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公开(公告)号：US20100069348A1
公开(公告)日：2010-03-18
申请号：US12560893
申请日：2009-09-16
申请人： William A. Carroll , Michael J. Dart , Jennifer M. Frost , Steven P. Latshaw , Teodozyj Kolasa , Tongmei Li , Sridhar Peddi , Bo Liu , Arturo Perez-Medrano , Meena Patel , Xueqing Wang , Derek W. Nelson
发明人： William A. Carroll , Michael J. Dart , Jennifer M. Frost , Steven P. Latshaw , Teodozyj Kolasa , Tongmei Li , Sridhar Peddi , Bo Liu , Arturo Perez-Medrano , Meena Patel , Xueqing Wang , Derek W. Nelson
IPC分类号： A61K31/397 , C07D405/02 , A61K31/4155 , A61P29/00 , A61P35/00 , A61P37/00 , A61P25/00 , A61P3/04 , A61P11/00 , A61P3/10 , A61P9/00 , C07D417/02 , A61K31/454
CPC分类号： C07D405/12 , C07D231/40 , C07D285/135 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12
摘要： Disclosed herein are cannabinoid receptor ligands of formula (I) wherein A1, A5, Rx, X4, and z are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
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公开(公告)号：US20080242654A1
公开(公告)日：2008-10-02
申请号：US12051538
申请日：2008-03-19
申请人： Teodozyj Kolasa , Jennifer M. Frost , Meena V. Patel , Steven P. Latshaw , Arturo Perez-Medrano , Xueqing Wang , Sridhar Peddi , William A. Carroll , Michael J. Dart
发明人： Teodozyj Kolasa , Jennifer M. Frost , Meena V. Patel , Steven P. Latshaw , Arturo Perez-Medrano , Xueqing Wang , Sridhar Peddi , William A. Carroll , Michael J. Dart
IPC分类号： C07D277/18 , A61K31/426 , A61K31/397 , A61K31/4436 , C07D417/02 , A61K31/5377 , A61K31/4535 , A61P11/00 , A61P9/00 , A61P25/00 , A61P35/00 , A61P37/00
CPC分类号： C07D277/46 , C07D417/06 , C07D417/12 , C07D513/04 , Y02P20/582
摘要： The present application relates to thiazolylidene containing compounds of formula (I) wherein R1, R2, R3, R4, L2 and A are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
摘要翻译： 本申请涉及式（I）的含噻唑基的化合物，其中R 1，R 2，R 3，R 4， / SUB>，L 2＆gt;和A如说明书中所定义。 还公开了包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。
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23.发明授权Fused bicyclic aromatic compounds that are useful in treating sexual dysfunction 有权用于治疗性功能障碍的稠合双环芳香化合物公开(公告)号：US07057042B2
公开(公告)日：2006-06-06
申请号：US10443814
申请日：2003-05-23
IPC分类号： C07D491/04 , C07D495/04 , C07D498/04 , C07D513/04
CPC分类号： A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/495 , A61K31/496 , C07D471/04 , C07D491/04 , C07D495/04 , C07D513/04
摘要： The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction, wherein A, L, D and B1 are as described in the specification.
