公开(公告)号：US20230138393A1

公开(公告)日：2023-05-04

申请号：US17904229

申请日：2021-02-12

Applicant: Temple University-Of The Commonwealth System of Higher Education

Inventor： Rongsheng E. Wang ,  Md Shafiqul Islam ,  Zhigang Lyu ,  Yue Zhao ,  Zakey Yusuf Buuh

IPC: C07K1/107 ,  A61K47/54

Abstract: This invention provides compositions comprising linked amino acid sequences, pharmaceutical compositions comprising linked amino acid sequences, and methods of making thereof. This invention also provides methods of delivering said compositions to subjects and methods of treating various disorders and diseases using the said compositions.

公开(公告)号：US20230073246A1

公开(公告)日：2023-03-09

申请号：US17938209

申请日：2022-10-05

Applicant: TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： Arthur M. Feldman ,  Douglas G. Tilley ,  Weizhong Zhu ,  Kamel Khalili ,  Walter J. Koch

IPC: C12Q1/6883 ,  G01N33/68

Abstract: Compositions are directed to BCL2-associated athanogene 3 (BAG3) molecules and agents which modulate expression of BAG3 molecules. Pharmaceutical composition for administration to patients, for example, patients with heart failure, comprise one or more BAG3 molecules or agents which modulate expression of BAG3. Methods of treatment and identifying candidate therapeutic agents are also provided.

公开(公告)号：US11598841B1

公开(公告)日：2023-03-07

申请号：US16854251

申请日：2020-04-21

Applicant: Temple University-Of The Commonwealth System of Higher Education ,  Government of the United States, as represented by the Secretary of the Air Force

Inventor： Ammar Ahmed ,  Yimin Daniel Zhang ,  Braham Himed

IPC: G01S7/00 ,  G01S13/00

Abstract: A system for distributed dual-function radar-communication comprises a plurality of dual-function radar transmitters positioned within a region of interest, each configured to transmit at least one radar waveform, with each transmitter for having a minimum transmit power, a maximum transmit power, and a working transmit power, a plurality of radar receivers positioned within the region of interest, each configured to receive the radar waveforms, at least one controller communicatively connected to at least one connected transmitter of the plurality of dual-function radar transmitters, configured to calculate a vector of transmit power values for the plurality of dual-function radar transmitters. A method of transmitting a radar waveform is also disclosed.

公开(公告)号：US20230019261A1

公开(公告)日：2023-01-19

申请号：US17781886

申请日：2020-12-01

Applicant: Temple University-Of The Commonwealth System of Higher Education

Inventor： John Todd Kuenstner ,  Raghava Potula

IPC: G01N33/564

Abstract: The present invention generally relates to kits for detecting Mycobacterium avium subspecies paratuberculosis (MAP) infection and biomarkers correlated with MAP-associated diseases or disorders. The present method also relates to methods of diagnosing a subject with a MAP-associated autoimmune disease or disorder and/or determining the treatment course of a subject diagnosed with a MAP-associated autoimmune disease or disorder.

公开(公告)号：US20220251552A1

公开(公告)日：2022-08-11

申请号：US17441596

申请日：2020-03-23

Applicant: The Trustees of the University of Pennsylvania ,  Temple University - Of The Commonwealth System Of Higher Education

Inventor： Hao SHEN ,  Yan WANG ,  Ying TIAN

IPC: C12N15/113 ,  A61P11/00 ,  A61P31/04

Abstract: The present invention relates to methods and compositions comprising a miR-302 mimic/s for treatment of lung injury. The miRNA-302 mimic/s facilitate host recovery from lung injury caused due to, for example, bacterial pneumonia

公开(公告)号：US20220240837A1

公开(公告)日：2022-08-04

申请号：US17727599

申请日：2022-04-22

Applicant: Monell Chemical Senses Center ,  Temple University-of The Commonwealth System of Higher Education

Inventor： Pamela H. DALTON ,  Danielle REED ,  Valentina PARMA ,  Maureen O'LEARY ,  Mackenzie HANNUM

IPC: A61B5/00 ,  G16H10/40 ,  G16H10/20

Abstract: Provided are systems, methods, and kits for multifunctional smell assessment. The kits may comprise a first surface adhered by a first releasable adhesive comprising an odorous volatile compound; and the system for registering if the odorous volatile compound is detected by a user. The system or method may comprise queries for obtaining a first input on whether the user detects and identifies the odorous volatile compound, and an intensity by which the odor is perceived.

公开(公告)号：US11337640B2

公开(公告)日：2022-05-24

申请号：US17111114

申请日：2020-12-03

Applicant: Monell Chemical Senses Center ,  Temple University—of The Commonwealth System of Higher Education

Inventor： Pamela H. Dalton ,  Danielle Reed ,  Valentina Parma ,  Maureen O'Leary ,  Mackenzie Hannum

IPC: A61B5/00 ,  G16H10/40 ,  G16H10/20

Abstract: Provided are systems, methods, and kits for multifunctional smell assessment. The kits may comprise a first surface adhered by a first releasable adhesive comprising an odorous volatile compound; and the system for registering if the odorous volatile compound is detected by a user. The system or method may comprise queries for obtaining a first input on whether the user detects and identifies the odorous volatile compound, and an intensity by which the odor is perceived.

公开(公告)号：US11319327B2

公开(公告)日：2022-05-03

申请号：US17015696

申请日：2020-09-09

Applicant: Temple University—Of The Commonwealth System of Higher Education ,  Praeventix, LLC

Inventor： Daniel J. Canney ,  Benjamin E. Blass ,  Kevin M. Blattner ,  Douglas A. Pippin

IPC: C07D491/107 ,  C07D221/00 ,  C07D295/073 ,  C07D309/08 ,  C07D493/10 ,  C07D513/04 ,  C07F7/10 ,  C07D413/10

Abstract: Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity.

公开(公告)号：US11298411B2

公开(公告)日：2022-04-12

申请号：US15884427

申请日：2018-01-31

Applicant: Temple University of the Commonwealth System of Higher Education

Inventor： Kamel Khalili ,  Wenhui Hu

IPC: A61K38/46 ,  C12N15/11 ,  A61K48/00 ,  A61K9/00 ,  A61K35/12 ,  A61K45/06 ,  C12N7/00 ,  C12N9/22

Abstract: A method of treating a subject having a retroviral infection, by administering to the subject a therapeutically effective amount of a composition comprising a vector encoding a CRISPR-associated endonuclease and at least two guide RNAs, wherein the guide RNAs are complementary to two target sequences spanning from the 5′- to 3′-LTRs of the sequence in the retrovirus, and eradicating the retroviral infection. A method of immunizing a subject at risk of retroviral infection, by administering a prophylactically effective amount of a composition comprising a Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated endonuclease, and two or more different guide RNAs (gRNAs), wherein each of the at least two gRNAs is complementary to a different target nucleic acid sequence in a long terminal repeat (LTR) of proviral DNA of a retrovirus to the subject, and preventing retroviral infection in the subject.

公开(公告)号：US20210322321A1

公开(公告)日：2021-10-21

申请号：US17284746

申请日：2019-10-17

Applicant: Temple University-Of The Commonwealth System of Higher Education

Inventor： Reza A. Fassihi

IPC: A61K9/20 ,  A61K45/06 ,  A61K9/28

Abstract: A tamper resistant drug dosage is described. The drug dosage form includes a matrix polymer, a scaffold polymer, and a therapeutic agent, and the porosity of the drug dosage form is less than 10%. Methods for making and using the tamper resistant drug dosage forms are described.