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公开(公告)号：US20100285108A1
公开(公告)日：2010-11-11
申请号：US12661628
申请日：2010-03-18
申请人： Andrea Pfeifer , Andreas Muhs , Maria Pihlgren
发明人： Andrea Pfeifer , Andreas Muhs , Maria Pihlgren
IPC分类号： A61K9/127 , A61K39/00 , A61K39/385 , A61P25/28 , A61P37/04 , A61P31/18 , A61P25/00 , A61P25/16
CPC分类号： C07K14/4711 , A61K39/0007 , A61K2039/55555 , A61K2039/6018
摘要： The present invention is related to methods for the therapeutic use in the treatment of diseases and disorders where T-helper independent antibody responses are beneficial. In particular, the present invention relates to a method wherein these diseases and disorders above are treated in immunocompromised or autoimmune diseased animals or humans. Even more particular the present invention relates to the treatment of Alzheimer's disease in immunocompromised or autoimmune diseased animals or humans or where inflammatory reactions need to be specifically avoided.
摘要翻译： 本发明涉及治疗用于治疗T辅助者独立抗体应答有益的疾病和病症的方法。 特别地，本发明涉及一种方法，其中在免疫受损或自身免疫疾病的动物或人中治疗上述这些疾病和病症。 更具体地，本发明涉及在免疫受损或自身免疫疾病的动物或人中治疗阿尔茨海默病，或者需要特别避免炎症反应。
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公开(公告)号：US09304138B2
公开(公告)日：2016-04-05
申请号：US13500608
申请日：2011-10-07
CPC分类号： C07K16/18 , A61K39/0005 , A61K2039/505 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N2800/2821 , G01N2800/52
摘要： The present invention relates to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with neurofibrillary tangles. In particular, the invention relates to antibodies, which specifically recognize and bind to phosphorylated pathological protein tau-conformers and to methods and compositions involving said antibodies for the therapeutic and diagnostic use in the treatment of tauopathies including Alzheimer's Disease (AD).
摘要翻译： 本发明涉及用于治疗和诊断用于治疗由神经原纤维缠结引起或与神经原纤维缠结有关的疾病和病症的方法和组合物。 特别地，本发明涉及特异性识别和结合磷酸化病理蛋白质tau-构象异构体的抗体以及涉及治疗和诊断用于治疗包括阿尔茨海默病（AD）在内的tau蛋白病的治疗和诊断用途的所述抗体的方法和组合物。
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23.发明授权Pharmaceutical composition of an antigenic tau peptide reconstituted in a liposome and related antibodies and cell lines 有权在脂质体中重构的抗原性tau肽的药物组合物和相关的抗体和细胞系公开(公告)号：US08647631B2
公开(公告)日：2014-02-11
申请号：US13262793
申请日：2010-04-01
申请人： Andrea Pfeifer , Andreas Muhs , Fred Van Leuven , Maria Pihlgren
发明人： Andrea Pfeifer , Andreas Muhs , Fred Van Leuven , Maria Pihlgren
IPC分类号： A61K39/385 , A61K38/10 , A61K39/00 , A61K9/127
CPC分类号： C07K16/18 , A61K39/0005 , A61K2039/505 , A61K2039/6087 , C07K14/4711 , C07K2317/24 , G01N33/53 , G01N33/6896 , G01N2333/47 , G01N2800/2821 , G01N2800/52
摘要： The present invention is related to methods and pharmaceutical compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with neurofibrillary tangles. In particular, the invention relates to pharmaceutical composition comprising an antigenic peptide, particularly an antigenic phospho-peptide mimicking a major pathological phospho-epitope of protein tau, for the therapeutic and diagnostic use in the treatment of tauopathies including Alzheimer's Disease.
摘要翻译： 本发明涉及用于治疗和诊断用于治疗由神经原纤维缠结引起或与神经原纤维缠结有关的疾病和病症的药物组合物。 特别地，本发明涉及药物组合物，其包含抗原肽，特别是模拟蛋白质tau的主要病理学磷酸化表位的抗原性磷酸肽，用于治疗和诊断用于治疗包括阿尔茨海默氏病的tau蛋白病。
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公开(公告)号：US20120183599A1
公开(公告)日：2012-07-19
申请号：US13262793
申请日：2010-04-01
申请人： Andrea Pfeifer , Andreas Muhs , Fred Van Leuven , Maria Pihlgren
发明人： Andrea Pfeifer , Andreas Muhs , Fred Van Leuven , Maria Pihlgren
IPC分类号： A61K9/127 , C07K4/12 , C07K14/47 , C07K7/08 , C07K7/06 , C07K16/18 , A61K39/00 , A61P37/04 , A61P25/28 , A61P25/00 , A61P25/16 , A61K39/395 , C12N5/16 , G01N33/566 , G01N33/577 , C07K2/00
CPC分类号： C07K16/18 , A61K39/0005 , A61K2039/505 , A61K2039/6087 , C07K14/4711 , C07K2317/24 , G01N33/53 , G01N33/6896 , G01N2333/47 , G01N2800/2821 , G01N2800/52
摘要： The present invention is related to methods and pharmaceutical compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with neurofibrillary tangles. In particular, the invention relates to pharmaceutical composition comprising an antigenic peptide, particularly an antigenic phospho-peptide mimicking a major pathological phospho-epitope of protein tau, for the therapeutic and diagnostic use in the treatment of tauopathies including Alzheimer's Disease.
摘要翻译： 本发明涉及用于治疗和诊断用于治疗由神经原纤维缠结引起或与神经原纤维缠结有关的疾病和病症的药物组合物。 特别地，本发明涉及药物组合物，其包含抗原肽，特别是模拟蛋白质tau的主要病理学磷酸化表位的抗原性磷酸肽，用于治疗和诊断用于治疗包括阿尔茨海默氏病的tau蛋白病。
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