公开(公告)号：US10125373B2

公开(公告)日：2018-11-13

申请号：US14762128

申请日：2014-01-22

Applicant: THE ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY ,  Hugh Mason ,  Charles Arntzen ,  Sun Hee Rosenthal ,  Sean Winkle ,  Andrew Diamos

Inventor： Hugh Mason ,  Charles Arntzen ,  Sun Hee Rosenthal ,  Sean Winkle ,  Andrew Diamos

IPC: C12N15/82 ,  C07K16/28 ,  C12N7/00

Abstract: A single vector or multiple separate vectors that contain two or more non-competing replicons for transient expression of the heavy and light chains of Rituximab in Nicotiana benthamiana leaves is described. The correct assembly of these subunit proteins into functional oligomeric structures to optimize the expression is also described. This system advances plant transient expression technology by eliminating the need for non-competing viruses, and thus, enhances the realistic commercial application of the multi-replicon single vector system for producing Rituximab in plant cells.

公开(公告)号：US20180320189A1

公开(公告)日：2018-11-08

申请号：US15850957

申请日：2017-12-21

Applicant: The Arizona Board of Regents for and on Behalf of Arizona State University ,  The Washington University

Inventor： Roy Curtiss, III ,  Shifeng Wang ,  Soo-young Wanda ,  Wei Kong

IPC: C12N15/74 ,  A61K39/00 ,  C12N1/36

CPC classification number: C12N15/74 ,  A61K35/74 ,  A61K39/00 ,  A61K2035/11 ,  A61K2039/522 ,  A61K2039/523 ,  C12N1/36

Abstract: The invention relates to compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens of interest.

公开(公告)号：US20170306338A1

公开(公告)日：2017-10-26

申请号：US15423675

申请日：2017-02-03

Applicant: The Arizona Board of Regents for and on Behalf of Arizona State University

Inventor： Roy Curtiss, III ,  Wei Kong

IPC: C12N15/74 ,  A61K35/74 ,  C12N1/36 ,  C12R1/42

CPC classification number: C12N15/74 ,  A61K35/74 ,  C12N1/36 ,  C12R1/42

Abstract: The present invention encompasses a recombinant bacterium capable of reducing tumor growth.

公开(公告)号：US20170048298A9

公开(公告)日：2017-02-16

申请号：US14563712

申请日：2014-12-08

Applicant: The Arizona Board of Regents for and on Behalf of Arizona State University

Inventor： RIDA A. BAZZI ,  MOHSEN ZOHREVANDI

IPC: H04L29/08 ,  G06F21/52 ,  G06F21/62

Abstract: A system and method for securing access to sensitive content on the web is disclosed. The approach automates compartmentalization practices for accessing different kinds of content with different browser instances. The automation is transparent to the user and does not require any modification of how non-sensitive content is accessed. For sensitive content, a Fresh Browser Instance (FBI) is automatically created to access the content. In addition, the automatic FBI system may provide support for novice users with predefined sensitive content sites as well as for more experienced users who can define conflict of interest (COI) classes which allows content from sites in the same user-defined class to coexist in a browser instance.

Abstract translation: 公开了一种用于确保对网络上敏感内容的访问的系统和方法。 该方法可以自动执行不同浏览器实例访问不同种类的内容的区域化实践。 自动化对用户是透明的，不需要修改非敏感内容的访问方式。 对于敏感内容，会自动创建新鲜浏览器实例（FBI）来访问内容。 此外，自动FBI系统可以为具有预定义敏感内容站点的新手用户以及可以定义利益冲突（COI）类的更多有经验的用户提供支持，这些用户允许来自同一用户定义类中的站点的内容共存 浏览器实例。

公开(公告)号：US20160164946A1

公开(公告)日：2016-06-09

申请号：US14563712

申请日：2014-12-08

Applicant: The Arizona Board of Regents for and on Behalf of Arizona State University

Inventor： RIDA A. BAZZI ,  MOHSEN ZOHREVANDI

IPC: H04L29/08 ,  G06F21/52 ,  G06F21/62

Abstract: A system and method for securing access to sensitive content on the web is disclosed. The approach automates compartmentalization practices for accessing different kinds of content with different browser instances. The automation is transparent to the user and does not require any modification of how non-sensitive content is accessed. For sensitive content, a Fresh Browser Instance (FBI) is automatically created to access the content. In addition, the automatic FBI system may provide support for novice users with predefined sensitive content sites as well as for more experienced users who can define conflict of interest (COI) classes which allows content from sites in the same user-defined class to coexist in a browser instance.

Abstract translation: 公开了一种用于确保对网络上敏感内容的访问的系统和方法。 该方法可以自动执行不同浏览器实例访问不同种类的内容的区域化实践。 自动化对用户是透明的，不需要修改非敏感内容的访问方式。 对于敏感内容，会自动创建新鲜浏览器实例（FBI）来访问内容。 此外，自动FBI系统可以为具有预定义敏感内容站点的新手用户以及可以定义利益冲突（COI）类的更多有经验的用户提供支持，这些用户允许来自同一用户定义类中的站点的内容共存 浏览器实例。

公开(公告)号：US20150140666A1

公开(公告)日：2015-05-21

申请号：US14406461

申请日：2013-06-10

Applicant: THE ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Michael L. Fisher ,  Roy Curtiss III ,  Rebecca Custer Allen

IPC: C12N15/82 ,  C07K14/405 ,  C07K14/24 ,  C07K14/245

CPC classification number: C12N1/20 ,  C07K14/195 ,  C07K14/24 ,  C07K14/245 ,  C07K14/405 ,  C12N15/74 ,  C12N15/82 ,  C12N15/8238

Abstract: The present invention encompasses a phototrophic microorganism with altered and controlled adhesive properties. One aspect of the present invention encompasses a genetically modified phototrophic microorganism capable of controlled adhesion. The microorganism comprises a recombinant nucleic acid construct, wherein the nucleic acid construct comprises an inducible promoter operably-linked to a nucleic acid encoding an adhesion protein.

Abstract translation: 本发明包括具有改变和控制的粘合性质的光养微生物。 本发明的一个方面包括能够控制粘附的遗传修饰的光营养微生物。 微生物包含重组核酸构建体，其中所述核酸构建体包含与编码粘附蛋白的核酸可操作地连接的诱导型启动子。