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公开(公告)号：US12275786B2
公开(公告)日：2025-04-15
申请号：US17817599
申请日：2022-08-04
Inventor： Kenichi Hanada , Qiong J. Wang , James C. Yang , Zhiya Yu
Abstract: Disclosed is a synthetic T cell receptor (TCR) having antigenic specificity for an HLA-A2-restricted epitope of thyroglobulin (TG), TG470-478. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells are also provided. Antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.
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公开(公告)号：US12274741B2
公开(公告)日：2025-04-15
申请号：US18442506
申请日：2024-02-15
Inventor： Felicito Guerrero , Kylie G Bendele , Luisa N Domingues
Abstract: The invention relates to antigenic polypeptides derived from a naturally occurring R. microplus protein, and nucleic acids encoding such polypeptides. The polypeptides elicit an immune response which, in turn, produces detrimental effects in R. microplus feeding on vaccinated cattle. Thus, the present disclosure provides novel vaccines to protect cattle from R. microplus infestation.
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公开(公告)号：US12274100B1
公开(公告)日：2025-04-08
申请号：US18433366
申请日：2024-02-05
Applicant: Government of the United States of America as represented by the Secretary of the Air Force
Inventor： Geoffrey Keith Bradshaw
IPC: H10F77/14 , H10F19/90 , H10F77/124
Abstract: Systems, methods and apparatus related to a multijunction solar cell. The apparatus comprises a first sub-solar cell, a second sub-solar cell in series with the first sub-solar cell and one or more quantum wells. At least some of the quantum wells are disposed in a region of the first sub-solar cell, and have a thickness and a bandgap sized such that a bandgap in selected quantum wells are less than a bandgap of a material of the first sub-solar cell and greater than a bandgap of a material of the second sub-solar cell resulting in radiative coupling between the first sub-solar cell and the second sub-solar cell.
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公开(公告)号：US12270814B2
公开(公告)日：2025-04-08
申请号：US18482286
申请日：2023-10-06
Applicant: Wayne State University , The United States of America, as Represented by the Secretary, Department of Health & Human Services
Inventor： Adi L. Tarca , Piya Chaemsaithong , Tinnakorn Chaiworapongsa , Sonia S. Hassan , Roberto Romero
IPC: G01N33/53 , A61K35/16 , C12Q1/6883 , G01N33/68
Abstract: Biomarkers tests which can be used to predict a positive or negative risk of preeclampsia are described. More specifically, a panel of biomarkers including MMP-7 and gpIIbIIIa, described. The test is useful to predict preeclampsia when a biological sample is obtained between the 16th and 22nd week of pregnancy. Prediction later in pregnancy can be achieved by a combination of Siglec-6, Activin A, ALCAM, and/or FCN2.
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公开(公告)号：US12270738B2
公开(公告)日：2025-04-08
申请号：US17716606
申请日：2022-04-08
Applicant: The United States of America, as represented by the Secretary, Dept. of Health and Human Services
Inventor： Stephen M. Hewitt , Joon-Yong Chung , Candice D. Perry , Robert A. Star
IPC: G01N1/30
Abstract: Disclosed herein are compositions for fixing tissue for cytologic, histomorphologic, and/or molecular analysis (e.g., DNA, RNA, and/or protein analysis). In some embodiments, the fixatives are aldehyde-free fixatives, for example, formaldehyde- or formalin-free fixatives. Particular disclosed compositions include buffered ethanol. The buffer is a phosphate buffer or phosphate buffered saline (PBS) in some examples. In further embodiments, the fixative includes additional components, such as glycerol and/or acetic acid.
