公开(公告)号：US12090446B2

公开(公告)日：2024-09-17

申请号：US17053280

申请日：2019-06-03

申请人： SHINSHU UNIVERSITY ,  LIXIL CORPORATION

发明人： Morinobu Endo ,  Toru Noguchi ,  Hiroyuki Yamada

IPC分类号： B01D69/12 ,  B01D61/02 ,  B01D63/10 ,  B01D67/00 ,  B01D69/02 ,  B01D69/10 ,  B01D71/10 ,  B01D71/56 ,  B32B27/06 ,  B32B27/28 ,  C02F1/44 ,  C02F103/08

CPC分类号： B01D69/1251 ,  B01D61/025 ,  B01D61/026 ,  B01D63/107 ,  B01D67/0006 ,  B01D69/02 ,  B01D69/10 ,  B01D69/125 ,  B01D71/10 ,  B01D71/56 ,  B32B27/06 ,  B32B27/286 ,  C02F1/441 ,  B01D63/10 ,  B01D2313/12 ,  B01D2319/04 ,  B01D2323/30 ,  B01D2325/20 ,  B32B2255/10 ,  B32B2255/26 ,  B32B2262/062 ,  B32B2307/726 ,  C02F2103/08 ,  C02F2303/20

摘要： A semipermeable composite membrane that reduces an environmental load, and a method of producing the semipermeable composite membrane. A semipermeable composite membrane includes, on a porous support, a semipermeable membrane containing a crosslinked polyamide and a cellulose nanofiber. A method of producing the semipermeable composite membrane includes obtaining a mixed solution containing the cellulose nanofiber, water, and an amine component, and obtaining the semipermeable composite membrane by making the mixed solution be in contact with the porous support, thereafter, causing a cross-linking reaction of the amine component in the mixed solution, with the amine component adhering to the porous support.

公开(公告)号：US20240301352A1

公开(公告)日：2024-09-12

申请号：US18653299

申请日：2024-05-02

申请人： AGC INC. ,  KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION ,  SHINSHU UNIVERSITY

发明人： Megumi KISHIMOTO ,  Yuto SHIMIZU ,  Susumu KUBOTA ,  Shigeki YAGYU ,  Masaya SUEMATSU ,  Yozo NAKAZAWA ,  Miyuki TANAKA

IPC分类号： C12N5/0783

CPC分类号： C12N5/0636 ,  C12N2510/00

摘要： The present invention provides a method for producing a chimeric antigen receptor T (CAR-T) cell, including a step of bead separating with a specific factor a T cell from a T cell source, wherein the specific factor is CD45RA+ or the like. The method enables production of CAR-T cells high antitumor property, and can produce highly functional CAR-T cells conveniently in a short time at a low cost.

公开(公告)号：US20240060024A1

公开(公告)日：2024-02-22

申请号：US18259250

申请日：2021-12-23

申请人： SHINSHU UNIVERSITY ,  STELLA CHEMIFA CORPORATION

发明人： Naoto SAITO ,  Takeshi UEMURA ,  Kazutoshi HISANO ,  Yoshinori SATO ,  Masashi YAMAMOTO ,  Keiichi NII ,  Tetsuo NISHIDA

IPC分类号： C12M1/00 ,  C08J7/12

CPC分类号： C12M23/20 ,  C08J7/123

摘要： Provided are a cell culture member having excellent cell culture performance and its long-term stability, and a method for modifying the surface thereof. The cell culture member according to the present invention is a cell culture member having at least a holding region that holds an adherent cell and contains a polymer compound, wherein at least a part of the holding region is a surface-modified region in which a functional group containing a nitrogen atom is directly chemically bonded to a part of carbon atoms and/or silicon atoms constituting the polymer compound, and the present invention can provide a cell culture member that improves adhesiveness of the adherent cell to the surface-modified region, suppresses deterioration over time of adhesiveness, and is excellent in cell culture performance and its long-term stability.

