公开(公告)号：US20110195853A1

公开(公告)日：2011-08-11

申请号：US12701712

申请日：2010-02-08

Applicant: Sam Kavusi ,  Michaela Laupheimer ,  Christoph Lang

Inventor： Sam Kavusi ,  Michaela Laupheimer ,  Christoph Lang

IPC: C40B30/04

CPC classification number: G01N33/54306 ,  G01N33/558

Abstract: A system and method of quantitating the concentration of a molecule of interest in one embodiment includes establishing a plurality of test environments at a plurality of test sites, each of the plurality of test environments associated with one of a plurality of response curves, each of the plurality of response curves different from the other of the plurality of response curves, storing a combined response curve resulting from a summation of the plurality of response curves, exposing the plurality of test sites to a sample having a concentration of a molecule of interest, obtaining a plurality of quantitation signals, each of the plurality of quantitation signals associated with one of the plurality of test sites, associating a summation of the plurality of quantitation signals with the stored combined response curve, and generating a signal related to the concentration of the molecule of interest based upon the association.

Abstract translation: 在一个实施方案中定量感兴趣的分子的浓度的系统和方法包括在多个测试位置建立多个测试环境，所述多个测试环境中的每一个与多个响应曲线之一相关联，每个测试环境 多个响应曲线不同于多个响应曲线中的另一个响应曲线，存储由多个响应曲线的总和产生的组合响应曲线，将多个测试位置暴露于具有感兴趣分子浓度的样本，获得 多个定量信号，所述多个定量信号中的每一个与所述多个测试点之一相关联，将所述多个定量信号的总和与所存储的组合响应曲线相关联，并产生与所述分子的浓度相关的信号 基于协会的兴趣。

公开(公告)号：US20110177962A1

公开(公告)日：2011-07-21

申请号：US12688193

申请日：2010-01-15

Applicant: Sam Kavusi ,  Daniel Roser ,  Christoph Lang ,  AmirAli Haj Hossein Talasaz

Inventor： Sam Kavusi ,  Daniel Roser ,  Christoph Lang ,  AmirAli Haj Hossein Talasaz

IPC: C40B30/04 ,  C40B60/12

CPC classification number: G01N33/54366 ,  B01L3/5027 ,  C12Q1/6816 ,  G01N33/54393 ,  C12Q2565/501

Abstract: A method of determining a number of a solution constituent includes introducing a first number of solution constituents to a first test location, establishing a first binding environment for the introduced first number of solution constituents, creating a first residual number of solution constituents by binding a first plurality of solution constituents, establishing a second binding environment for the first residual number of solution constituents, creating a second residual number of solution constituents by binding a second plurality of solution constituents from the first residual number of solution constituents, obtaining a first signal associated with the bound first plurality of solution constituents, obtaining a second signal associated with the bound second plurality of solution constituents, and determining a second number of a constituent of interest based upon the obtained first signal and the obtained second signal.

Abstract translation: 确定溶液成分的数量的方法包括将第一数量的溶液成分引入到第一测试位置，为所引入的第一数量的溶液成分建立第一结合环境，通过将第一数量的溶液成分结合到第一残留数量的溶液成分 多个溶液成分，为第一剩余数量的溶液组分建立第二结合环境，通过将第二多个溶液组分与第一剩余数量的溶液组分结合而产生第二剩余数量的溶液组分，获得与 绑定的第一多个解决方案组成部分，获得与绑定的第二多个解决方案组成部分相关联的第二信号，以及基于获得的第一信号和获得的第二信号来确定感兴趣的组成部分的第二数量。

公开(公告)号：US07936291B2

公开(公告)日：2011-05-03

申请号：US12249746

申请日：2008-10-10

Applicant: Robert Wolf ,  Christoph Lang ,  Xinyu Xing ,  Sam Kavusi ,  Chinwuba Ezekwe

Inventor： Robert Wolf ,  Christoph Lang ,  Xinyu Xing ,  Sam Kavusi ,  Chinwuba Ezekwe

IPC: H03M1/06

CPC classification number: H03F3/005

Abstract: A method compensates for errors in an output signal of a comparator based/zero crossing based circuit. The method includes generating with a comparator based/zero crossing based switched capacitor circuit a first output signal with an input signal, generating with the comparator based/zero crossing based switched capacitor circuit a second output signal with the input signal of an opposite polarity, and subtracting the second output signal from the first output signal to generate a final output signal for the comparator based/zero crossing based switched capacitor circuit.

