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公开(公告)号：US20100022870A1
公开(公告)日：2010-01-28
申请号：US12458761
申请日：2009-07-22
IPC分类号： A61B5/055
CPC分类号： A61B5/0263 , A61B5/02007 , A61B5/055 , G01R33/4812 , G01R33/543 , G01R33/5601 , G01R33/5635
摘要： A method is disclosed for implementing an imaging examination method. In at least one embodiment, the method includes creating an overview data record containing angiography data relating to a patient; simulating flow conditions in vessels of the patient; determining a strain on the vascular walls with the aid of the simulation; identifying vascular regions, in which the strain on the vascular wall exceeds a threshold value and implementing an imaging examination in at least one of the identified vascular regions.
摘要翻译： 公开了一种用于实现成像检查方法的方法。 在至少一个实施例中，该方法包括创建包含与患者相关的血管造影数据的概览数据记录; 模拟患者血管中的流动状况; 借助于模拟确定血管壁上的应变; 识别血管壁的血管区域，其中血管壁上的应变超过阈值，并且在至少一个所识别的血管区域中实施成像检查。
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22.发明授权公开(公告)号：US07315784B2
公开(公告)日：2008-01-01
申请号：US09784720
申请日：2001-02-15
申请人： Klaus Abraham-Fuchs , Arne Hengerer , Norbert Windhab , Kieran T. Gallahue , James P. O'Connell , Greg Gosch
发明人： Klaus Abraham-Fuchs , Arne Hengerer , Norbert Windhab , Kieran T. Gallahue , James P. O'Connell , Greg Gosch
摘要： In a method and a network for evaluating medical data in a clinical study, biochips containing patient samples with multiple biomolecular markers are tested in a number of point of care test devices respectively at point of care sites. Each test of each biochip sample produces a diagnostic result, which is entered into the electronic patient record for the patient who produced the sample. A follow-up examination is subsequently conducted for each patient, and the results of the follow-up examination are also entered into that patient's electronic patient record. The follow-up results indicate whether the diagnostic test result was a false positive, a false negative or correct. The follow-up data and the original diagnostic results from all point of care sites are electronically transmitted to a remote server, which has access to an expert system which uses the test results and the follow-up data to automatically devise a measurement protocol for a selected pathology.
摘要翻译： 在临床研究中用于评估医学数据的方法和网络中，分别在护理部位的许多点护理测试装置中测试含有具有多个生物分子标记的患者样品的生物芯片。 每个生物芯片样品的每个测试产生诊断结果，其被输入到生产样品的患者的电子病人记录中。 随后对每名患者进行随访检查，随访检查结果也纳入该患者的电子病历。 随访结果表明诊断检查结果是假阳性，假阴性或正确。 来自所有护理点的后续数据和原始诊断结果被电子传输到远程服务器，该远程服务器可以访问使用测试结果的专家系统和后续数据来自动设计测量协议 选择病理学。
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公开(公告)号：US20070067252A1
公开(公告)日：2007-03-22
申请号：US11214637
申请日：2005-08-30
IPC分类号： G06F17/30
CPC分类号： G06Q50/22 , G06F19/321 , G16H10/60
摘要： A system and computer software for archiving image and other data relating to medical research, having the capability to store images in digital imaging and communication in medicine (DICOM) format. The images are retrievable using pointers contained in a relational data base where the image data is associated with experiments and projects and the access to the DICOM data is controlled through a hierarchical system of access control related to the project organization and administration. The computer servers and mass storage are linked by a local area network and a wide area network, permitting collaboration by persons a geographically dispersed locations.
