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公开(公告)号：US11505576B2
公开(公告)日：2022-11-22
申请号：US16977625
申请日：2019-03-12
Applicant: AFFIBODY AB
Inventor： Caroline Ekblad , Elin Gunneriusson , Sophia Hober , Sarah Lindbo
Abstract: The disclosure provides a population of polypeptide variants based on a common scaffold, each polypeptide in the population comprising the scaffold amino acid sequence Xsc1AELDXsc2Xsc3GVG AXXIKXIXsc4XA XXVEXVQXXK QXILAX. The disclosure also provides methods for selecting and identifying polypeptides from the population, as well as such polypeptides themselves.
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公开(公告)号：US20190284241A1
公开(公告)日：2019-09-19
申请号：US16377722
申请日：2019-04-08
Applicant: Affibody AB
Inventor： Lars Abrahmsén , Caroline Ekblad , Elin Gunneriusson , Torbjörn Gräslund , Johan Seijsing , John Löfblom , Malin Lindborg , Fredrik Frejd , Lindvi Gudmundsdotter
IPC: C07K14/00 , C07K14/735 , C07K14/74 , C07K14/31
Abstract: The present disclosure relates to dimers of engineered polypeptides having a binding affinity for the neonatal Fc receptor FcRn, and provides an FcRn binding dimer, comprising a first monomer unit, a second monomer unit and an amino acid linker, wherein the first and second monomer units each comprises an FcRn binding motif. The FcRn binding dimer binds FcRn with higher capacity compared to the first monomer unit or second monomer unit alone. The present disclosure also relates to the use of the FcRn binding dimer as an agent for modifying pharmacokinetic and pharmacodynamic properties and as a therapeutic agent.
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公开(公告)号：US20180118807A1
公开(公告)日：2018-05-03
申请号：US15842178
申请日：2017-12-14
Applicant: AFFIBODY AB
Inventor： Caroline Ekblad , Elin Gunneriusson , Malin Lindborg , Lars Abrahmsen , John Löfblom , Torbjörn Gräslund , Johan Seijsing
IPC: C07K14/745 , C07K14/735 , C07K14/31 , C07K14/74 , C07K14/435 , A61K38/00
Abstract: The present disclosure relates to a class of engineered polypeptides having a binding affinity for the neonatal Fc receptor (in the following referred to as FcRn), and provides an FcRn binding polypeptide comprising the sequence EX2 X3 X4 AX6 X7 EIRWLPNL X16X17 X18 QRX21 AFIX25 X26LX28 X29. The present disclosure also relates to the use of such an FcRn binding polypeptide as an agent for modifying pharmacokinetic and pharmacodynamic properties and as a therapeutic agent.
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公开(公告)号：US20210170057A1
公开(公告)日：2021-06-10
申请号：US17117697
申请日：2020-12-10
Applicant: General Electric Company , Affibody AB
Inventor： Faisal Ahmed Syud , Brian Duh-Lan Lee , Rong Zhang , Peter Brian Iveson , Paul Schaffer , Tove Simonsson , Elin Gunneriusson , Fredrik Frejd , Lars Abrahmsen , Joachim Feldwisch , Nina Herne , Christofer Lendel
Abstract: Imaging agents comprising an isolated polypeptide conjugated with a radionucleide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.
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公开(公告)号：US10562955B2
公开(公告)日：2020-02-18
申请号：US15842178
申请日：2017-12-14
Applicant: AFFIBODY AB
Inventor： Caroline Ekblad , Elin Gunneriusson , Malin Lindborg , Lars Abrahmsen , John Löfblom , Torbjörn Gräslund , Johan Seijsing
IPC: C07K14/745 , C07K14/735 , C07K14/31 , C07K14/74 , C07K14/435 , A61K38/00
Abstract: The present disclosure relates to a class of engineered polypeptides having a binding affinity for the neonatal Fc receptor (in the following referred to as FcRn), and provides an FcRn binding polypeptide comprising the sequence EX2 X3 X4 AX6 X7 EIRWLPNL X16X17 X18 QRX21 AFIX25 X26LX28 X29. The present disclosure also relates to the use of such an FcRn binding polypeptide as an agent for modifying pharmacokinetic and pharmacodynamic properties and as a therapeutic agent.
