公开(公告)号：US20230383285A1

公开(公告)日：2023-11-30

申请号：US18448725

申请日：2023-08-11

Applicant: 10x Genomics, Inc.

Inventor： Hanyoup Kim ,  David Sukovich ,  Layla Katiraee ,  Augusto Manuel Tentori

IPC: C12N15/10

CPC classification number: C12N15/1065

Abstract: Provided herein are methods for capturing a connected probe and/or a capture handle sequence to a capture domain of a capture probe.

公开(公告)号：US20230332247A1

公开(公告)日：2023-10-19

申请号：US18340501

申请日：2023-06-23

Applicant: 10x Genomics, Inc.

Inventor： Hardeep Pal Singh ,  David Sukovich ,  Seayar Mohabbat ,  Dongyao Li ,  Hanyoup Kim ,  Augusto Manuel Tentori

IPC: C12Q1/6886 ,  C12Q1/6834

CPC classification number: C12Q1/6886 ,  C12Q1/6834 ,  C12Q2600/158 ,  G01N2800/7028

Abstract: Provided herein are methods, compositions and systems for identifying spatial gene expression of analytes from glioblastoma derived tissue. The methods discloses herein include using templated ligation probe pairs to identify location of a disease proliferating region in a glioblastoma-derived sample by detecting analytes in the region and hybridizing a ligation product comprising the probe pairs to a capture probe on a spatial array.

公开(公告)号：US11739381B2

公开(公告)日：2023-08-29

申请号：US17867223

申请日：2022-07-18

Applicant: 10x Genomics, Inc.

Inventor： Jennifer Chew ,  Joseph Francis Shuga ,  Patrick Roelli ,  Denise Cheung ,  Alexander Hermes ,  Yifeng Yin ,  Naishitha Anaparthy ,  Ryo Hatori ,  Marlon Stoeckius ,  Rapolas Spalinskas ,  Anna-Maria Katsori ,  Cedric Uytingco ,  Mesruh Turkekul ,  David Sukovich ,  Christina Galonska ,  Aleksandra Jurek ,  Octavian Marian Bloju

IPC: C12Q1/6874 ,  C12N15/10 ,  C12Q1/6837

CPC classification number: C12Q1/6874 ,  C12N15/1065 ,  C12Q1/6837

Abstract: Provided herein are methods, compositions, and kits for preparing biological samples for multiplex spatial gene expression and proteomic analysis, such as determining a location of a nucleic acid analyte and a protein analyte in a biological sample.

公开(公告)号：US11618897B2

公开(公告)日：2023-04-04

申请号：US17871525

申请日：2022-07-22

Applicant: 10x Genomics, Inc.

Inventor： Hanyoup Kim ,  David Sukovich ,  Layla Katiraee ,  Augusto Manuel Tentori

IPC: C12Q1/6837 ,  C12N15/10

Abstract: Provided herein are methods for capturing a connected probe and/or a capture handle sequence to a capture domain of a capture probe.

公开(公告)号：US20220389504A1

公开(公告)日：2022-12-08

申请号：US17867223

申请日：2022-07-18

Applicant: 10x Genomics, Inc.

Inventor： Jennifer Chew ,  Joseph Francis Shuga ,  Patrick Roelli ,  Denise Cheung ,  Alexander Hermes ,  Yifeng Yin ,  Naishitha Anaparthy ,  Ryo Hatori ,  Marlon Stoeckius ,  Rapolas Spalinskas ,  Anna-Maria Katsori ,  Cedric Uytingco ,  Mesruh Turkekul ,  David Sukovich ,  Christina Galonska ,  Aleksandra Jurek ,  Octavian Marian Bloju

IPC: C12Q1/6874 ,  C12Q1/6837 ,  C12N15/10

Abstract: Provided herein are methods, compositions, and kits for preparing biological samples for multiplex spatial gene expression and proteomic analysis, such as determining a location of a nucleic acid analyte and a protein analyte in a biological sample.