公开(公告)号：US20180177767A1

公开(公告)日：2018-06-28

申请号：US15849905

申请日：2017-12-21

Applicant: AMGEN INC.

Inventor： Brian Alan LANMAN ,  Victor J. CEE ,  Alexander J. PICKRELL ,  Anthony B. REED ,  Kevin C. YANG ,  David John KOPECKY ,  Hui-Ling WANG ,  Patricia LOPEZ ,  Kate ASHTON ,  Shon BOOKER ,  Christopher M. TEGLEY

IPC: A61K31/428 ,  A61K31/496 ,  A61K31/519 ,  A61K31/517 ,  A61K31/5025 ,  A61K31/502 ,  A61P35/00

Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

公开(公告)号：US20130273004A1

公开(公告)日：2013-10-17

申请号：US13829288

申请日：2013-03-14

Applicant: Amgen, Inc.

Inventor： Guoqing CHEN ,  Jeffrey A. ADAMS ,  Jean E. BEMIS ,  Shon BOOKER ,  Guolin CAI ,  Lucian V. DIPIETRO ,  Celia DOMINGUEZ ,  Daniel ELBAUM ,  Julie GERMAIN ,  Stephanie D. GEUNS-MEYER ,  Michael K. HANDLEY ,  Qi HUANG ,  Joseph L. KIM ,  Tae-Seong KIM ,  Alexander S. KISELYOV ,  Xiaohu OUYANG ,  Vinod F. PATEL ,  Leon M. SMITH, II ,  Markian M. STEC ,  Andrew TASKER ,  Ning XI ,  Shimin XU ,  Chester YUAN ,  Michael CROGHAN

IPC: C07D213/82 ,  C07D401/12 ,  A61K31/4709 ,  C07D409/00 ,  A61K31/4725 ,  C07D417/14 ,  C07D413/14 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/4439 ,  C07D401/14 ,  A61K31/4545 ,  A61K31/506 ,  C07D405/12 ,  A61K31/443 ,  A61K31/538 ,  A61K31/444

CPC classification number: C07D213/82 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/538 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/00 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

Abstract: Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like.

Abstract translation: 所选择的杂环化合物对于预防和治疗诸如血管生成介导的疾病等疾病是有效的。 本发明包括新型化合物，类似物，前药及其药学上可接受的衍生物，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。