公开(公告)号：US09957330B2

公开(公告)日：2018-05-01

申请号：US14442603

申请日：2013-12-19

Applicant: AFFIBODY AB

Inventor： Lars Abrahmsén ,  Ingmarie Höidén-Guthenberg ,  Elin Gunneriusson

IPC: C07K16/40 ,  C07K16/30 ,  C07K14/47 ,  C07K14/435

CPC classification number: C07K16/40 ,  C07K14/435 ,  C07K14/47 ,  C07K16/30 ,  C07K2317/92 ,  C07K2318/20

Abstract: The present disclosure relates to a class of engineered polypeptides having a binding affinity for carbonic anhydrase IX (CAIX), and provides a CAIX binding polypeptide comprising the sequence EX2X3X4AX6X7EIX10X11LPN LX16X17X18QX20 X21AFIX25X26LWD. The present disclosure also relates to the use of such a CAIX binding polypeptide as a diagnostic, prognostic agent and/or therapeutic agent.

公开(公告)号：US20170260238A1

公开(公告)日：2017-09-14

申请号：US15510900

申请日：2015-09-17

Applicant: Affibody AB

Inventor： Lars Abrahmsén ,  Caroline Ekblad ,  Elin Gunneriusson ,  Torbjörn Gräslund ,  Johan Seijsing ,  John Löfblom ,  Malin Lindborg ,  Fredrik Frejd ,  Lindvi Gudmundsdotter

IPC: C07K14/00

CPC classification number: C07K14/00 ,  A61K38/00 ,  C07K14/31 ,  C07K14/70535 ,  C07K14/70539 ,  C07K2319/00 ,  C07K2319/30 ,  C07K2319/74

Abstract: The present disclosure relates to dimers of engineered polypeptides having a binding affinity for the neonatal Fc receptor FcRn, and provides an FcRn binding dimer, comprising a first monomer unit, a second monomer unit and an amino acid linker, wherein said first and second monomer unit search comprises an FcRn binding motif. Said FcRn binding dimer binds FcRn with higher capacity compared to said first monomer unit or second monomer unit alone. The present disclosure also relates to the use of said FcRn binding dimer as an agent for modifying pharmacokinetic and pharmacodynamic properties and as a therapeutic agent.

公开(公告)号：US20160199521A1

公开(公告)日：2016-07-14

申请号：US15083424

申请日：2016-03-29

Applicant: General Electric Company ,  AFFIBODY AB

Inventor： Faisal Ahmed Syud ,  Brian Duh-Lan Lee ,  Rong Zhang ,  Peter Brian Iveson ,  Paul Schaffer ,  Tove Simonsson ,  Elin Gunneriusson ,  Fredrik Frejd ,  Lars Abrahmsen ,  Joachim Feldwisch ,  Nina Herne ,  Christofer Lendel

IPC: A61K51/08

CPC classification number: A61K51/088 ,  C07K14/71

Abstract: Imaging agents comprising an isolated polypeptide conjugated with a radionucleide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.

Abstract translation: 包含与放射性核素和螯合剂缀合的分离的多肽的成像剂; 其中所述分离的多肽特异性结合HER2或其变体; 以及制备和使用这些成像剂的方法。

公开(公告)号：US20160031967A1

公开(公告)日：2016-02-04

申请号：US14776319

申请日：2014-03-17

Applicant: AFFIBODY AB

Inventor： Caroline Ekblad ,  Elin Gunneriusson ,  Malin Lindborg ,  Lars Abrahmsen ,  John Löfblom ,  Torbjörn Gräslund ,  Johan Seijsing

IPC: C07K14/745

CPC classification number: C07K14/745 ,  A61K38/00 ,  C07K14/31 ,  C07K14/435 ,  C07K14/70535 ,  C07K14/70539 ,  C07K2319/74

Abstract: The present disclosure relates to a class of engineered polypeptides having a binding affinity for the neonatal Fc receptor (in the following referred to as FcRn), and provides an FcRn binding polypeptide comprising the sequence EX2X3X4AX6X7 EIRWLPNL X16X17X18QRX21 AFIX25X26LX28X29 (SEQ ID NO: 1075). The present disclosure also relates to the use of such an FcRn binding polypeptide as an agent for modifying pharmacokinetic and pharmacodynamic properties and as a therapeutic agent.

Abstract translation: 本公开涉及对新生儿Fc受体具有结合亲和力的一类工程化多肽（在下文中称为FcRn），并提供包含序列EX2X3X4AX6X7EIRWLPNL X16X17X18QRX21AFIX25X26LX28X29（SEQ ID NO：1075）的FcRn结合多肽。 本公开还涉及这种FcRn结合多肽作为用于改变药代动力学和药效学性质的试剂以及作为治疗剂的用途。