中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

27 records (took 0.051 seconds)

    DUAL SPECIFICITY ANTIBODIES AND METHODS OF MAKING AND USING
    22.
    发明申请
    DUAL SPECIFICITY ANTIBODIES AND METHODS OF MAKING AND USING 审中-公开
    双重特异性抗体及其制备和使用方法

    公开(公告)号：US20150175694A1

    公开(公告)日：2015-06-25

    申请号：US14639985

    申请日：2015-03-05

    Applicant: AbbVie Inc.

    Inventor： Albert COLLINSON ,  George Avgerinos ,  Richard DIXON ,  Tariq GHAYUR ,  Zehra KAYMAKCALAN

    IPC: C07K16/24

    CPC classification number: C07K16/245 ,  A61K47/6845 ,  A61K2039/505 ,  C07K14/545 ,  C07K16/46 ,  C07K16/468 ,  C07K2317/10 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/76 ,  G01N33/6869

    Abstract: Antibodies having dual specificity for two different but structurally related antigens are provided. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have dual specificity for IL-1α and IL-1β and neutralize IL-1α and IL-1β activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting two different but structurally related antigens (e.g., IL-1α and IL-1β) and for inhibiting the activity of the antigens, e.g., in a human subject suffering from a disorder in which IL-1α and/or IL-1β activity is detrimental.

    Abstract translation: 提供了对两种不同但结构相关抗原具有双重特异性的抗体。 抗体可以是例如完全是人抗体，重组抗体或单克隆抗体。 优选的抗体对IL-1α和IL-1＆bgr具有双重特异性; 并中和IL-1α和IL-1和bgr; 体外和体内活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 还提供了制备方法和使用本发明抗体的方法。 本发明的抗体或抗体部分可用于检测两种不同但结构相关的抗原（例如IL-1α和IL-1和bgr），并且用于抑制抗原的活性，例如在患有 其中IL-1α和/或IL-1和bgr的病症 活动是有害的。

Patent Agency Ranking