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Patent Agency Ranking
公开(公告)号：US20190262481A1
公开(公告)日：2019-08-29
申请号：US16145115
申请日：2018-09-27
Applicant: GENERAL ELECTRIC COMPANY , AFFIBODY AB
Inventor： Faisal Ahmed Syud , Brian Duh-Lan Lee , Rong Zhang , Peter Brian Iveson , Paul Schaffer , Tove Simonsson , Elin Gunneriusson , Fredrik Frejd , Lars Abrahmsen , Joachim Feldwisch , Nina Herne , Christofer Lendel
Abstract: Imaging agents comprising an isolated polypeptide conjugated with a radionuclide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.
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公开(公告)号：US10159760B2
公开(公告)日：2018-12-25
申请号：US15083424
申请日：2016-03-29
Applicant: General Electric Company , AFFIBODY AB
Inventor： Faisal Ahmed Syud , Brian Duh-Lan Lee , Rong Zhang , Peter Brian Iveson , Paul Schaffer , Tove Simonsson , Elin Gunneriusson , Fredrik Frejd , Lars Abrahmsen , Joachim Feldwisch , Nina Herne , Christofer Lendel
Abstract: Imaging agents comprising an isolated polypeptide conjugated with a radionucleide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.
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公开(公告)号：US20180312565A1
公开(公告)日：2018-11-01
申请号：US15770956
申请日：2016-10-28
Applicant: AFFIBODY AB
Inventor： Elisabet Wahlberg , Elin Gunneriusson
IPC: C07K14/705 , C07K14/47 , A61P35/00 , A61K47/42
CPC classification number: C07K14/70532 , A61K38/00
Abstract: The present disclosure relates to a class of engineered polypeptides having a binding affinity for programmed death-ligand 1 (PD-L1), and provides a PD-L1 binding polypeptide comprising the sequence ERNX4AAX7EIL X11LPNLX16X17X18QX20 WAFIWX26LX28D. The present disclosure also relates to the use of such a PD-L1 binding polypeptide as a therapeutic, prognostic and/or diagnostic agent.
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公开(公告)号：US09873729B2
公开(公告)日：2018-01-23
申请号：US14776319
申请日：2014-03-17
Applicant: AFFIBODY AB
Inventor： Caroline Ekblad , Elin Gunneriusson , Malin Lindborg , Lars Abrahmsen , John Löblom , Torbjörn Gräslund , Johan Seijsing
IPC: C07K14/745 , C07K14/735 , C07K14/74 , C07K14/31 , C07K14/435 , A61K38/00
Abstract: The present disclosure relates to a class of engineered polypeptides having a binding affinity for the neonatal Fc receptor (in the following referred to as FcRn), and provides an FcRn binding polypeptide comprising the sequence EX2X3X4AX6X7 EIRWLPNL X16X17X18QRX21 AFIX25X26LX28X29 (SEQ ID NO: 1075). The present disclosure also relates to the use of such an FcRn binding polypeptide as an agent for modifying pharmacokinetic and pharmacodynamic properties and as a therapeutic agent.
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公开(公告)号：US10894097B2
公开(公告)日：2021-01-19
申请号：US16145115
申请日：2018-09-27
Applicant: GENERAL ELECTRIC COMPANY , AFFIBODY AB
Inventor： Faisal Ahmed Syud , Brian Duh-Lan Lee , Rong Zhang , Peter Brian Iveson , Paul Schaffer , Tove Simonsson , Elin Gunneriusson , Fredrik Frejd , Lars Abrahmsen , Joachim Feldwisch , Nina Herne , Christofer Lendel
Abstract: Imaging agents comprising an isolated polypeptide conjugated with a radionuclide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.
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