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公开(公告)号：US11130785B2
公开(公告)日：2021-09-28
申请号：US16025858
申请日：2018-07-02
发明人： Peter D. Kwong , Barney S. Graham , Jason S. McLellan , Jeffrey Boyington , Lei Chen , Man Chen , Gwo-Yu Chuang , Ivelin Stefanov Georgiev , Jason Gorman , Michael Gordon Joyce , Masaru Kanekiyo , Gilad Ofek , Marie Pancera , Mallika Sastry , Cinque Soto , Sanjay Srivatsan , Guillaume Stewart-Jones , Yongping Yang , Baoshan Zhang , Tongqing Zhou
IPC分类号： A61K39/155 , C07K14/005 , A61K39/12 , C12N7/00 , G01N33/564 , A61K39/00
摘要： Disclosed are Respiratory Syncytial Virus (RSV) antigens including a recombinant RSV F protein stabilized in a prefusion conformation. Also disclosed are nucleic acids encoding the antigens and methods of producing the antigens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the antigen to the subject.
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2.发明授权公开(公告)号：US10815295B2
公开(公告)日：2020-10-27
申请号：US16044083
申请日：2018-07-24
发明人： Peter D. Kwong , Gary J. Nabel , Rebecca S. Rudicell , John Mascola , Mark Connors , Ivelin Georgiev , Jiang Zhu , Young Do Kwon , Tongqing Zhou , Yongping Yang , Baoshan Zhang , Gwo-Yu Chuang , Xueling Wu , Zhi-yong Yang , Wei Shi
IPC分类号： C07K16/10 , G01N33/569 , A61K39/42 , A61K45/06 , A61K39/00
摘要： Monoclonal neutralizing antibodies that specifically bind to HIV-1 gp120 and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV infection is disclosed.
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公开(公告)号：US10137107B2
公开(公告)日：2018-11-27
申请号：US15512493
申请日：2015-09-18
申请人： New York Blood Center, Inc. , The United States of America, as Represented by the Secretary, Department of Health and Human Services
IPC分类号： C07D403/12 , A61K31/40 , C07D405/14 , C07D417/12 , C07D417/14 , C07D207/34 , C07C25/00 , C07C233/01 , C07D207/30 , C07D277/20 , A61P31/18
摘要： Substituted phenylpyrrolecarboxamide compounds such as those represented by Formula A can be used in the treatment of HIV infection and related conditions.
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公开(公告)号：US11969466B2
公开(公告)日：2024-04-30
申请号：US18314052
申请日：2023-05-08
发明人： John R. Mascola , Jeffrey C. Boyington , Hadi M. Yassine , Peter D. Kwong , Barney S. Graham , Masaru Kanekiyo
IPC分类号： A61K39/145 , A61K39/12 , C07K14/005 , C07K14/47 , C12N7/00 , A61K39/00
CPC分类号： A61K39/145 , A61K39/12 , C07K14/005 , C07K14/47 , C12N7/00 , A61K2039/55555 , A61K2039/55566 , A61K2039/6031 , C07K2319/00 , C12N2760/16122 , C12N2760/16134
摘要： Vaccines that elicit broadly protective anti-influenza antibodies. Some vaccines comprise nanoparticles that display HA trimers from influenza virus on their surface. The nanoparticles are fusion proteins comprising a monomeric subunit (e.g., ferritin) joined to the stem region of an influenza HA protein. The fusion proteins self-assemble to form the HA-displaying nanoparticles. The vaccines comprise only the stem region of an influenza HA protein joined to a trimerization domain. Also provided are fusion proteins, and nucleic acid molecules encoding such proteins, and assays using nanoparticles of the invention to detect anti-influenza antibodies.
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公开(公告)号：US11084850B2
公开(公告)日：2021-08-10
申请号：US16468174
申请日：2017-12-15
申请人： INSTITUTE FOR RESEARCH IN BIOMEDICINE , THE PIRBRIGHT INSTITUTE , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人： Lei Chen , Baoshan Zhang , Peter D. Kwong , Davide Corti , Antonio Lanzavecchia , Geraldine Taylor
IPC分类号： C07K14/135 , A61K39/12 , A61K39/155 , C07K14/005 , A61P31/14 , A61K39/39 , A61K45/06 , C07K16/10 , G01N33/536 , G01N33/569 , A61K39/00
摘要： The present invention provides immunogens comprising a recombinant Respiratory Syncytial Virus (RSV) F protein stabilized in a prefusion conformation and nucleic acids encoding such immunogens. In particular the present invention provides polypeptides, polynucleotides, compositions, and uses thereof for eliciting an immune response to bovine respiratory syncytial virus (bRSV). Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the antigen to the subject.