摘要翻译： 一种用于归档与医学研究相关的图像和其他数据的系统和计算机软件，具有将数字成像和医学通信（DICOM）格式存储的能力。 可以使用包含在关系数据库中的指针来检索图像，其中图像数据与实验和项目相关联，并且通过与项目组织和管理相关的访问控制的分级系统来控制对DICOM数据的访问。 计算机服务器和大容量存储由局域网和广域网连接，允许人员在地理上分散的位置进行协作。
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24.发明申请Method for determining suitability of various contrast agents for the imaging examination of the patient and uses of the ligand contained in a selected contrast agent 有权用于确定用于患者的成像检查的各种造影剂的适合性的方法以及所选择的造影剂中所含的配体的用途公开(公告)号：US20060133995A1
公开(公告)日：2006-06-22
申请号：US11305003
申请日：2005-12-19
申请人： Arne Hengerer
发明人： Arne Hengerer
IPC分类号： A61K51/00
CPC分类号： G01N33/58 , A61K49/0002
摘要： A method is for determining suitability of various contrast agents for the imaging examination of the. In this case, a tissue sample is taken from the patient, it is divided into a plurality of individual samples and a contrast agent which binds to a particular target structure in the tissue is added to each individual sample. The individual samples are examined by an analysis or imaging method in order to determine the suitability of the various contrast agents for the imaging examination of the patient.
摘要翻译： 一种方法是确定各种造影剂对于成像检查的适用性。 在这种情况下，从患者取出组织样本，将其分成多个单独的样品，并将与组织中的特定目标结构结合的造影剂加入每个单个样品中。 通过分析或成像方法检查各个样品，以确定各种造影剂对于患者的成像检查的适合性。
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公开(公告)号：US06833915B2
公开(公告)日：2004-12-21
申请号：US10188745
申请日：2002-07-05
IPC分类号： G01N2164
CPC分类号： A61B5/0059 , A61B6/508 , A61B2503/40
摘要： Optical diagnosis system for small animal imaging, in which the animal which has been arranged on a bearing plate and treated with an activatable optical contrast medium is irradiated by an excitation source and the resulting fluorescent radiation that is radiated back is detected by a detector system, in which case the bearing plate is designed as a radiation-transparent window (13) for a reference radiation—generated by a second marker of the contrast medium—for the detection of the initial concentration of the inert contrast medium.
摘要翻译： 用于小动物成像的光学诊断系统，其中已经布置在支承板上并用可激活的光学造影剂处理的动物被激发源照射，并且所产生的被辐射回的荧光辐射由检测器系统检测， 在这种情况下，承载板被设计为用于由造影剂的第二标记物产生的参考辐射的辐射透明窗口（13），用于检测惰性造影剂的初始浓度。
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公开(公告)号：US10353026B2
公开(公告)日：2019-07-16
申请号：US15183201
申请日：2016-06-15
IPC分类号： G01V3/00 , G01R33/3415 , G01R33/34 , G01R33/36
摘要： In order to provide interventional access during an image-guided interventional procedure, while increasing the signal-to-noise ratio for generated images compared to a single loop coil, a local coil includes a single coil element disposed around an opening through the local coil and two coil elements positioned on opposite sides of the single coil element. The opening provides access for an interventional tool used during the image-guided interventional procedure.
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公开(公告)号：US09739856B2
公开(公告)日：2017-08-22
申请号：US13922568
申请日：2013-06-20
申请人： Randy Buckner , Bjoern Heismann , Arne Hengerer
发明人： Randy Buckner , Bjoern Heismann , Arne Hengerer
CPC分类号： G01R33/4806
摘要： In a method and apparatus for acquiring magnetic resonance data, a resting state functional magnetic resonance imaging sequence is executed in alternation with a morphological data acquisition sequence. The alternating sequences are executed with no time interruptions therebetween, with at least one repetition of the alternating sequences. The resting state functional magnetic resonance imaging sequence can be a BOLD-EPI sequence, and the morphological imaging sequence can be an MPRAGE sequence.
