公开(公告)号：US4973684A

公开(公告)日：1990-11-27

申请号：US203410

申请日：1988-06-07

申请人： Michihiko Ochiai ,  Taiiti Okada ,  Osamu Aki ,  Akira Morimoto ,  Kenji Kawakita ,  Yoshihiro Matsushita

发明人： Michihiko Ochiai ,  Taiiti Okada ,  Osamu Aki ,  Akira Morimoto ,  Kenji Kawakita ,  Yoshihiro Matsushita

IPC分类号： C07D277/20 ,  C07D277/32 ,  C07D277/34 ,  C07D277/38 ,  C07D277/40 ,  C07D277/46 ,  C07D277/48 ,  C07D499/46 ,  C07D499/58 ,  C07D501/20 ,  C07D501/24 ,  C07D501/34 ,  C07D501/36 ,  C07D501/46

CPC分类号： C07D277/20 ,  C07D277/34 ,  C07D277/40 ,  C07D277/46 ,  C07D277/48 ,  C07D277/587

摘要： Broad spectrum antibiotics are provided which are compounds of the formula: ##STR1## wherein R.sup.4 is a residue of a nucleophilic compound and R.sup.5 is hydroxyl or protected hydroxyl; or a pharmaceutically acceptable salt or ester thereof.

公开(公告)号：US4205180A

公开(公告)日：1980-05-27

申请号：US870932

申请日：1978-01-18

申请人： Michihiko Ochiai ,  Taiiti Okada ,  Osami Aki ,  Akira Morimoto ,  Kenji Kawakita ,  Yoshihiro Matsushita

发明人： Michihiko Ochiai ,  Taiiti Okada ,  Osami Aki ,  Akira Morimoto ,  Kenji Kawakita ,  Yoshihiro Matsushita

IPC分类号： C07D277/20 ,  C07D277/32 ,  C07D277/34 ,  C07D277/38 ,  C07D277/40 ,  C07D277/46 ,  C07D277/48 ,  C07D499/46 ,  C07D499/58 ,  C07D501/20 ,  C07D501/24 ,  C07D501/34 ,  C07D501/36 ,  C07D501/46 ,  C07C119/12

CPC分类号： C07D277/20 ,  C07D277/34 ,  C07D277/40 ,  C07D277/46 ,  C07D277/48 ,  C07D277/587

摘要： Novel cephem compounds of the formula; ##STR1## wherein R.sup.1 represents amino or hydroxyl group which may be protected, R.sup.2 represents amino or hydroxyl group or a group convertible into these groups, R.sup.3 represents hydrogen or methoxy group or a group convertible into methoxy group, R.sup.4 represents hydrogen or a residue of a nucleophilic compound and R.sup.8 represents hydrogen or a halogen, or a pharmaceutically acceptable salt or ester thereof, have strong antibiotic properties against a wide variety of microorganisms including gram-positive bacteria as well as gram-negative ones, especially by oral administration and can be used as therapeutic agent for various bacterial infections of animals including human beings.