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1.发明授权Fused bicyclic aromatic compounds that are useful in treating sexual dysfunction 有权用于治疗性功能障碍的稠合双环芳香化合物公开(公告)号：US07235661B2
公开(公告)日：2007-06-26
申请号：US11395807
申请日：2006-03-31
IPC分类号： C07D495/04 , C07D513/04 , A61K31/496 , A61K31/506
CPC分类号： A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/495 , A61K31/496 , C07D471/04 , C07D491/04 , C07D495/04 , C07D513/04
摘要： The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction, wherein A, L, D and B1, are as described in the specification.
摘要翻译： 本发明涉及式（I）化合物用于治疗性功能障碍的用途和含有式（I）化合物用于治疗性功能障碍的组合物的用途，其中A，L，D和B < / SUB>，如说明书中所述。
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2.发明授权Fused bicyclic aromatic compounds that are useful in treating sexual dysfunction 有权用于治疗性功能障碍的稠合双环芳香化合物公开(公告)号：US07057042B2
公开(公告)日：2006-06-06
申请号：US10443814
申请日：2003-05-23
IPC分类号： C07D491/04 , C07D495/04 , C07D498/04 , C07D513/04
CPC分类号： A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/495 , A61K31/496 , C07D471/04 , C07D491/04 , C07D495/04 , C07D513/04
摘要： The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction, wherein A, L, D and B1 are as described in the specification.
摘要翻译： 本发明涉及式（I）化合物用于治疗性功能障碍的用途和含有式（I）化合物用于治疗性功能障碍的组合物的用途，其中A，L，D和B < / SUB>如说明书中所述。
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3.发明授权Fused bicyclic aromatic compounds that are useful in treating sexual dysfunction 有权用于治疗性功能障碍的稠合双环芳香化合物公开(公告)号：US07470691B2
公开(公告)日：2008-12-30
申请号：US11747955
申请日：2007-05-14
IPC分类号： A61K31/496 , A61K31/506
CPC分类号： A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/495 , A61K31/496 , C07D471/04 , C07D491/04 , C07D495/04 , C07D513/04
摘要： The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction, wherein A, L, D and B1 are as described in the specification.
摘要翻译： 本发明涉及式（I）化合物用于治疗性功能障碍的用途，以及含有式（I）化合物用于治疗性功能障碍的组合物的用途，其中A，L，D和B1如 规范。
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公开(公告)号：US07022728B2
公开(公告)日：2006-04-04
申请号：US10094265
申请日：2002-03-08
申请人： Marlon D. Cowart , Pramila A. Bhatia , Jerome F. Daanen , Andrew O. Stewart , Meena V. Patel , Teodozyj Kolasa , Jorge D. Brioni , Jeffrey Rohde
发明人： Marlon D. Cowart , Pramila A. Bhatia , Jerome F. Daanen , Andrew O. Stewart , Meena V. Patel , Teodozyj Kolasa , Jorge D. Brioni , Jeffrey Rohde
IPC分类号： A61K31/415 , A61K31/495 , A61K31/50
CPC分类号： A61K31/496
摘要： The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.
摘要翻译： 本发明涉及式（I）化合物用于治疗性功能障碍的用途，以及含有式（I）化合物用于治疗性功能障碍的组合物的用途。
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公开(公告)号：US06960589B2
公开(公告)日：2005-11-01
申请号：US10236812
申请日：2002-09-06
申请人： Marlon D. Cowart , Pramila A. Bhatia , Jerome F. Daanen , Andrew O. Stewart , Meena V. Patel , Teodozyj Kolasa , Jorge D. Brioni , Jeffrey Rohde , Kenneth M. Engstrom
发明人： Marlon D. Cowart , Pramila A. Bhatia , Jerome F. Daanen , Andrew O. Stewart , Meena V. Patel , Teodozyj Kolasa , Jorge D. Brioni , Jeffrey Rohde , Kenneth M. Engstrom
IPC分类号： A61K31/496 , C07D401/12 , C07D403/12 , A61P15/00
CPC分类号： C07D401/12 , A61K31/496 , C07D403/12
摘要： The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction, wherein L is C1-4 alkyl; RA, RB, RC, RD, and RE, are as described in the specification; Z is selected from the group consisting of N, C and CH; and A is aryl and heteroaryl as described in the specification.
摘要翻译： 本发明涉及式（I）化合物用于治疗性功能障碍的用途，以及含有式（I）化合物用于治疗性功能障碍的组合物的用途，其中L为C 1-4 烷基; R A，R B，R C，R D和R E， ，如说明书所述; Z选自N，C和CH; 并且A是如说明书中所述的芳基和杂芳基。
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公开(公告)号：US07351828B2
公开(公告)日：2008-04-01
申请号：US10699465
申请日：2003-10-31
申请人： Marlon D. Cowart , Pramila A. Bhatia , Jerome F. Daanen , Andrew O. Stewart , Meena V. Patel , Teodozyj Kolasa , Jorge D. Brioni , Jeffrey Rohde
发明人： Marlon D. Cowart , Pramila A. Bhatia , Jerome F. Daanen , Andrew O. Stewart , Meena V. Patel , Teodozyj Kolasa , Jorge D. Brioni , Jeffrey Rohde
IPC分类号： C07D401/04 , C07D403/04
CPC分类号： A61K31/496
摘要： The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.