摘要翻译： 本发明涉及式（I）化合物用于治疗性功能障碍的用途和含有式（I）化合物用于治疗性功能障碍的组合物的用途，其中A，L，D和B < / SUB>如说明书中所述。
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公开(公告)号：US08859596B2
公开(公告)日：2014-10-14
申请号：US12560893
申请日：2009-09-16
申请人： William A. Carroll , Michael J. Dart , Jennifer M. Frost , Steven P. Latshaw , Teodozyj Kolasa , Tongmei Li , Sridhar Peddi , Bo Liu , Arturo Perez-Medrano , Meena Patel , Xueqing Wang , Derek W. Nelson
发明人： William A. Carroll , Michael J. Dart , Jennifer M. Frost , Steven P. Latshaw , Teodozyj Kolasa , Tongmei Li , Sridhar Peddi , Bo Liu , Arturo Perez-Medrano , Meena Patel , Xueqing Wang , Derek W. Nelson
IPC分类号： A61K31/433 , C07D285/12 , C07D405/12 , C07D413/14 , C07D413/12 , C07D403/12 , C07D405/14 , C07D409/14 , C07D417/12 , C07D285/135 , C07D231/40
CPC分类号： C07D405/12 , C07D231/40 , C07D285/135 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12
摘要： Disclosed herein are cannabinoid receptor ligands of formula (I) wherein A1, A5, Rx, X4, and z are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
摘要翻译： 本文公开了式（I）的大麻素受体配体，其中A1，A5，Rx，X4和z如说明书中所定义。 还公开了包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。
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公开(公告)号：US08492371B2
公开(公告)日：2013-07-23
申请号：US12732421
申请日：2010-03-26
申请人： William A. Carroll , Michael J. Dart , Jennifer M. Frost , Steven P. Latshaw , Tongmei Li , Bo Liu , Sridhar Peddi , Xueqing Wang , Teodozyj Kolasa , Derek W. Nelson , Arturo Perez-Medrano
发明人： William A. Carroll , Michael J. Dart , Jennifer M. Frost , Steven P. Latshaw , Tongmei Li , Bo Liu , Sridhar Peddi , Xueqing Wang , Teodozyj Kolasa , Derek W. Nelson , Arturo Perez-Medrano
IPC分类号： A61K31/397 , A61K31/433 , A61K31/42 , A61K31/416 , A61K31/4155 , A61K31/422 , C07D205/02 , C07D285/12 , C07D261/02 , C07D231/10 , C07D231/54 , C07D263/02
CPC分类号： C07D417/06 , C07D405/06 , C07D413/06
摘要： Disclosed herein are compounds of formula (I) wherein Ring A and R1 are as defined in the specification. Pharmaceutical compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and pharmaceutical compositions are also disclosed.
摘要翻译： 本文公开了式（I）的化合物，其中环A和R 1如说明书中所定义。 还公开了包含这些化合物的药物组合物，以及使用这些化合物和药物组合物治疗病症和障碍的方法。
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公开(公告)号：US08188135B2
公开(公告)日：2012-05-29
申请号：US12560897
申请日：2009-09-16
申请人： William A. Carroll , Michael J. Dart , Jennifer M. Frost , Steven P. Latshaw , Teodozyj Kolasa , Tongmei Li , Sridhar Peddi , Bo Liu , Arturo Perez-Medrano , Meena Patel , Xueqing Wang , Derek W. Nelson
发明人： William A. Carroll , Michael J. Dart , Jennifer M. Frost , Steven P. Latshaw , Teodozyj Kolasa , Tongmei Li , Sridhar Peddi , Bo Liu , Arturo Perez-Medrano , Meena Patel , Xueqing Wang , Derek W. Nelson
IPC分类号： A61K31/415 , C07D231/06
CPC分类号： C07D405/12 , C07D231/40 , C07D285/135 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12
摘要： Disclosed herein are cannabinoid receptor ligands of formula (I) wherein A1, A5, Rx, X4, and z are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
摘要翻译： 本文公开了式（I）的大麻素受体配体，其中A1，A5，Rx，X4和z如说明书中所定义。 还公开了包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。
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公开(公告)号：US07985768B2
公开(公告)日：2011-07-26
申请号：US11848512
申请日：2007-08-31
申请人： Derek W. Nelson , Steven P. Latshaw
发明人： Derek W. Nelson , Steven P. Latshaw
IPC分类号： A61K31/381 , C07D495/04
CPC分类号： C07D495/04
摘要： The present invention relates to thiophene containing compounds of formula (I) wherein R1, R2, R3, and n are as defined in the specification, pharmaceutical compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and pharmaceutical compositions.