Abstract translation: 一种补偿基于比较器/基于零交叉的电路的输出信号中的误差的方法。 该方法包括利用基于比较器的/基于零交叉的开关电容器电路产生具有输入信号的第一输出信号，利用基于比较器的/基于零交叉的开关电容器电路产生具有相反极性的输入信号的第二输出信号，以及 从第一输出信号减去第二输出信号以产生用于基于比较器/基于零交叉的开关电容器电路的最终输出信号。

公开(公告)号：US20110001515A1

公开(公告)日：2011-01-06

申请号：US12497216

申请日：2009-07-02

Applicant: Robert Wolf ,  Christoph Lang ,  Xinyu Xing ,  Sam Kavusi

Inventor： Robert Wolf ,  Christoph Lang ,  Xinyu Xing ,  Sam Kavusi

IPC: G01R19/00

CPC classification number: H03F1/38 ,  H03K5/08 ,  H03K5/2481

Abstract: A method and circuit for attenuating positive feedback in a comparator in one embodiment includes an amplifier configured to compare a first input signal with a second input signal and to provide an output based upon the comparison, a non-linear function with a first input operably connected to an output of the amplifier, and a feedback loop operably connected to the output of the non-linear function and to a second input of the non-linear function, the feedback loop including a feedback limiting circuit configured to attenuate a feedback signal to the second input of the non-linear function.

Abstract translation: 在一个实施例中用于衰减比较器中的正反馈的方法和电路包括：放大器，被配置为将第一输入信号与第二输入信号进行比较，并且基于比较提供输出，非线性函数与第一输入可操作地连接 耦合到放大器的输出端，以及可操作地连接到非线性功能的输出端和非线性功能的第二输入端的反馈回路，反馈回路包括反馈限制电路，该反馈限制电路被配置为将反馈信号衰减到 第二输入的非线性函数。

公开(公告)号：US20100090724A1

公开(公告)日：2010-04-15

申请号：US12249746

申请日：2008-10-10

Applicant: Robert Wolf ,  Christoph Lang ,  Xinyu Xing ,  Sam Kavusi ,  Chinwuba Ezekwe

Inventor： Robert Wolf ,  Christoph Lang ,  Xinyu Xing ,  Sam Kavusi ,  Chinwuba Ezekwe

IPC: H03K5/00

CPC classification number: H03F3/005

Abstract: A method compensates for errors in an output signal of a comparator based/zero crossing based circuit. The method includes generating with a comparator based/zero crossing based switched capacitor circuit a first output signal with an input signal, generating with the comparator based/zero crossing based switched capacitor circuit a second output signal with the input signal of an opposite polarity, and subtracting the second output signal from the first output signal to generate a final output signal for the comparator based/zero crossing based switched capacitor circuit.

Abstract translation: 一种补偿基于比较器/基于零交叉的电路的输出信号中的误差的方法。 该方法包括利用基于比较器的/基于零交叉的开关电容器电路产生具有输入信号的第一输出信号，利用基于比较器的/基于零交叉的开关电容器电路产生具有相反极性的输入信号的第二输出信号，以及 从第一输出信号减去第二输出信号以产生用于基于比较器/基于零交叉的开关电容器电路的最终输出信号。

公开(公告)号：US09946836B2

公开(公告)日：2018-04-17

申请号：US13017391

申请日：2011-01-31

Applicant: Sam Kavusi ,  Christoph Lang

Inventor： Sam Kavusi ,  Christoph Lang

IPC: G01N33/48 ,  G06F19/28 ,  G06F19/00

CPC classification number: G06F19/28 ,  G16H10/40 ,  G16H15/00 ,  G16H50/30

Abstract: A biomarker monitoring method and system in one embodiment includes a communications network, a portable wellness device configured to form a communication link with the communications network, the portable wellness device including a detector configured to detect at least one biomarker in a biologic sample, a first memory, a plurality of program instructions stored in the first memory, and a processing circuit operably connected to the first memory and configured to execute the program instructions to generate wellness data based upon detection of the at least one biomarker in the biologic sample, and a remote user interface operably connected to the communications network and configured to render the wellness data.

公开(公告)号：US09927435B2

公开(公告)日：2018-03-27

申请号：US12580113

申请日：2009-10-15

Applicant: Sam Kavusi ,  Daniel Roser ,  Christoph Lang ,  AmirAli Haj Hossein Talasaz

Inventor： Sam Kavusi ,  Daniel Roser ,  Christoph Lang ,  AmirAli Haj Hossein Talasaz

IPC: G01N33/00 ,  G01N33/543 ,  G01N29/32 ,  G01N33/53

CPC classification number: G01N33/54393 ,  G01N29/32 ,  G01N33/53 ,  G01N33/543 ,  G01N33/54366

Abstract: A method of detecting a biomarker in one embodiment includes identifying a quantity of biomolecule types in a sample, exposing the sample to a plurality of test sites, wherein the number of test sites in the plurality of test sites is equal to or greater than the identified quantity of biomolecule types, establishing, for each of the plurality of test sites, a respective test environment, wherein the test environment for each of the plurality of test sites is different from the test environment for each of the other of the plurality of test sites, obtaining a detection signal associated with each of the plurality of test sites, and determining the concentration of one of the biomolecule types based upon the obtained detection signals.

