plurality of nozzles using prescribed parts as support points, and the liquid suction/discharge device further includes a nozzle inclination device for causing each of the nozzles to be inclined with respect to the nozzle support member.

公开(公告)号：US11155454B2

公开(公告)日：2021-10-26

申请号：US16750284

申请日：2020-01-23

Applicant: SHIBUYA CORPORATION

Inventor： Masaaki Eda ,  Kazuki Takashima ,  Naoya Washi

IPC: B67C7/00

Abstract: A container processing system includes a filling apparatus and a sterilization apparatus, the filling apparatus including first processing units adapted to process a container held by a gripper at stop positions with a sixth rotating body being rotated while intermittently stopped, the sterilization apparatus including a servomotor adapted to stop the container held by a gripper at an appropriate processing position by driving a second rotating body. During one intermittent motion of the filling apparatus, the sterilization apparatus rotates the gripper of the second rotating body once and thereby moves the gripper from a receiving position for the container to the processing position, stops the gripper there, and then moves the gripper to a transfer position.

公开(公告)号：US20210291083A1

公开(公告)日：2021-09-23

申请号：US17196327

申请日：2021-03-09

Applicant: SHIBUYA CORPORATION

Inventor： Toshiaki NAKA ,  Shigeki KOISHI ,  Akira HATANAKA

IPC: B01D29/56 ,  B01D29/62 ,  B01D61/14

Abstract: A liquid containing exosomes is filtered through a first filter that has a hole diameter that passes the exosomes and blocks cells, and is then stored in a first storage unit (rough filtration step). Next, pressure is applied to the inside of the first storage unit to pump the liquid to a pre-filtration chamber in a second filter that blocks the exosomes so that water in the liquid is filtered out into a post-filtration chamber. The exosome-containing liquid that was not filtered out is returned to the first storage unit, thereby increasing the exosome concentration in the liquid for extraction (concentration step). The exosome-containing concentrate in the first storage unit is then filtered through a third filter having a hole diameter that passes the exosomes and blocks bacteria, and is sent to a recovery unit (sterilization filtration step).

公开(公告)号：US11014798B2

公开(公告)日：2021-05-25

申请号：US16332956

申请日：2017-09-13

Applicant: SHIBUYA CORPORATION

Inventor： Yukinobu Nishino ,  Katsunori Tanikawa ,  Koji Kaya ,  Kengo Ikeda ,  Shigeki Koishi ,  Masaaki Eda

IPC: B67C3/00 ,  B65B3/04 ,  B67C7/00 ,  B67C3/02

Abstract: A filling system includes a center wheel that conveys vessels, a first filler provided with a plurality of filling heads, a second filler provided with a plurality of filling heads and arranged downstream from the first filler, a first inlet wheel that receives the vessels from the center wheel and supplies the vessels to the first filler, and a second inlet wheel that receives the vessel from the center wheel and supplies the vessels to the second filler. Operation modes are switchable between a first operation mode that conveys the vessels to the first filler and a second operation mode that conveys the vessels to the second filler instead of conveying to the first filler by controlling the reception of the vessels at the first and second inlet wheels.

公开(公告)号：US10746725B2

公开(公告)日：2020-08-18

申请号：US16019695

申请日：2018-06-27

Applicant: SHINSHU UNIVERSITY ,  KAIJO CORPORATION ,  SHIBUYA CORPORATION

Inventor： Jiye Jin ,  Nobuyuki Kurashina ,  Junichiro Soejima ,  Toshiharu Sawada

IPC: G01N33/49 ,  G01N33/579 ,  G01N27/327 ,  A61M1/34 ,  B01D61/24 ,  C02F1/44

Abstract: Endotoxin is detected by electrochemical measurement. A detection device 15 of endotoxin detects endotoxin contained in a fluid to be tested (for example, a dialysate) specifically in the following manner. First, the fluid to be tested is brought into contact with an adsorbent 17 that adsorbs endotoxin to cause the adsorbent 17 to adsorb the endotoxin. Then, a basic solution is brought into contact with the adsorbent 17 to desorb the endotoxin. Electrochemical measurement of the basic solution containing the desorbed endotoxin is performed. The endotoxin can be detected by the electrochemical measurement with high sensitivity at low cost.

公开(公告)号：US20200255275A1

公开(公告)日：2020-08-13

申请号：US16750284

申请日：2020-01-23

Applicant: SHIBUYA CORPORATION

Inventor： Masaaki EDA ,  Kazuki TAKASHIMA ,  Naoya WASHI

IPC: B67C7/00

Abstract: A container processing system includes a filling apparatus and a sterilization apparatus, the filling apparatus including first processing units adapted to process a container held by a gripper at stop positions with a sixth rotating body being rotated while intermittently stopped, the sterilization apparatus including a servomotor adapted to stop the container held by a gripper at an appropriate processing position by driving a second rotating body. During one intermittent motion of the filling apparatus, the sterilization apparatus rotates the gripper of the second rotating body once and thereby moves the gripper from a receiving position for the container to the processing position, stops the gripper there, and then moves the gripper to a transfer position.

公开(公告)号：US20200002661A1

公开(公告)日：2020-01-02

申请号：US16455068

申请日：2019-06-27

Applicant: SHIBUYA CORPORATION

Inventor： Toru KESYOU ,  Daisuke WATANABE ,  Tomohiro KONISHI

IPC: C12M1/00

Abstract: There is provided a cell observation apparatus having a sterile chamber 3 containing a culture vessel 1 and a transparent observation window 11 provided in a bottom portion of the sterile chamber 3 and having the culture vessel 1 placed thereabove, wherein the camera 4 and the lighting 5 are provided below the observation window 11. The cells in the culture vessel 1 are imaged through the observation window 11 by setting the focus of the camera 4 to a bottom surface 1d of the culture vessel 1. The lighting 5 emits inspection light L as spot light where the light is not diffused, and an imaging range of the camera 4 is positioned inside an irradiation range of the inspection light L on the bottom surface 1d of the culture vessel 1.