公开(公告)号：US20250146057A1

公开(公告)日：2025-05-08

申请号：US19020235

申请日：2025-01-14

Applicant: 10x Genomics, Inc.

Inventor： Michael Schnall-Levin ,  Michael Ybarra Lucero ,  Tarjei Sigurd Mikkelsen ,  Patrik Stahl ,  Jonas Frisen ,  Maja Marklund ,  Enric Llorens Bobadilla ,  Eswar Prasad Ramachandran Iyer ,  Lucas Frenz ,  Augusto Manuel Tentori ,  Rajiv Bharadwaj ,  Linda Kvastad ,  Joakim Lundeberg ,  Eva Gracia Villacampa ,  Yifeng Yin ,  Zachary Bent ,  Jennifer Chew ,  Meghan L.F. Frey ,  Benjamin Hindson ,  Stephane Boutet ,  Katherine Pfeiffer

IPC: C12Q1/6837 ,  C12Q1/6841 ,  C12Q1/6874

Abstract: The present disclosure relates to materials and methods for spatially analyzing nucleic acids that have been fragmented with a transposase enzyme, alone or in combination with other types of analytes.

公开(公告)号：US20240417783A1

公开(公告)日：2024-12-19

申请号：US18785905

申请日：2024-07-26

Applicant: 10x Genomics, Inc.

Inventor： Jennifer Chew ,  Marlon Stoeckius

IPC: C12Q1/6837 ,  C12Q1/48 ,  G01N1/30

Abstract: Provided herein are methods and kits for binding of an analyte capture sequence to a capture domain of a capture probe.

公开(公告)号：US20230111225A1

公开(公告)日：2023-04-13

申请号：US18066007

申请日：2022-12-14

Applicant: 10x Genomics, Inc.

Inventor： Jennifer Chew ,  Zachary Bent ,  Alvaro J. Gonzalez Lozano

IPC: C12Q1/6874 ,  C12Q1/6825

Abstract: Provided herein are methods for resetting an array to which a biological sample has been applied that include treating the array with a set of biological sample removal conditions.

公开(公告)号：US20250129412A1

公开(公告)日：2025-04-24

申请号：US18972221

申请日：2024-12-06

Applicant: 10x Genomics, Inc.

Inventor： Cedric Uytingco ,  Zachary Bent ,  Eswar Prasad Ramachandran Iyer ,  Fernandino Valdecanas ,  Meghan L. F. Frey ,  Steven William Short ,  Yifeng Yin ,  Augusto Manuel Tentori ,  Rajiv Bharadwaj ,  David Maurice Cox ,  Jennifer Chew ,  Joakim Lundeberg ,  Felice Alessio Bava ,  Linda Kvastad ,  Andrew D. Price

IPC: C12Q1/6844 ,  B01L3/00 ,  B01L9/00 ,  C12N15/10 ,  C12Q1/6837 ,  C12Q1/6841 ,  C12Q1/6855 ,  C12Q1/6869 ,  C12Q1/6874 ,  C12Q1/6876 ,  C12Q1/6881 ,  G01N21/64 ,  G01N33/483 ,  G01N35/00 ,  G02B21/16 ,  G02B21/26 ,  G02B21/34 ,  G02B21/36

Abstract: A sample holder includes a first member featuring a first retaining mechanism configured to retain a first substrate that includes a sample, a second member featuring a second retaining mechanism configured to retain a second substrate that includes a reagent medium, and an alignment mechanism connected to at least one of the first and second members, and configured to align the first and second members such that the sample contacts at least a portion of the reagent medium when the first and second members are aligned.

公开(公告)号：US20240043908A1

公开(公告)日：2024-02-08

申请号：US18492362

申请日：2023-10-23

Applicant: 10x Genomics, Inc.

Inventor： Jennifer Chew ,  David Michael Patterson

IPC: C12Q1/6806

CPC classification number: C12Q1/6806

Abstract: Provided herein are methods, compositions, and kits for determining a location of a target analyte in a biological sample that include the use of terminal deoxynucleotidyl transferase.

公开(公告)号：US20230069046A1

公开(公告)日：2023-03-02

申请号：US17971174

申请日：2022-10-21

Applicant: 10x Genomics, Inc.

Inventor： Jennifer Chew ,  Yifeng Yin ,  Layla Katiraee

IPC: C12Q1/6841

Abstract: Provided herein are methods for capturing an analyte from a first region of interest of a biological sample on a substrate, where the biological sample comprises the first region of interest and a second region, and where the method includes contacting the second region with a sealant in order to create a hydrophobic seal thereby preventing an interaction between an analyte from the second region with a capture domain of a capture probe.

公开(公告)号：US20220326251A1

公开(公告)日：2022-10-13

申请号：US17738808

申请日：2022-05-06

Applicant: 10x Genomics, Inc.

Inventor： Cedric Uytingco ,  James Michael Chell ,  Marlon Stoeckius ,  Albert Kim ,  Dulce Ovando Morales ,  Andrej Hartnett ,  Yifeng Yin ,  Jennifer Chew

IPC: G01N33/68 ,  C12N15/10 ,  C12Q1/6804 ,  G01N33/58 ,  C12Q1/6874 ,  G01N1/30 ,  G01N21/64

Abstract: Provided herein are methods for preparing biological samples for spatial proteomic analysis, methods of determining a location of a protein analyte in a biological sample, and methods of determining a location of a protein analyte and a nucleic acid analyte in a biological sample.

公开(公告)号：US20220098661A1

公开(公告)日：2022-03-31

申请号：US17548047

申请日：2021-12-10

Applicant: 10x Genomics, Inc.

Inventor： Jennifer Chew ,  Zachary Bent ,  Alvaro J. Gonzalez Lozano

IPC: C12Q1/6874 ,  C12Q1/6825

Abstract: Provided herein are methods for resetting an array to which a biological sample has been applied that include treating the array with a set of biological sample removal conditions.

公开(公告)号：US20250155446A1

公开(公告)日：2025-05-15

申请号：US19020590

申请日：2025-01-14

Applicant: 10x Genomics, Inc.

Inventor： Cedric Uytingco ,  James Michael Chell ,  Marlon Stoeckius ,  Albert Dale Kim ,  Dulce Ovando Morales ,  Andrej Hartnett ,  Yifeng Yin ,  Jennifer Chew

IPC: G01N33/68 ,  C12N15/10 ,  C12Q1/6804 ,  C12Q1/6874 ,  G01N1/30 ,  G01N21/64 ,  G01N33/58

Abstract: Provided herein are methods for preparing biological samples for spatial proteomic analysis, methods of determining a location of a protein analyte in a biological sample, and methods of determining a location of a protein analyte and a nucleic acid analyte in a biological sample.

公开(公告)号：US20250002982A1

公开(公告)日：2025-01-02

申请号：US18344339

申请日：2023-06-29

Applicant: 10x Genomics, Inc.

Inventor： Marlon Stoeckius ,  James Michael Chell ,  Cedric Uytingco ,  Jennifer Chew ,  Felice Alessio Bava

IPC: C12Q1/6841 ,  C12Q1/6874

Abstract: The present disclosure relates to determining the location of analytes in fixed biological samples.