公开(公告)号：US09274179B2

公开(公告)日：2016-03-01

申请号：US12329961

申请日：2008-12-08

Applicant: Sam Kavusi ,  Christoph Lang ,  Thomas Rocznik ,  Chinwuba Ezekwe

Inventor： Sam Kavusi ,  Christoph Lang ,  Thomas Rocznik ,  Chinwuba Ezekwe

IPC: G01D18/00 ,  G01R33/00 ,  G01R33/07

CPC classification number: G01R33/0029 ,  G01D18/008 ,  G01R33/072 ,  G01R33/075

Abstract: A method and system for providing increased accuracy in a CMOS sensor system in one embodiment includes a plurality of sensor elements having a first terminal and a second terminal on a complementary metal oxide semiconductor substrate, a first plurality of switches configured to selectively connect the first terminal to a power source and to selectively connect the first terminal to a readout circuit, and a second plurality of switches configured to selectively connect the second terminal to the power source and to selectively connect the second terminal to the readout circuit.

Abstract translation: 在一个实施例中，在CMOS传感器系统中提供更高精度的方法和系统包括多个传感器元件，其具有在互补金属氧化物半导体衬底上的第一端子和第二端子，第一多个开关被配置为选择性地将第一端子 并且将第一端子选择性地连接到读出电路，以及第二多个开关，其被配置为选择性地将第二端子连接到电源并且将第二端子选择性地连接到读出电路。

公开(公告)号：US09063138B2

公开(公告)日：2015-06-23

申请号：US13348727

申请日：2012-01-12

Applicant: Michael Chen ,  Vincent Chen ,  Sam Kavusi ,  Christoph Lang

Inventor： Michael Chen ,  Vincent Chen ,  Sam Kavusi ,  Christoph Lang

IPC: G01N33/53 ,  G01N33/543 ,  C08F20/56

CPC classification number: G01N33/54393 ,  C08F20/56 ,  G01N33/5306 ,  Y10T436/11 ,  Y10T436/115831

Abstract: A system and method of indirectly modifying an environmental condition at a test site in one embodiment includes providing a test site on a substrate, providing a hydrogel composition loaded with a chemical factor at the test site, providing an actuator configured to activate the hydrogel composition to release a chemical factor at the test site, controlling the actuator to activate the hydrogel composition to release a chemical factor at the test site, and modifying the local chemical environment at the test site with the chemical factor.

Abstract translation: 在一个实施方案中间接改变测试部位的环境条件的系统和方法包括在基底上提供测试部位，在测试部位提供装载有化学因子的水凝胶组合物，提供构造成将水凝胶组合物活化的致动器 在试验现场释放化学因子，控制致动器激活水凝胶组合物以释放在试验部位的化学因子，并用化学因子改变试验部位的局部化学环境。

公开(公告)号：US08648016B2

公开(公告)日：2014-02-11

申请号：US12701712

申请日：2010-02-08

Applicant: Sam Kavusi ,  Michaela Laupheimer ,  Christoph Lang

Inventor： Sam Kavusi ,  Michaela Laupheimer ,  Christoph Lang

IPC: C40B30/04

CPC classification number: G01N33/54306 ,  G01N33/558

Abstract: A system and method of quantitating the concentration of a molecule of interest in one embodiment includes establishing a plurality of test environments at a plurality of test sites, each of the plurality of test environments associated with one of a plurality of response curves, each of the plurality of response curves different from the other of the plurality of response curves, storing a combined response curve resulting from a summation of the plurality of response curves, exposing the plurality of test sites to a sample having a concentration of a molecule of interest, obtaining a plurality of quantitation signals, each of the plurality of quantitation signals associated with one of the plurality of test sites, associating a summation of the plurality of quantitation signals with the stored combined response curve, and generating a signal related to the concentration of the molecule of interest based upon the association.

Abstract translation: 在一个实施方案中定量感兴趣的分子的浓度的系统和方法包括在多个测试位置建立多个测试环境，所述多个测试环境中的每一个与多个响应曲线之一相关联，每个测试环境 多个响应曲线不同于多个响应曲线中的另一个响应曲线，存储由多个响应曲线的总和产生的组合响应曲线，将多个测试位置暴露于具有感兴趣分子浓度的样本，获得 多个定量信号，所述多个定量信号中的每一个与所述多个测试点之一相关联，将所述多个定量信号的总和与所存储的组合响应曲线相关联，并产生与所述分子的浓度相关的信号 基于协会的兴趣。