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28.发明授权Combined MR-optical coil for prostate, cervix and rectum cancer imaging diagnostics 有权用于前列腺，子宫颈和直肠癌成像诊断的组合MR光学线圈公开(公告)号：US07894876B2
公开(公告)日：2011-02-22
申请号：US11048312
申请日：2005-02-01
IPC分类号： A61B5/05
CPC分类号： G01R33/285 , G01R33/24 , G01R33/34084
摘要： We present, in exemplary embodiments of the present invention, a system combining anatomical imaging technologies (e.g., MR) with optical technologies. The system can be used for a variety of applications, including, but not limited to, (1) cancer diagnosis and staging; (2) image guidance; and (3) radiation therapy planning. Image guidance may include guiding a biopsy. For example, a prostatectomy potentially has severe side effects, such as impotence and incontinence. Thus, a histologically-confirmed diagnosis, such as one provided from a biopsy, may prevent unnecessary prostatectomy. Image guidance may also include guiding minimal invasive therapy, such as brachytherapy focused ultrasound. The present invention may be used to plan radiation therapy, for example, by detecting, and thus sparing, healthy tissue from radiation exposure.
摘要翻译： 在本发明的示例性实施例中，存在将解剖成像技术（例如，MR）与光学技术相结合的系统。 该系统可用于各种应用，包括但不限于（1）癌症诊断和分期; （2）图像指导; 和（3）放射治疗计划。 图像指导可能包括指导活检。 例如，前列腺切除术可能具有严重的副作用，例如阳ence和失禁。 因此，组织学确诊的诊断，例如从活组织检查提供的诊断可以防止不必要的前列腺切除术。 图像引导还可以包括引导最小侵入性治疗，例如近距离放射治疗聚焦超声。 本发明可以用于计划放射治疗，例如通过从辐射暴露中检测健康组织并因此节省健康组织。
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29.发明授权Method for determining suitability of various contrast agents for the imaging examination of the patient and uses of the ligand contained in a selected contrast agent 有权用于确定用于患者的成像检查的各种造影剂的适合性的方法以及所选择的造影剂中所含的配体的用途公开(公告)号：US07713516B2
公开(公告)日：2010-05-11
申请号：US11305003
申请日：2005-12-19
申请人： Arne Hengerer
发明人： Arne Hengerer
CPC分类号： G01N33/58 , A61K49/0002
摘要： A method is for determining suitability of various contrast agents for the imaging examination of the. In this case, a tissue sample is taken from the patient, it is divided into a plurality of individual samples and a contrast agent which binds to a particular target structure in the tissue is added to each individual sample. The individual samples are examined by an analysis or imaging method in order to determine the suitability of the various contrast agents for the imaging examination of the patient.
摘要翻译： 一种方法是确定各种造影剂对于成像检查的适用性。 在这种情况下，从患者取出组织样本，将其分成多个单独的样品，并将与组织中的特定目标结构结合的造影剂加入每个单个样品中。 通过分析或成像方法检查各个样品，以确定各种造影剂对于患者的成像检查的适合性。
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公开(公告)号：US20090196866A1
公开(公告)日：2009-08-06
申请号：US12230770
申请日：2008-09-04
申请人： Arne Hengerer
发明人： Arne Hengerer
CPC分类号： A61K45/06 , A61K31/00 , A61K47/64 , A61K47/6923 , B82Y5/00 , A61K2300/00
摘要： A pharmaceutical composition is disclosed. In at least one embodiment, a pharmaceutical drug is linked via a peptide linker to an iron-binding agent, for example an iron-binding protein, with the iron-binding agent in turn being bound to an iron-containing magnetic particle. The peptide linker has a protease recognition sequence, i.e. it may be cleaved at said protease recognition sequence by a protease, thereby enabling the pharmaceutical drug to be released locally. The pharmaceutical composition is suitable for magnetic drug targeting.
摘要翻译： 公开了药物组合物。 在至少一个实施方案中，药物通过肽接头连接到铁结合剂，例如铁结合蛋白，铁结合剂又结合于含铁磁性颗粒。 肽接头具有蛋白酶识别序列，即其可以通过蛋白酶在所述蛋白酶识别序列处被切割，从而使得药物可以局部释放。 药物组合物适用于磁性药物靶向。
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