公开(公告)号：USD439029S1

公开(公告)日：2001-03-20

申请号：US29105557

申请日：1999-05-25

申请人： David Goldman

设计人： David Goldman

公开(公告)号：US20130216615A1

公开(公告)日：2013-08-22

申请号：US13760916

申请日：2013-02-06

申请人： David Goldman

发明人： David Goldman

IPC分类号： A61K31/225 ,  A61K45/06 ,  A61K31/60

CPC分类号： A61K31/225 ,  A61K9/16 ,  A61K9/2054 ,  A61K9/2072 ,  A61K9/2833 ,  A61K9/2846 ,  A61K9/4808 ,  A61K31/60 ,  A61K31/616 ,  A61K45/06 ,  A61K2300/00

摘要： Provided herein are compositions containing compounds, or pharmaceutically acceptable salts, that metabolize to monomethyl fumarate with certain pharmacokinetic parameters and methods for treating, prophylaxis, or amelioration of neurodegenerative diseases including multiple sclerosis using such compositions in a subject, wherein if the compositions contain dimethyl fumarate, the total amount of dimethyl fumarate in the compositions ranges from about 43% w/w to about 95% w/w.

摘要翻译： 本文提供了含有化合物或药学上可接受的盐的组合物，其具有某些药代动力学参数和用于治疗，预防或改善神经变性疾病（包括使用该受试者中的这种组合物的多发性硬化症）的方法，其中如果组合物含有富马酸二甲酯 ，组合物中富马酸二甲酯的总量为约43％w / w至约95％w / w。

公开(公告)号：US20070118245A1

公开(公告)日：2007-05-24

申请号：US11556008

申请日：2006-11-02

申请人： David Goldman ,  Nirav Patel ,  Mingkui Song

发明人： David Goldman ,  Nirav Patel ,  Mingkui Song

IPC分类号： D05C5/02

CPC分类号： D05B19/08 ,  D05B19/02 ,  D05B19/12

摘要： An example printer driver system and method disclosed herein includes determining a set of line segments corresponding to received image information, determining a first polygon from a first subset of the set of line segments, determining a second polygon from a second subset of the set of line segments, determining that a first line segment in the first subset and a second line segment in the second subset are collinear, removing the first line segment from the set of line segments, subtracting the first line segment from the second line segment to form a third line segment, replacing the second line segment in the set of line segments with the third line segment, determining a path corresponding to the set of line segments, determining a set of coordinates corresponding to the path, and instructing an embroidery machine to stitch the path in a substrate using the set of coordinates.

摘要翻译： 本文公开的示例性打印机驱动器系统和方法包括确定与接收到的图像信息相对应的一组线段，从该组线段的第一子集中确定第一多边形，从该组线的第二子集中确定第二多边形 确定第一子集中的第一线段和第二子集中的第二线段共线，从线组集合去除第一线段，从第二线段减去第一线段以形成第三线段 将所述线段组中的第二线段替换为第三线段，确定与所述线段组对应的路径，确定与所述路径相对应的一组坐标，并指示绣花机缝合所述路线 在使用该坐标系的基板中。

公开(公告)号：US06762294B2

公开(公告)日：2004-07-13

申请号：US09930589

申请日：2001-08-15

申请人： David Goldman ,  Nakao Iwata ,  Marc A. Schuckit

发明人： David Goldman ,  Nakao Iwata ,  Marc A. Schuckit

IPC分类号： C07H2104

CPC分类号： C07K14/70571

摘要： Compositions and methods based on a polymorphism in the gene encoding the &agr;6 subunit of the human GABAA neurotransmitter receptor are disclosed. This polymorphism results in the substitution of a serine residue for a proline residue ordinarily present at amino acid position 385 of the &agr;6 polypeptide sequence. Significantly, the polymorphism was associated with decreased sensitivity to ethanol and benzodiazepine drugs.