公开(公告)号：US20240052299A1

公开(公告)日：2024-02-15

申请号：US18259237

申请日：2021-12-23

申请人： SHINSHU UNIVERSITY ,  STELLA CHEMIFA CORPORATION

发明人： Naoto SAITO ,  Takeshi UEMURA ,  Kazutoshi HISANO ,  Yoshinori SATO ,  Masashi YAMAMOTO ,  Keiichi NII ,  Tetsuo NISHIDA

IPC分类号： C12N5/00 ,  C12M1/12 ,  C08J7/12

CPC分类号： C12N5/0068 ,  C12M25/04 ,  C08J7/12 ,  C12N2509/00 ,  C12N2533/30 ,  C12N2537/00 ,  C08J2325/06

摘要： Provided are a cell culture member having excellent cell culture performance and its long-term stability, and a method for modifying the surface thereof. The cell culture member according to the present invention is a cell culture member having at least a holding region that holds an adherent cell and contains a polymer compound, wherein at least a part of the holding region is a surface-modified region in which a fluorine atom is directly chemically bonded to a part of carbon atoms and/or silicon atoms constituting the polymer compound, and the present invention can provide a cell culture member that improves adhesiveness of the adherent cell to the surface-modified region, suppresses deterioration over time of adhesiveness, and is excellent in cell culture performance and its long-term stability.

公开(公告)号：US20230295568A1

公开(公告)日：2023-09-21

申请号：US18168135

申请日：2023-02-13

申请人： Shinshu University ,  Kyoto Prefectural Public University Corporation

发明人： Hajime Hosoi ,  Tomoko Iehara ,  Shigeki Yagyu ,  Yozo Nakazawa

IPC分类号： C12N5/0783 ,  C07K14/725 ,  A61P35/00 ,  C07K14/705

CPC分类号： C12N5/0636 ,  C07K14/7051 ,  A61P35/00 ,  C07K14/70521 ,  C12N2510/00 ,  C07K2319/02 ,  C07K2319/03

摘要： An object of the present invention is to provide a therapeutic strategy in the solid tumor area and a means useful therefor to further advance the clinical application of CAR therapy. There is prepared a gene-modified lymphocyte which expresses a chimeric antigen receptor having an EphrinB2 extracellular domain at the antigen recognition site.

公开(公告)号：US20230243855A1

公开(公告)日：2023-08-03

申请号：US17909036

申请日：2021-03-03

申请人： SHINSHU UNIVERSITY

发明人： Tatsuya SAWAMURA ,  Akemi KAKINO

IPC分类号： G01N33/74 ,  G01N33/92 ,  G01N33/68 ,  G01N33/53

CPC分类号： G01N33/74 ,  G01N33/92 ,  G01N33/68 ,  G01N33/53 ,  G01N2800/042 ,  G01N2800/32

摘要： The present invention provides a method for quantifying adiponectin including quantifying adiponectin while distinguishing between an adiponectin having physiological activity and an adiponectin having pathological activity in a quantification of adiponectin in body fluid.

公开(公告)号：US20230235478A1

公开(公告)日：2023-07-27

申请号：US18077455

申请日：2022-12-08

申请人： SHINSHU UNIVERSITY ,  Fujikoshi Machinery Corp.

发明人： Keigo HOSHIKAWA ,  Toshinori TAISHI ,  Takumi KOBAYASHI

IPC分类号： C30B11/00 ,  C30B29/16 ,  C30B35/00

CPC分类号： C30B11/002 ,  C30B29/16 ,  C30B35/002 ,  C30B11/003

摘要： A production apparatus for a metal oxide single crystal according to the present invention includes a crucible for housing a crystal raw material and a seed crystal, which has a first end and a second end, and in which the crystal raw material is disposed on a first end side, and the seed crystal is disposed on a second end side, a heater that heats the crucible, and a cooling rod, which has a third end and a fourth end, and in which the third end is provided in contact with or in proximity to the second end of the crucible so as to cool the second end by depriving the second end of heat.