摘要翻译： 本发明涉及含噻吩的式（I）化合物，其中R 1，R 2，R 3和n如说明书中所定义，包含这些化合物的药物组合物，以及使用这些化合物和药物组合物治疗病症和病症的方法。
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公开(公告)号：US07875640B2
公开(公告)日：2011-01-25
申请号：US12051538
申请日：2008-03-19
申请人： Teodozyj Kolasa , Jennifer M. Frost , Meena V. Patel , Steven P. Latshaw , Arturo Perez-Medrano , Xueqing Wang , Sridhar Peddi , William A. Carroll , Michael J. Dart
发明人： Teodozyj Kolasa , Jennifer M. Frost , Meena V. Patel , Steven P. Latshaw , Arturo Perez-Medrano , Xueqing Wang , Sridhar Peddi , William A. Carroll , Michael J. Dart
IPC分类号： A61K31/426 , C07D277/08
CPC分类号： C07D277/46 , C07D417/06 , C07D417/12 , C07D513/04 , Y02P20/582
摘要： The present application relates to thiazolylidene containing compounds of formula (I) wherein R1, R2, R3, R4, L2 and A are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
摘要翻译： 本申请涉及含有噻唑类的式（I）化合物，其中R 1，R 2，R 3，R 4，L 2和A如说明书中所定义。 还公开了包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。
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公开(公告)号：US20100249129A1
公开(公告)日：2010-09-30
申请号：US12732421
申请日：2010-03-26
申请人： William A. Carroll , Michael J. Dart , Jennifer M. Frost , Steven P. Latshaw , Tongmei Li , Bo Liu , Sridhar Peddi , Xueqing Wang , Teodozyj Kolasa , Derek W. Nelson , Arturo Perez-Medrano
发明人： William A. Carroll , Michael J. Dart , Jennifer M. Frost , Steven P. Latshaw , Tongmei Li , Bo Liu , Sridhar Peddi , Xueqing Wang , Teodozyj Kolasa , Derek W. Nelson , Arturo Perez-Medrano
IPC分类号： A61K31/433 , C07D417/08 , C07D417/06 , C07D405/06 , A61K31/443 , C07D413/06 , A61K31/422 , A61K31/4025 , A61K31/403 , C07D405/14 , C07D413/14 , A61K31/5377 , A61P29/00 , A61P25/00 , A61P37/02 , A61P11/00 , A61P35/00 , A61P9/00
CPC分类号： C07D417/06 , C07D405/06 , C07D413/06
摘要： Disclosed herein are compounds of formula (I) wherein Ring A and R1 are as defined in the specification. Pharmaceutical compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and pharmaceutical compositions are also disclosed.
摘要翻译： 本文公开了式（I）的化合物，其中环A和R 1如说明书中所定义。 还公开了包含这些化合物的药物组合物，以及使用这些化合物和药物组合物治疗病症和障碍的方法。
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公开(公告)号：US20100216760A1
公开(公告)日：2010-08-26
申请号：US12639173
申请日：2009-12-16
申请人： Jennifer M. Frost , Steven P. Latshaw , Michael J. Dart , William A. Carroll , Arturo Perez-Medrano , Teodozyj Kolasa , Meena V. Patel , Derek W. Nelson , Tongmei Li , Sridhar Peddi , Xueqing Wang , Bo Liu
发明人： Jennifer M. Frost , Steven P. Latshaw , Michael J. Dart , William A. Carroll , Arturo Perez-Medrano , Teodozyj Kolasa , Meena V. Patel , Derek W. Nelson , Tongmei Li , Sridhar Peddi , Xueqing Wang , Bo Liu
IPC分类号： A61K31/427 , C07D417/12 , C07D471/04 , A61K31/437 , A61P29/00
CPC分类号： C07D417/12 , C07D277/46 , C07D513/04
摘要： Disclosed herein are cannabinoid receptor ligands of formula (I) wherein L1, A1, R1g, z, R2, R3, and R4 are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.
摘要翻译： 本文公开了式（I）的大麻素受体配体，其中L1，A1，R1g，z，R2，R3和R4如说明书中所定义。 还提出了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和障碍的方法。
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