公开(公告)号：US10670605B2

公开(公告)日：2020-06-02

申请号：US15331745

申请日：2016-10-21

Applicant: The Scripps Research Institute

Inventor： Benjamin F. Cravatt ,  Keriann M. Backus ,  Bruno E. Correia ,  Megan M. Blewett ,  John R. Teijaro

IPC: G01N33/68 ,  C40B60/00 ,  C12N9/04 ,  C12N9/10 ,  C12N9/64 ,  G01N33/50

Abstract: Disclosed herein are methods, compositions, probes, polypeptides, assays, and kits for identifying a cysteine containing protein as a binding target for a small molecule fragment. Also disclosed herein are methods, compositions, and probes for mapping a biologically active cysteine site on a protein and screening a small molecule fragment for interaction with a cysteine containing protein.

公开(公告)号：US20150080364A1

公开(公告)日：2015-03-19

申请号：US14383076

申请日：2013-03-15

Applicant: Abide Therapeutics, Inc. ,  The Scripps Research Insititute

Inventor： Justin S. Cisar ,  Cheryl A. Grice ,  Todd K. Jones ,  Dong-Hui Wang ,  Olivia Weber ,  Benjamin F. Cravatt ,  Micah J. Niphakis ,  Armand Cognetta ,  Jae Won Chang

IPC: C07D207/46 ,  C07D401/12 ,  C07D487/04 ,  C07D491/107 ,  C07D471/04 ,  C07D405/14 ,  C07D413/12

CPC classification number: C07D207/46 ,  C07D209/48 ,  C07D233/80 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D491/08 ,  C07D491/107 ,  C07D498/08

Abstract: Provided herein are carbamate compounds which may be useful in the treatment of for example, pain, solid tumors and/or obesity.

Abstract translation: 本文提供了可用于治疗例如疼痛，实体瘤和/或肥胖症的氨基甲酸酯化合物。