公开(公告)号：US20220107370A1

公开(公告)日：2022-04-07

申请号：US17427908

申请日：2019-08-29

申请人： CITIZEN FINEDEVICE CO., LTD. ,  CITIZEN WATCH CO., LTD. ,  SHINSHU UNIVERSITY

发明人： Mitsunori MIYAMOTO ,  Toshiya KUBO ,  Toshiroh SATO ,  Yuta FUJISHIRO ,  Makoto SONEHARA

IPC分类号： G01R33/032 ,  G02F1/09

摘要： An interference type optical magnetic field sensor device 1 has a light emitter 10 emitting first linearly polarized light, a first optical element 30 emitting a first linearly polarized wave and a second linearly polarized wave orthogonal to the first linearly polarized wave with respect to incident the first linearly polarized light, and emitting a second linearly polarized light with respect to incident third linearly polarized wave and a forth linearly polarized wave orthogonal to the third linearly polarized wave, a magnetic field sensor element 50 disposed at least a portion thereof within a predetermined magnetic field an optical path unit 40 connected to the first optical element and the magnetic field sensor element, and having a first optical path propagating the first linearly polarized wave and the forth linearly polarized wave, and a second optical path propagating the second linearly polarized wave and the third linearly polarized wave, a detection signal generator 60 outputting a detection signal by separating the second linearly polarized light into an S polarization component and a P polarization component, converting the S polarization component and the P polarization component into an electric signal, and an optical branching element 20 transmitting the first linearly polarized light to the first optical element, and branching the second linearly polarized light to the detection signal generator, wherein the magnetic field sensor element emits the first linearly polarized wave and the second linearly polarized wave as incident light, and emits the third linearly polarized wave with respect to the first linearly polarized wave and the forth linearly polarized wave with respect to the second linearly polarized wave as return light.

公开(公告)号：US20220069295A1

公开(公告)日：2022-03-03

申请号：US17275022

申请日：2019-11-22

申请人： SHINSHU UNIVERSITY

发明人： Nobuyuki ZETTSU ,  Katsuya TESHIMA ,  Hyemin KIM

IPC分类号： H01M4/38 ,  H01M4/587

摘要： A negative electrode active material for a rechargeable battery of the present invention includes a silicon composite composed of a silicon compound and at least one carbon material of graphite, non-graphitizable carbon, and soft carbon, a self-assembled monolayer which covers the surface of the silicon composite and has amino groups, and a carbon compound that is bonded to the self-assembled monolayer via the amino groups and contains carbon atoms as a main component.

公开(公告)号：US20210370271A1

公开(公告)日：2021-12-02

申请号：US17304004

申请日：2021-06-11

申请人： THE PENN STATE RESEARCH FOUNDATION ,  SHINSHU UNIVERSITY

发明人： Mauricio Terrones ,  Yu Lei ,  He Liu ,  Kazunori Fujisawa ,  Ann Laura Elias Arriaga ,  Tianyi Zhang ,  Eduardo Cruz-Silva ,  Moronobu Endo ,  Xiaoxing Wang

IPC分类号： B01J21/02 ,  C01B21/064 ,  B01J23/50 ,  B01J37/00 ,  B01J23/89 ,  B01J35/10 ,  B01J35/02 ,  B01J37/04 ,  B01J37/06 ,  C25B11/097 ,  C25B1/02

摘要： A group of reductive 2D materials (R2D) with extended reactive vacancies and a method for making the R2D with extended reactive vacancies are provided, especially the example of the reductive boron nitride (RBN). To create defects such as vacancies, boron nitride (BN) powders are milled at cryogenic temperatures. Vacancies are produced by milling, and the vacancies can be used to reduce various metal nanostructures on RBN. Due to the thermal stability of the RBN and the enhanced catalytic performance of metal nanostructures, RBN-metals can be used for different catalysts, including electrochemical catalysts and high temperature catalysts.