摘要翻译： 本发明涉及式（I）化合物用于治疗性功能障碍的用途，以及含有式（I）化合物用于治疗性功能障碍的组合物的用途。
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公开(公告)号：US08546410B2
公开(公告)日：2013-10-01
申请号：US12435876
申请日：2009-05-05
IPC分类号： A61K31/505 , A01N43/54 , C07D487/00 , C07D491/00
CPC分类号： C07D498/04 , C07D495/04
摘要： Heteroaryl-fused macrocyclic 2,4-diaminopyrimidine compounds of formula (I) wherein W, G1, G2, A1 and R1 are defined in the description, compositions comprising such compounds, methods for making the compounds, and methods of treating and preventing the progression of diseases, conditions, and disorders using such compounds and compositions are described herein.
摘要翻译： 其中W，G1，G2，A1和R1在说明书中定义的式（I）的杂芳基稠合的大环2,4-二氨基嘧啶化合物，包含这些化合物的组合物，制备该化合物的方法，以及治疗和预防进展的方法 使用这些化合物和组合物的疾病，病症和病症在本文中描述。
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公开(公告)号：US20130040940A1
公开(公告)日：2013-02-14
申请号：US13571070
申请日：2012-08-09
申请人： Marlon D. Cowart , Huaqing Liu , Robert Altenbach
发明人： Marlon D. Cowart , Huaqing Liu , Robert Altenbach
IPC分类号： A61K31/551 , A61P9/10 , A61P25/28 , A61P11/06 , A61P25/00 , A61P35/00 , A61P25/30 , A61P3/10 , A61P25/24 , A61P25/08 , A61P1/00 , A61P29/00 , A61P3/00 , A61P25/06 , A61P3/04 , A61P25/16 , A61P25/18 , A61P25/20 , C07D513/04
CPC分类号： C07D513/04
摘要： Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions of compounds of formula (I), methods for using such compounds and compositions, and a process for preparing the compounds.
摘要翻译： 式（I）化合物可用于治疗由组胺-3受体配体预防或改善的病症或病症。 还公开了式（I）化合物的药物组合物，使用这些化合物和组合物的方法及其制备方法。
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公开(公告)号：US08273767B2
公开(公告)日：2012-09-25
申请号：US12849697
申请日：2010-08-03
申请人： Robert J. Altenbach , Lawrence A. Black , Sou-Jen Chang , Marlon D. Cowart , Ramin Faghih , Gregory A. Gfesser , Yi-Yin Ku , Huaqing Liu , Kirill A. Lukin , Diana L. Nersesian , Yu-ming Pu , Padam N. Sharma , Youssef L. Bennani , Michael P. Curtis
发明人： Robert J. Altenbach , Lawrence A. Black , Sou-Jen Chang , Marlon D. Cowart , Ramin Faghih , Gregory A. Gfesser , Yi-Yin Ku , Huaqing Liu , Kirill A. Lukin , Diana L. Nersesian , Yu-ming Pu , Padam N. Sharma , Youssef L. Bennani , Michael P. Curtis
IPC分类号： C07D413/02 , C07D417/02 , A61K31/4439 , A61K31/506
CPC分类号： C07D207/14 , C07D207/08 , C07D207/12 , C07D207/20 , C07D213/30 , C07D213/38 , C07D213/61 , C07D213/64 , C07D213/85 , C07D215/12 , C07D215/14 , C07D215/20 , C07D217/14 , C07D237/12 , C07D237/14 , C07D237/28 , C07D239/26 , C07D239/28 , C07D239/42 , C07D239/52 , C07D241/12 , C07D241/42 , C07D263/32 , C07D277/28 , C07D295/073 , C07D295/088 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/155 , C07D401/04 , C07D401/10 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D471/04
摘要： Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
摘要翻译： 式（I）化合物可用于治疗由组胺-3受体配体预防或改善的病症或病症。 还公开了包含组胺-3受体配体的药物组合物，使用这些化合物和组合物的方法，以及制备式（I）范围内的化合物的方法。
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公开(公告)号：US07807697B2
公开(公告)日：2010-10-05
申请号：US12022041
申请日：2008-01-29
申请人： Marlon D. Cowart , Yi-Yin Ku , Sou-Jen Chang , Dilinie P. Fernando , Timothy A. Grieme , Robert J. Altenbach
发明人： Marlon D. Cowart , Yi-Yin Ku , Sou-Jen Chang , Dilinie P. Fernando , Timothy A. Grieme , Robert J. Altenbach
IPC分类号： A61K31/4184 , A61K31/4439 , A61K31/4025 , C07D401/02 , C07D401/14 , C07D235/02 , C07D207/04
CPC分类号： C07D263/56 , C07D209/14 , C07D235/14 , C07D277/28 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D413/06 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/14
摘要： Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands and methods for using such compounds and compositions.
摘要翻译： 式（I）化合物可用于治疗由组胺-3受体配体预防或改善的病症或病症。 还公开了包含组胺-3受体配体的药物组合物和使用这些化合物和组合物的方法。
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