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公开(公告)号：US10363301B2
公开(公告)日：2019-07-30
申请号：US15313265
申请日：2015-05-27
发明人： John R. Mascola , Jeffrey C. Boyington , Hadi M. Yassine , Peter D. Kwong , Barney S. Graham , Masaru Kanekiyo
IPC分类号： A61K39/145 , C12N7/00 , A61K39/12 , C07K14/005 , C07K14/47 , A61K39/00
摘要： Vaccines that elicit broadly protective anti-influenza antibodies. Some vaccines comprise nanoparticles that display HA trimers from influenza virus on their surface. The nanoparticles are fusion proteins comprising a monomeric subunit (e.g., ferritin) joined to the stem region of an influenza HA protein. The fusion proteins self-assemble to form the HA-displaying nanoparticles. The vaccines comprise only the stem region of an influenza HA protein joined to a trimerization domain. Also provided are fusion proteins, and nucleic acid molecules encoding such proteins, and assays using nanoparticles of the invention to detect anti-influenza antibodies.
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公开(公告)号：US20180319846A1
公开(公告)日：2018-11-08
申请号：US16025858
申请日：2018-07-02
申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services
发明人： Peter D. Kwong , Barney S. Graham , Jason S. McLellan , Jeffrey Boyington , Lei Chen , Man Chen , Gwo-Yu Chuang , Ivelin Stefanov Georgiev , Jason Gorman , Michael Gordon Joyce , Masaru Kanekiyo , Gilad Ofek , Marie Pancera , Mallika Sastry , Cinque Soto , Sanjay Srivatsan , Guillaume Stewart-Jones , Yongping Yang , Baoshan Zhang , Tongqing Zhou
IPC分类号： C07K14/005 , A61K39/155 , C12N7/00 , A61K39/12 , G01N33/564 , A61K39/00
CPC分类号： C07K14/005 , A61K39/12 , A61K39/155 , A61K2039/5252 , A61K2039/5254 , A61K2039/53 , A61K2039/543 , A61K2039/55505 , A61K2039/55561 , A61K2039/55566 , C07K2319/21 , C07K2319/22 , C07K2319/50 , C07K2319/70 , C07K2319/735 , C12N7/00 , C12N2710/10343 , C12N2760/18522 , C12N2760/18534 , G01N33/564
摘要： Disclosed are Respiratory Syncytial Virus (RSV) antigens including a recombinant RSV F protein stabilized in a prefusion conformation. Also disclosed are nucleic acids encoding the antigens and methods of producing the antigens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the antigen to the subject.
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公开(公告)号：US09695230B2
公开(公告)日：2017-07-04
申请号：US14363740
申请日：2012-12-10
发明人： Peter D. Kwong , Gary J. Nabel , Rebecca S. Rudicell , John Mascola , Mark Connors , Ivelin Georgiev , Jiang Zhu , Young Do Kwon , Tongqing Zhou , Yongping Yang , Baoshan Zhang , Gwo-Yu Chuang , Xueling Wu , Zhi-yong Yang , Wei Shi
IPC分类号： C07K16/10 , G01N33/569 , A61K39/42 , A61K45/06
CPC分类号： C07K16/1063 , A61K39/42 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/41 , C07K2317/565 , C07K2317/567 , C07K2317/72 , C07K2317/76 , C07K2317/92 , G01N33/56983 , G01N33/56988
摘要： Monoclonal neutralizing antibodies that specifically bind to HIV-1 gp120 and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV infection is disclosed.
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公开(公告)号：US10413527B2
公开(公告)日：2019-09-17
申请号：US16178277
申请日：2018-11-01
申请人： New York Blood Center, Inc. , The United States of America, as Represented by the Secretary, Department of Health and Human Services
IPC分类号： C07D207/30 , A61K31/40 , C07D403/12 , C07D405/14 , C07D417/12 , C07D417/14 , C07D207/34 , C07C25/00 , C07C233/01 , C07D277/20 , A61P31/18
摘要： Substituted phenylpyrrolecarboxamide compounds such as those represented by Formula A can be used in the treatment of HIV infection and related conditions.
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公开(公告)号：US11059808B2
公开(公告)日：2021-07-13
申请号：US15755009
申请日：2016-08-23
申请人： New York Blood Center, Inc. , The United States of America, As Represented By The Secretary, Department of Health and Human Services
IPC分类号： C07D403/12 , A61P31/18 , C07D207/34 , C07D241/04 , C07D401/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： Substituted phenylpyrrolecarboxamide compounds such as those represented by Formula A can be used in the treatment of HIV infection and related conditions.
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