摘要翻译： 公开了基于编码人GABAA神经递质受体的α6亚基的基因的多态性的组合物和方法。 该多态性导致丝氨酸残基取代通常存在于α6多肽序列的氨基酸位置385处的脯氨酸残基。 显着地，多态性与乙醇和苯二氮卓类药物的敏感性降低有关。

公开(公告)号：US09682043B2

公开(公告)日：2017-06-20

申请号：US11008034

申请日：2004-12-09

申请人： David Goldman

发明人： David Goldman

IPC分类号： A61K9/14 ,  A61K8/63 ,  A61K9/48 ,  A61K9/10

CPC分类号： A61K9/145 ,  A61K8/63 ,  A61K9/10 ,  A61K9/146 ,  A61K9/148 ,  A61K9/4858

摘要： This invention pertains to a method of preparing mixed phase co-crystals of active agents with one or more materials that allows the modification of the active agent to a new physical/crystal form with unique properties useful for the delivery of the active agent, as well as compositions comprising the mixed phase co-crystals.

公开(公告)号：US08178876B2

公开(公告)日：2012-05-15

申请号：US10595384

申请日：2004-04-30

申请人： Christopher Hess ,  David Goldman

发明人： Christopher Hess ,  David Goldman

IPC分类号： H01L23/58

CPC分类号： H01L22/34 ,  G01R31/2884 ,  H01L2924/0002 ,  H01L2924/3011 ,  H01L2924/00

摘要： A test chip comprises at least one level having an array of regions. Each region is capable of including at least one test structure. At least some of the regions include respective test structures. The level has a plurality of driver lines that provide input signals to the test structures. The level has a plurality of receiver lines that receive output signals from the test structures. The level has a plurality of devices for controlling current flow. Each test structure is connected to at least one of the driver lines with a first one of the devices in between. Each test structure is connected to at least one of the receiver lines with a second one of the devices in between, so that each of the test structures can be individually addressed for testing using the driver lines and receiver lines.

摘要翻译： 测试芯片包括具有区域阵列的至少一个级别。 每个区域能够包括至少一个测试结构。 至少一些区域包括相应的测试结构。 电平具有多个驱动线，其向测试结构提供输入信号。 电平具有接收来自测试结构的输出信号的多个接收线。 该电平具有用于控制电流的多个装置。 每个测试结构都与至少一个驱动器线连接，其中的第一个设备之间。 每个测试结构与至少一个接收器线路连接，其间具有第二个设备，使得每个测试结构可以被单独寻址，以便使用驱动器线路和接收器线路进行测试。

公开(公告)号：US20090037131A1

公开(公告)日：2009-02-05

申请号：US10595384

申请日：2004-04-30

申请人： Christopher Hess ,  David Goldman

发明人： Christopher Hess ,  David Goldman

IPC分类号： G06F19/00

CPC分类号： H01L22/34 ,  G01R31/2884 ,  H01L2924/0002 ,  H01L2924/3011 ,  H01L2924/00

摘要： A test chip comprises at least one level having an array of regions. Each region is capable of including at least one test structure. At least some of the regions include respective test structures. The level has a plurality of driver lines that provide input signals to the test structures. The level has a plurality of receiver lines that receive output signals from the test structures. The level has a plurality of devices for controlling current flow. Each test structure is connected to at least one of the driver lines with a first one of the devices in between. Each test structure is connected to at least one of the receiver lines with a second one of the devices in between, so that each of the test structures can be individually addressed for testing using the driver lines and receiver lines.

摘要翻译： 测试芯片包括具有区域阵列的至少一个级别。 每个区域能够包括至少一个测试结构。 至少一些区域包括相应的测试结构。 电平具有多个驱动线，其向测试结构提供输入信号。 电平具有接收来自测试结构的输出信号的多个接收线。 该电平具有用于控制电流的多个装置。 每个测试结构都与至少一个驱动器线连接，其中的第一个设备之间。 每个测试结构与至少一个接收器线路连接，其间具有第二个设备，使得每个测试结构可以被单独寻址，以便使用驱动器线路和接收器线路进行测试。

公开(公告)号：US20070254288A1

公开(公告)日：2007-11-01

申请号：US11584449

申请日：2006-10-20

申请人： Clifford Woolf ,  Michael Costigan ,  Mitchell Max ,  Inna Belfer ,  Steven Atlas ,  Albert Kingman ,  Tianxia Wu ,  David Goldman

发明人： Clifford Woolf ,  Michael Costigan ,  Mitchell Max ,  Inna Belfer ,  Steven Atlas ,  Albert Kingman ,  Tianxia Wu ,  David Goldman

