摘要:
The present invention relates to nanocapsules, including: a core essentially consisting of a fatty substance, which is liquid or semi-liquid at ambient temperature, and including a hydrophobic active principle and a diethylene glycol ether; an outer lipid shell which is solid at ambient temperature. The lipid nanocapsules of the invention are intended in particular for the manufacture of a drug.
摘要:
A single-dose solid composition useful for cleaning or treating human or animal hair and having a high disintegration rate in water is disclosed. The composition includes at least one surface active agent selected from the group consisting of an anionic surface active agent and a nonionic surface active agent, an amphoteric product and at least one disintegrating agent. The composition has a disintegration time in an aqueous medium selected from the group consisting of water and aqueous solutions of less than about 5 minutes. The disintegrating agent consists essentially of polyvinylpyrrolidone. A method for making said composition is also disclosed.
摘要:
A chain connector for holding a chain (14) that moors a vessel to the sea floor under perhaps 2000 tons tension, which can be quickly disconnected in an emergency by applying a moderate disconnecting force such as 50 tons. The chain is hold by ratchets (24, 26) that are mounted on arms (34, 36). The arms have upper ends (35) that am pivotally mounted on a housing (38) and have free lower ends (44), with the lower ends being held by cams (50) on locking dogs (52) that have locking dog lower ends (51) pivotally mounted on the housing and free upper ends (60). A hydraulic actuator (70) has pins (58) that engage the upper ends of the locking dogs to prevent the arms and dogs from pivoting apart until the looking dog upper ends (60) are raised.
摘要:
A chain connector for holding a chain (14) that moors a vessel to the sea floor under perhaps 2000 tons tension, which can be quickly disconnected in an emergency by applying a moderate disconnecting force such as 50 tons. The chain is hold by ratchets (24, 26) that are mounted on arms (34, 36). The arms have upper ends (35) that am pivotally mounted on a housing (38) and have free lower ends (44), with the lower ends being held by cams (50) on locking dogs (52) that have locking dog lower ends (51) pivotally mounted on the housing and free upper ends (60). A hydraulic actuator (70) has pins (58) that engage the upper ends of the locking dogs to prevent the arms and dogs from pivoting apart until the looking dog upper ends (60) are raised.
摘要:
The present invention relates to a method for preparing poloxamer-protein particles. It also relates to poloxamer-protein particles obtainable by this method, dispersion thereof, and their use in methods of encapsulation, in particular of microencapsulation.
摘要:
The present invention relates to a method for preparing particles, notably particles encapsulating an active substance. It also relates to particles obtainable by this process, dispersion thereof, and their use as a vehicle for pharmaceutical, cosmetic, diagnostic, veterinary, phytosanitary active substances or processed foodstuff.
摘要:
The invention relates to the use of biodegradable microspheres that release a radiosensitizing anticancer agent for producing a medicament to be used simultaneously with, separately from or spread over time with a radiotherapy, for treating glioblastoma. The use of said biodegradable microspheres according to the invention results in a patient survival time of at least 90 weeks, a therapeutically effective concentration being maintained in the parenchymatous area throughout this time. The microspheres used preferably contain 5-fluorouracile of the tumor, by intratissular injection. The radiotherapy targeting the tumorous mass is dosed at 60 Gy over approximately 6 weeks. The invention also relates to a method for producing the biodegradable microspheres by emulsion-extraction, and to a suspension containing the biodegradable microspheres obtained using this method.
摘要:
Use of a colloidal carrier for the manufacture of a medicament for inhibiting P-glycoprotein, wherein said colloidal carrier:—encapsulates or adsorbs a pharmacologically active substance, and—comprises P-glycoprotein inhibitor surfactants bound to the colloidal carrier surface.
摘要:
Microparticles including a biodegradable, biocompatible material having at least a portion of surface adapted to adhere to cells of interest or fragments thereof; and at least one substance active on the cells or their environment upon implantation of the microparticles in a patient associated with the material wherein the substances is released in a controlled and/or extended manner.
摘要:
The invention relates to the use of biodegradable microspheres that release a radiosensitizing anticancer agent for producing a medicament to be used simultaneously with, separately from or spread over time with a radiotherapy, for treating glioblastoma. The use of said biodegradable microspheres according to the invention results in a patient survival time of least 90 weeks, a thereapeutically effective concentration being maintained in the parenchymatous area throughout this time. The microspheres used prefereably contain 5-fluorouracile of the tumor, by intratissular injection. The radiothereapy targeting the tumorous mass is dosed at 60 Gy over approximately 6 weeks. The invention also relates to a method for producing the biodegradable microspheres by emulsion-extraction, and to a suspension containing the biodegradable microspheres obtained using this method.