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Patent Agency Ranking
公开(公告)号：US12270334B2
公开(公告)日：2025-04-08
申请号：US15869932
申请日：2018-01-12
Applicant: The Government of the United States of America, as represented by the Secretary of the Navy
Inventor： Jesse R Maxwell , Gabriel B Goodwin
Abstract: A shapeable inlet manifold for a hypersonic scramjet includes an inlet lower cowling; a mount surface; and an inlet stream surface movably coupled to the mount surface, wherein the inlet lower cowling and the inlet stream surface define an opening of the shapeable inlet manifold allowing fluid flow therethrough. The inlet stream surface has first and second dispositions relative to the lower cowling defining first and second shapes of the opening, thereby providing respective first and second flow characteristics through the inlet manifold during flight.
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公开(公告)号：US12268737B2
公开(公告)日：2025-04-08
申请号：US18648190
申请日：2024-04-26
Inventor： John R. Mascola , Jeffrey C. Boyington , Hadi M. Yassine , Peter D. Kwong , Barney S. Graham , Masaru Kanekiyo
IPC: A61K39/145 , A61K39/12 , C07K14/005 , C07K14/47 , C12N7/00 , A61K39/00
Abstract: Vaccines that elicit broadly protective anti-influenza antibodies. Some vaccines comprise nanoparticles that display HA trimers from influenza virus on their surface. The nanoparticles are fusion proteins comprising a monomeric subunit (e.g., ferritin) joined to the stem region of an influenza HA protein. The fusion proteins self-assemble to form the HA-displaying nanoparticles. The vaccines comprise only the stem region of an influenza HA protein joined to a trimerization domain. Also provided are fusion proteins, and nucleic acid molecules encoding such proteins, and assays using nanoparticles of the invention to detect anti-influenza antibodies.
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公开(公告)号：US12268551B2
公开(公告)日：2025-04-08
申请号：US17526798
申请日：2021-11-15
Applicant: Wayne State University , The United States of America, as represented by the Secretary, Department of Health and Human Services , Gustavo Eduardo Abella , Ricardo Enrique Gayoso
Inventor： Lami Yeo , Roberto Romero , Gustavo Eduardo Abella , Ricardo Enrique Gayoso
Abstract: A method and apparatus of examining fetal hearts includes obtaining ultrasound data of a fetal heart to generate fetal heart images, displaying different marked sample images of a fetal heart and at respective cardiac phases, each marking a different feature of a fetal heart at a respective marked location, and sequentially presenting one of the different marked sample images to a user along with one of the fetal heart images that is a similar view. As each of the different marked sample images is sequentially presented, a user is prompted to mark the different feature in a respective fetal heart image based on its marked location to create a plurality of marked fetal heart images, and a geometric model of the heart is generated based on the marked fetal heart images, from which fetal echocardiography views can be extracted. The fetal echocardiography views of the fetal heart are displayed.
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29.发明申请公开(公告)号：US20250111676A1
公开(公告)日：2025-04-03
申请号：US18979033
申请日：2024-12-12
Applicant: The Government of the United States of America, as represented by the Secretary of Homeland Security
Inventor： John Fortune , Brian Lewis , Michelle Weinberger
Abstract: An example method to characterize an anomaly includes obtaining information about an item using a first mode scan and detecting whether the item contains an anomaly based on the information. The method further includes determining, responsive to detecting the anomaly, an area of interest of the item corresponding to a location of the anomaly, and determining a strategy including a procedure to obtain other information of the area of interest. The method refines a characterization of the anomaly based on the other information, and compares the characterization of the anomaly to a predetermined criterion. The method iteratively revises the strategy to perform additional available procedures, to further refine the characterization of the anomaly. When the characterization of the anomaly meets the predetermined criterion corresponding to a prohibited item, the method identifies the anomaly as prohibited.
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公开(公告)号：US20250110362A1
公开(公告)日：2025-04-03
申请号：US18902229
申请日：2024-09-30
Abstract: Exemplary embodiments include buried electrodes that allow for bottom electrode integration with photonic devices, while retaining the ability to perform the high-temperature processing steps used in low-loss photonic elements. In addition to functionality in the case of buried heaters for thermal tuning of devices, the same or similar techniques can be applied to other tuning mechanisms, based on the electro-optical effect and (piezoelectrically-mediated) stress-optical effect.
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