IPC分类号： C12Q1/02 ,  C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q1/34 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172 ,  G01N2333/978 ,  G01N2800/28 ,  G01N2800/32

摘要： Disclosed herein are methods for determining whether a subject possesses altered pain sensitivity an altered risk of developing acute or chronic pain, or diagnosing a tetrahydrobiopterin (BH4)-related disorder or a propensity thereto. These methods are based on the discovery of GCH1 and KCNS1 allelic variants that are associated with altered pain sensitivity and altered risk of developing acute or chronic pain, and the discovery that a GCH1 “pain protective haplotype” is associated with decreased upregulation of BH4 synthesis in treated leukocytes.

摘要翻译： 本文公开了用于确定受试者是否具有改变的疼痛敏感性的改变的发生急性或慢性疼痛的风险或诊断四氢生物蝶呤（BH4）相关病症或其倾向的方法。 这些方法是基于发现与改变的疼痛敏感性和改变的发生急性或慢性疼痛的风险相关的GCH1和KCNS1等位基因变体，以及发现GCH1“疼痛保护性单倍型”与BH4合成的上调减少有关 治疗白细胞。

公开(公告)号：US20070235668A1

公开(公告)日：2007-10-11

申请号：US11278071

申请日：2006-03-30

申请人： David Goldman ,  Martin Ryan ,  Vladislav Davidkovich ,  Gordon Hill

发明人： David Goldman ,  Martin Ryan ,  Vladislav Davidkovich ,  Gordon Hill

IPC分类号： F16K31/12 ,  A01G25/16

CPC分类号： G05D16/2046 ,  Y10T137/86413

摘要： A master valve and at least one slave valve are connected via a network, wherein upon broadcast of a position setpoint of the master valve the at least one slave valve achieves a corresponding position within a shortened period of time, such network being a dedicated network or high speed shared network with position setpoint priority.

摘要翻译： 主阀和至少一个从阀通过网络连接，其中在广播主阀的位置设定点时，至少一个从阀在缩短的时间段内实现对应的位置，这样的网络是专用网络或 具有位置设定值优先级的高速共享网络。

公开(公告)号：US5965549A

公开(公告)日：1999-10-12

申请号：US801891

申请日：1997-02-18

申请人： Shivaji Purwar ,  David Goldman

发明人： Shivaji Purwar ,  David Goldman

IPC分类号： A61K9/00 ,  A61K9/10 ,  A61K31/57 ,  A61K47/00 ,  A61K47/32 ,  A61P27/16 ,  A61K31/56 ,  A61K31/495

CPC分类号： A61K9/0046 ,  A61K31/57 ,  A61K47/32 ,  A61K9/0014 ,  A61K9/10

摘要： The invention is directed to an aqueous non-ototoxic, topical, otic pharmaceutical composition of matter for treating a mammal consisting essentially of: ciprofloxacin or a pharmaceutically acceptable salt thereof in aqueous solution in an amount effective for antibacterial action; hydrocortisone or a pharmaceutically acceptable salt thereof in an amount effective as an anti-inflammatory agent; polyvinyl alcohol at least about 85% hydrolyzed in an amount effective to suspend the hydrocortisone in solution; water sufficient to produce an aqueous composition; benzyl alcohol in an amount effective for antibacterial action; lecithin in an amount effective for enhancing suspension of other constituents in the composition; and polysorbate ranging from polysorbate 20 to 80 in an amount effective for spreading the preparation on a hydrophobic skin surface to the site of infection or inflammation.

摘要翻译： 本发明涉及用于治疗哺乳动物的水性非耳毒性，局部，耳用药物组合物，其基本上由以下组成：基本上由环丙沙星或其药学上可接受的盐在水溶液中以有效抗菌作用的量; 氢化可的松或其药学上可接受的盐作为抗炎剂有效的量; 至少约85％的聚乙烯醇以有效悬浮氢化可的松溶液的量水解; 足以产生含水组合物的水; 苄醇有效量的抗菌作用; 卵磷脂的量可以有效地增强组合物中其他成分的悬浮液; 和聚山梨醇酯的范围从聚山梨酸酯20至80，其用量将制剂在疏水性皮肤表面上扩散至感染或炎症部位。